DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp311a1 and Cyp4a12b

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_758510.2	Gene:	Cyp4a12b / 13118	MGIID:	3611747	Length:	508	Species:	Mus musculus

Alignment Length:	509	Identity:	150/509 - (29%)
Similarity:	253/509 - (49%)	Gaps:	62/509 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLR 70
            |||:..|..:.:.:..||......|.|.:..|.|:.    .|:.:.:..:.|.:::...|.
Mouse    28 LLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHK----ILKDQDLQDILTRIKNFPSAC---- 84

  Fly    71 LGPQ-LWVFLHSAEETRQALHDP-----TLRKAD-----TFMQLEPLIGNGLLISHGAHWTRQRR 124
              || ||     ..:.|..::||     .|.::|     ::..|.|.||.|||:..|..|.:.||
Mouse    85 --PQWLW-----GSKVRIQVYDPDYMKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRR 142

  Fly   125 LLTPAFQPQLLRSFAPAIGGHV-------ERLVGRLGATRGAFLEVTEPLFACLLDAIVDTSM-- 180
            :|||||...:|:.:...:...|       |::||     :.:.||:.:.:....||.|:..:.
Mouse   143 MLTPAFHYDILKPYTEIMADSVHVMLDKWEQIVG-----QDSTLEIFQHITLMTLDTIMKCAFSH 202

  Fly   181 --GAQLDTQSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESV 243
              ..|||.:   :...|||....:.|.|.|:.|....:|.|::.:......:...|:.|...:.|
Mouse   203 EGSVQLDRK---YKSYIQAVEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQV 264

  Fly   244 IEKRAKELLDMGE----PAGRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMS 303
            |:.|..:|.|..|    ...|..:.||.||.|:.| |:|||.:::|.|::||:|.|.|||.:.:|
Mouse   265 IKSRRSQLQDEEELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGIS 329

  Fly   304 FVLYALAKFPETQTRLRKELQDVALDETT----DLDALNGLPYLEALIKEVLRLYTIVPTTGRQ- 363
            ::.||||..||.|.|.|||:|.:..|..:    |||.   :||....|||.||:|..||:..|:
Mouse   330 WIFYALATNPEHQQRCRKEIQSLLGDGASITWNDLDK---MPYTTMCIKEALRIYPPVPSVSREL 391

  Fly   364 TTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPH 428
            ::..|...||:...|:.:.::.|||.|:...:|:|..|.|.|:.|   ..:..:.|::|||||..
Mouse   392 SSPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAP---GSSRHSHSFLPFSGGAR 453

  Fly   429 VCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGINVSFLK 482
            .|||:::::..:|:..|..:..|::...|.:.|:.: .::|||::.||::...|
Mouse   454 NCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPI-PRIVLKSKNGIHLHLKK 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	143/481 (30%)
Cyp4a12b	NP_758510.2	CYP4B-like	70..503	CDD:410771	138/458 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810