Protein Alignment Cyp311a1 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 135/513 - (26%)
• Similarity: 229/513 - (44%)
• Gaps: 67/513 - (13%)

  Fly     1 MALWPLLLITLTIWILVRKWT---LLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVF-TELRD 61
            |..|.||.::|.:..|....:   ..:||  :|||...|.|||.....|     .|.:| .|...
Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKLG--IPGPTPLPFLGNILSYHK-----GFCMFDMECHK 66

  Fly    62 RFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------DTFMQLEPL--IG---NGLLIS 114
            ::|         ::|.| :..::...|:.||.:.|.       ..|....|.  :|   :.:.|:
Human    67 KYG---------KVWGF-YDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA 121

  Fly   115 HGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL--GATRGAFLEVTEPLFACLLDAIVD 177
            ....|.|.|.||:|.|....|:...|.|..:.:.||..|  .|..|..:.:.:...|..:|.|..
Human   122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186

  Fly   178 TSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIH----- 237
            ||.|..:|:.:....|.::.   :.|||....::|...|..:|.      .|...|:|::
Human   187 TSFGVNIDSLNNPQDPFVEN---TKKLLRFDFLDPFFLSITVFP------FLIPILEVLNICVFP 242

  Fly   238 SQMESVIEKRAKELLDMGEPAGRAHN------LLDTLLLAKFEG-QSLSRREIRDEINTFVFAGV 295
            .::.:.:.|..|.:.:......:.|.      ::|:....:.|. ::||..|:..:...|:|||.
Human   243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307

  Fly   296 DTTTAAMSFVLYALAKFPETQTRLRKELQDVALDET-TDLDALNGLPYLEALIKEVLRLYTIVPT 359
            :||::.:||::|.||..|:.|.:|::|:..|..::. ...|.:..:.||:.::.|.|||:.|...
Human   308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372

  Fly   360 TGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFS 424
            ..|...:..||.|.....||.:.|..|.|..|.:|:.:|..|.|||:..::.....| :.|.||.
Human   373 LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP-YIYTPFG 436

  Fly   425 GGPHVCIGRRYSLLLMKLLTARLVREFQMELSPE-QAPLRL--------EAQMVLKAQ 473
            .||..|||.|::|:.|||...|:::.|..:...| |.||:|        |..:|||.:
Human   437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	116/446 (26%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	114/444 (26%)