Protein Alignment Cyp311a1 and CYP3A7

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_000756.3
• Gene: CYP3A7 / 1551
• HGNCID: 2640
• Length: 503
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 135/505 - (26%)
• Similarity: 226/505 - (44%)
• Gaps: 57/505 - (11%)

  Fly     4 WPLLLITLTIWILVRKWT---LLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGA 65
            |.||.::|.:..|....|   ..:||  :|||...|.||||....|....:....:.:.|..:|
Human    12 WLLLAVSLILLYLYGTRTHGLFKKLG--IPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWG- 73

  Fly    66 TYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------DTFMQLEPL--IG---NGLLISHGAH 118
                         ::..::...|:.||.:.|.       ..|....|.  :|   |.:.|:....
Human    74 -------------IYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEE 125

  Fly   119 WTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRL--GATRGAFLEVTEPLFACLLDAIVDTSMG 181
            |.|.|.||:|.|....|:...|.|..:.:.||..|  .|..|..:.:.....|..:|.|..||.|
Human   126 WKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFG 190

  Fly   182 AQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQ-RTQLWRDLDEQLQVIHSQMESVIE 245
            ..:|:.:....|.::.   :.|||....::|.:.|..:|. .|.:...|:  :.|...::.|.:.
Human   191 VSIDSLNNPQDPFVEN---TKKLLRFNPLDPFVLSIKVFPFLTPILEALN--ITVFPRKVISFLT 250

  Fly   246 KRAKELLDMGEPAGRAHNLLDTLLLAKFEG-------QSLSRREIRDEINTFVFAGVDTTTAAMS 303
            |..|::.:......:.|.:....|:...:.       ::||..|:..:...|:|||.:||::.:|
Human   251 KSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLS 315

  Fly   304 FVLYALAKFPETQTRLRKELQDVALDET-TDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQS 367
            |::|.||..|:.|.:::||:..|..::. ...|.:..|.||:.::.|.|||:.:.....|...:.
Human   316 FIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKD 380

  Fly   368 TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIG 432
            .||.|.....||.:.|..|.|.||.:|:.:|..|.|||:..::.....| :.|.||..||..|||
Human   381 VEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDP-YIYTPFGSGPRNCIG 444

  Fly   433 RRYSLLLMKLLTARLVREFQMELSPE-QAPLRL--------EAQMVLKAQ 473
            .|::|:.|||...|:::.|..:...| |.||:|        |..:||||:
Human   445 MRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	117/442 (26%)
CYP3A7	NP_000756.3	CYP3A	67..492	CDD:410743	115/444 (26%)