DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp311a1 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	485	Identity:	113/485 - (23%)
Similarity:	204/485 - (42%)	Gaps:	85/485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLLLITLTIWILVRKWTLLRLGSSLPGPWAFPLLGNAQMVGKLRPEYIFL---------VFTELR 60
            |||||   :.:|:..|. ....||:|||      |....:|.|.....||         .:.::.
Mouse    27 PLLLI---MGLLLLIWN-CESSSSIPGP------GYCLGIGPLISHGRFLWMGIGSACNYYNKMY 81

  Fly    61 DRFGATYRLRLGPQLWVFLHSAEET----------RQALHDPTLRKADTFMQLEPLIG---NGLL 112
            ..|         .::|:   |.|||          ....|...:.:..:...|: .||   ||::
Mouse    82 GEF---------MRVWI---SGEETLIISKSSSMFHVMKHSHYISRFGSKRGLQ-CIGMHENGII 133

  Fly   113 ISHG-AHWTRQRRLLTPAFQ-----PQLLRSF---APAIGGHVERLVGRLGATRGAFLEVTEPLF 168
            .::. :.|    |.:.|.|.     |.|:|..   ..:|..|::|| |.:..|.| :::|...:.
Mouse   134 FNNNPSLW----RTIRPFFMKALTGPGLVRMVEVCVESIKQHLDRL-GEVTDTSG-YVDVLTLMR 192

  Fly   169 ACLLDAIVDTSMGAQLDTQSVDHSPIIQA-FHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQ 232
            ..:||......:|..||..::...  ||. |:....||.|..|        .|:.:.|:|..:..
Mouse   193 HIMLDTSNMLFLGIPLDESAIVKK--IQGYFNAWQALLIKPNI--------FFKISWLYRKYERS 247

  Fly   233 LQVIHSQMESVIEKRAKELLDMGEPAGRAHNLLD---TLLLAKFEGQSLSRREIRDEINTFVFAG 294
            ::.:..::..::||:..::    ..|.:..:.:|   .|:.|:..| .|::..:...|...:.|.
Mouse   248 VKDLKDEIAVLVEKKRHKV----STAEKLEDCMDFATDLIFAERRG-DLTKENVNQCILEMLIAA 307

  Fly   295 VDTTTAAMSFVLYALAKFPETQTRLRKELQDVALDETTDLDALNGLPYLEALIKEVLRLYTIVPT 359
            .||.:..:.|:|..:|::||.:..:.||:..|..|....::.:..|..:|..|.|.:|...:|..
Mouse   308 PDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDL 372

  Fly   360 TGRQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFS 424
            ..|:..:...|.|.....|..:.:|: |..|..||:|.|..|..|.:  |...   |...:.||.
Mouse   373 VMRRALEDDVIDGYPVKKGTNIILNI-GRMHRLEYFPKPNEFTLENF--EKNV---PYRYFQPFG 431

  Fly   425 GGPHVCIGRRYSLLLMKLLTARLVREFQME 454
            .||..|.|:..::::||::...|:|.||::
Mouse   432 FGPRGCAGKYIAMVMMKVVLVTLLRRFQVK 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	104/460 (23%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	104/460 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010