Protein Alignment Cyp311a1 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 158/501 - (31%)
• Similarity: 253/501 - (50%)
• Gaps: 53/501 - (10%)

  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR--DRFGATYR 68
            ||||......|.|:| ||:.....|.|.:..|.|:.|   :|:.:      .||:  .::..|:.
Human    29 LLLIKAVQLYLHRQW-LLKALQQFPCPPSHWLFGHIQ---ELQQD------QELQRIQKWVETFP 83

  Fly    69 LRLGPQLWVFLHSAEETRQALHDPTLRKA----------DTFMQLEPLIGNGLLISHGAHWTRQR 123
            ......||     ..:.|..|:||...|.          .::..|.|.||.|||:.:|..|.:.|
Human    84 SACPHWLW-----GGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHR 143

  Fly   124 RLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLDAIVDTSMG 181
            |:|||||...:|:.:...:...|       |.|:|     :.:.|||.:.:....||.|:..:..
Human   144 RMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLG-----QDSPLEVFQHVSLMTLDTIMKCAFS 203

  Fly   182 AQLDTQSVDHS--PIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVI 244
            .|...| ||.:  ..|||....:.|:|.|:.|....:|.|:..|...|......|:.|...:.||
Human   204 HQGSIQ-VDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVI 267

  Fly   245 EKRAKELLDMGE----PAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSF 304
            :.|..:|...||    ...|..:.||.|||||.| |..||.:::|.|::||:|.|.|||.:.:|:
Human   268 QLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISW 332

  Fly   305 VLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQ-TTQS 367
            :|||||..|:.|.|.|:|:..:..| .:...:.|:.:||....|||.||||..||..||: :|..
Human   333 ILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPV 397

  Fly   368 TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIG 432
            |...||:...|:.:.:::|||.|:.:.:|:|..|.|.|:.|   ..|..:.:::|||||...|||
Human   398 TFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAP---GSAQHSHAFLPFSGGSRNCIG 459

  Fly   433 RRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINV 478
            :::::..:|:.||..:..|::...|.:.|:.: |::|||::.||::
Human   460 KQFAMNELKVATALTLLRFELLPDPTRIPIPI-ARLVLKSKNGIHL 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	141/439 (32%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	141/446 (32%)