Protein Alignment Cyp311a1 and CYP51A1

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_000777.1
• Gene: CYP51A1 / 1595
• HGNCID: 2649
• Length: 509
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 113/537 - (21%)
• Similarity: 198/537 - (36%)
• Gaps: 172/537 - (32%)

  Fly     3 LWPLLLI----TLTIWILVRKWTLLRLGS--SLPG-----PWAF---PLLGNAQMVGKLRPEYIF 53
            |..:|||    ||::..|:|    |..|.  .||.     |:.|   |.||:|...||...|::.
Human    32 LLSMLLIACAFTLSLVYLIR----LAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLE 92

  Fly    54 LVFTELRDRF-----GATYRLRLGPQLWVFLH-------SAEETRQALHDPTLRKA-------DT 99
            ..:.:....|     |.|:...||......|.       :||:....|..|...|.       ..
Human    93 NAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPV 157

  Fly   100 FMQLEPLIGNGLLISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLGATRGAFLEVT 164
            |::.:.::.:||.|:|    .:|...:......:...|:            |..|         .
Human   158 FLEQKKMLKSGLNIAH----FKQHVSIIEKETKEYFESW------------GESG---------E 197

  Fly   165 EPLFACLLDAIVDTSM----GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQL 225
            :.:|..|.:.|:.|:.    |.::.:|            |:.|:                  .||
Human   198 KNVFEALSELIILTASHCLHGKEIRSQ------------LNEKV------------------AQL 232

  Fly   226 WRDLD-------------------EQLQVIHSQMESV----IEKR--AKELLDMGEPAGRAHNLL 265
            :.|||                   .:....|.:::.:    |:||  ::|.:|         ::|
Human   233 YADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID---------DIL 288

  Fly   266 DTLLLAKF-EGQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYALAKFPETQTRLRKELQDVALD 329
            .|||.|.: :|:.|:..|:...:...:.||..|::...:::.:.||:....|.:...|.:.|..:
Human   289 QTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGE 353

  Fly   330 ETTDL--DALNGLPYLEALIKEVLRL-------------------YTIVPTTGRQTTQSTEIGGR 373
            ....|  |.|..|..|:..|||.|||                   |||.|  |.|...|..:..|
Human   354 NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPP--GHQVCVSPTVNQR 416

  Fly   374 TYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRYSLL 438
            .                 |:.:.:...|.|:|:| :|...:...|:|:||..|.|.|||..::.:
Human   417 L-----------------KDSWVERLDFNPDRYL-QDNPASGEKFAYVPFGAGRHRCIGENFAYV 463

  Fly   439 LMKLLTARLVREFQMEL 455
            .:|.:.:.::|.::.:|
Human   464 QIKTIWSTMLRLYEFDL 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	91/457 (20%)
CYP51A1	NP_000777.1	CYP51-like	94..505	CDD:410668	92/471 (20%)