DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	121/507 - (23%)
Similarity:	218/507 - (42%)	Gaps:	89/507 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLLLITLTIWILVRKWTLLRLGSS--------LPGPWAFPLLGNA-QMVGKLRPEYIFLVFTEL- 59
            ||||....:    :.|.|..:.|.        .||...||..|.. |||.:.|.      |.::
  Rat    17 PLLLFLAAL----KLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQRRK------FLQMK 71

  Fly    60 RDRFGATYRLRLGPQLWVFLHSAEETRQAL---------HDPTLRKADTFMQLEPLIGNGLLIS- 114
            |.::|..|:..|..:..|.:..|:..|:.|         |.|.        .:..::|.|.|.:
  Rat    72 RRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPA--------SVRTILGAGCLSNL 128

  Fly   115 HGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLVGRLG-----ATRG--AFLEVTEPLFACLL 172
            |.:...::::::..||..:.|:.:.|.|   .|.:.|.|.     ..||  .:.||...:|...:
  Rat   129 HDSSHKQRKKVIMQAFNREALQCYVPVI---AEEVSGCLEQWLSCGERGLLVYPEVKRLMFRIAM 190

  Fly   173 DAIVDTSMGAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIH 237
            ..::....|.....:  |...:::||...::.||...|:...|.        |:|.:..: .:||
  Rat   191 RILLGCEPGPAGGGE--DEQQLVEAFEEMTRNLFSLPIDVPFSG--------LYRGVKAR-NLIH 244

  Fly   238 SQMESVIEKRAKELLDMGEPAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAA 301
            :::|..|..:.:. |...||.....:.|..|:...:| |:.|..:.::......:|.|.:||.:|
  Rat   245 ARIEENIRAKIRR-LQAAEPDAGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASA 308

  Fly   302 MSFVLYALAKFPETQTRLRKELQDVAL------DETTDLDALNGLPYLEALIKEVLRLYTIVPTT 360
            .:.::..|..:|....::|:|::...|      ::..|::.|..|.|:..:|||.|||...||..
  Rat   309 ATSLITYLGLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKETLRLNPPVPGG 373

  Fly   361 GRQTTQSTEIGGRTYCAGVTLWINMYGL--AHD-KEYYPDPYAFKPERWL---PEDGAVAPPAFS 419
            .|...::.|:.|.....|   |..:|.:  .|| .:.:.:...|.|:|:.   |||.:    .||
  Rat   374 FRVALKTFELNGYQIPKG---WNVIYSICDTHDVADSFTNKEEFNPDRFTSLHPEDTS----RFS 431

  Fly   420 YIPFSGGPHVCIGRRYSLLLMKLLTARLVR--EFQ-------MELSPEQAPL 462
            :|||.||...|:|:.::.:|:|:.|..|.|  ::|       |:.||...|:
  Rat   432 FIPFGGGLRSCVGKEFAKILLKIFTVELARRCDWQLLNGPPTMKTSPPVYPV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	114/474 (24%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000