DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	514	Identity:	153/514 - (29%)
Similarity:	258/514 - (50%)	Gaps:	55/514 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALWP---LLLITL--TIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR 60
            :.||.   :|::|:  .:.:|.|:..|.|...|.|||....|.|:|..:.|.......:.:||
Mouse    13 LGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTE-- 75

  Fly    61 DRFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKA-------------DTFMQLEPLIGNGLL 112
             :|...:.|.|| |..|||:        :::|...||             |.|:|   .||.|||
Mouse    76 -QFPYAHPLWLG-QFIVFLN--------IYEPDYAKAVYSRGDPKAAYVYDFFLQ---WIGKGLL 127

  Fly   113 ISHGAHWTRQRRLLTPAFQPQLLRSFAPAIGGHVERLV---GRLGATRGAFLEVTEPLFACLLDA 174
            :..|..|.:.|:||||.|...:|:.:. ||.....|::   ....|:.....::...:....||.
Mouse   128 VLEGPKWFQHRKLLTPGFHYDVLKPYV-AIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDT 191

  Fly   175 IVDTSMGAQLDTQSVDHSPIIQAFHLSSK---LLFKRMINPL-LSSDWIFQRTQLWRDLDEQLQV 235
            ::..:.|.  ....:.||.  .:::|:..   ||.::.|:.. ..:|:|:..|...|......|:
Mouse   192 LMKCTFGK--GDSGLSHSD--NSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQI 252

  Fly   236 IHSQMESVIEKRAKELLDMGEP---AGRAH-NLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGV 295
            .|...:.||.:|...|.|..|.   ..|.| :.||.||.|:.| |..||..::|.|::||:|.|.
Mouse   253 AHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGH 317

  Fly   296 DTTTAAMSFVLYALAKFPETQTRLRKELQDVALD-ETTDLDALNGLPYLEALIKEVLRLYTIVPT 359
            ||||:.:|:.||.:|.:|..|.|.|:|::::..| ::...|.|..:.||...:||..|||..||.
Mouse   318 DTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDLAQMTYLTMCMKECFRLYPPVPQ 382

  Fly   360 TGRQTTQS-TEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPF 423
            ..||.::. |.:.||:..||..:.:::|.|..:...:|||..|.|.|:.||:.....| |:::||
Mouse   383 VYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHP-FAFMPF 446

  Fly   424 SGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            |.||..|||:::::..||::||..:..|:....|.:.|::: .|::|:::.||:: :||
Mouse   447 SAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKV-PQLILRSKNGIHL-YLK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	142/476 (30%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	142/474 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.770