DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	515	Identity:	151/515 - (29%)
Similarity:	251/515 - (48%)	Gaps:	66/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 WPLLLITLTI------WILVRKWTL--LRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELR 60
            |..||....:      :.|.|:|.|  |:....:|..|   |.|:.....:|:...|::
Mouse    21 WAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHW---LWGHHLKDKELQQILIWV------ 76

  Fly    61 DRF-GATYRLRLGPQLWVFLHSAEETRQAL--HDPTLRKADTFMQ-LEPLIGNGLLISHGAHWTR 121
            ::| .|..:...|..:.|.|:..:..:..|  .||   ||....| ..|.||.|||:.:|..|.:
Mouse    77 EKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRSDP---KASGIYQFFAPWIGYGLLLLNGKKWFQ 138

  Fly   122 QRRLLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPL--FACLLDAIVD 177
            .||:|||||...:|:.:...:...|       |:|.|:           ..||  |.|:....:|
Mouse   139 HRRMLTPAFHYDILKPYVKIMADSVNIMLDKWEKLDGQ-----------DHPLEIFHCVSLMTLD 192

  Fly   178 TSM--------GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQ 234
            |.|        ..|||..|..::..::..   :.|.|.|:.|.....:.|:..:...|......|
Mouse   193 TVMKCAFSYQGSVQLDENSKLYTKAVEDL---NNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQ 254

  Fly   235 VIHSQMESVIEKRAKELL---DMGEPAGRAH-NLLDTLLLAKFEGQ-SLSRREIRDEINTFVFAG 294
            :.|...:.||:.|..:|.   ::.:...:.| :.||.||.|:.|.: |||..::|.|::||:|.|
Mouse   255 IAHEHTDGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFARMEDRNSLSDEDLRAEVDTFMFEG 319

  Fly   295 VDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDETT-DLDALNGLPYLEALIKEVLRLYTIVP 358
            .|||.:.:|::.||||..||.|.|.|:|:|.:..|.|: ..|.|..:||....|||.||||..|.
Mouse   320 HDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVTWDHLGQMPYTTMCIKEALRLYPPVI 384

  Fly   359 TTGRQ-TTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIP 422
            :..|: ::..|...||:...|:|..|::|||.|:..::|:|..|.|.|:.|:.   :..:.:|:|
Mouse   385 SVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFWPNPKVFDPSRFAPDS---SHHSHAYLP 446

  Fly   423 FSGGPHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            ||||...|||:::::..:|:..|..:..|::...|.:.|:.: |::|||::.||::...|
Mouse   447 FSGGSRNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPI-ARLVLKSKNGIHLCLKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	142/477 (30%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	142/478 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810