DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	524	Identity:	153/524 - (29%)
Similarity:	242/524 - (46%)	Gaps:	79/524 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLRLGPQ----LW 76
            |...|  |.:||....||...|||.|..:......:|:..:....       |||..||    .|
Mouse     4 LCLSW--LGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCS-------RLRCFPQPPKPSW 59

  Fly    77 VFLHSA-----EETRQAL-------HD----------PTLR--------------------KADT 99
            .:.|.|     ||:.|.:       ||          |.||                    :...
Mouse    60 FWGHLALMKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTL 124

  Fly   100 FMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVE------RLVGRLGATRG 158
            :..|:|.:|:|||:|.|..|:..||||||||...:|:|:.......|.      :.:...|.:|
Mouse   125 YGFLKPWLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSR- 188

  Fly   159 AFLEVTEPLFACLLDAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRT 223
              |::.|.:....||::.........:.|..|...|.....||| |:.||...|.|..|.::..|
Mouse   189 --LDMFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSS-LVVKRHRQPFLYLDLLYYLT 250

  Fly   224 QLWRDLDEQLQVIHSQMESVIEKRAKELLDMG------EPAGRAHNLLDTLLLAKFE-GQSLSRR 281
            ...|...:...::|:..::||::|...|...|      :...:..:.:|.||:|:.| |:.||..
Mouse   251 ADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLDFIDVLLMAEDEHGKGLSNE 315

  Fly   282 EIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD---ETTDLDALNGLPYL 343
            :||.|.:||:|.|.||||:|:|::||.||:.||.|.|.|:|:|::..|   |..:.|.|..||:|
Mouse   316 DIRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEWDDLAQLPFL 380

  Fly   344 EALIKEVLRLYTIVPTTGRQTTQSTEI-GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWL 407
            ...|||.|||:..|....|..||...: .||....|....|:::|:.|:...:|||..:.|.|:.
Mouse   381 TMCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVWPDPEVYNPFRFD 445

  Fly   408 PEDGAVAPPAFSYIPFSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKA 472
            ||:.....| .::||||.|...|||:.:::..:|:..|..:..|:  :.|:....|.:.:::|:|
Mouse   446 PENPQKRSP-LAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFR--ILPDDKEPRRKPELILRA 507

  Fly   473 QQGI 476
            :.|:
Mouse   508 EGGL 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	148/510 (29%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	138/467 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810