Protein Alignment Cyp311a1 and CYP4F22

DIOPT Version :10

• Sequence 1: NP_572780.3
• Gene: Cyp311a1 / 32170
• FlyBaseID: FBgn0030367
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_775754.2
• Gene: CYP4F22 / 126410
• HGNCID: 26820
• Length: 531
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 135/496 - (27%)
• Similarity: 233/496 - (46%)
• Gaps: 77/496 - (15%)

  Fly    18 RKWTLLRLGSSLPGP-------------------WAFPLLGNAQMVGKLRPEYIFLVFTELRDRF 63
            |.|.|..||..||..                   |..|:|   .::..:.|:||       :...
Human    65 RNWLLGHLGMYLPNEAGLQDEKKVLDNMHHVLLVWMGPVL---PLLVLVHPDYI-------KPLL 119

  Fly    64 GATYRLRLGPQLWVFLHSAEETRQALHDPTLRKADTFMQ-LEPLIGNGLLISHGAHWTRQRRLLT 127
            ||:  ..:.|                      |.|.|.. |:|.:|:|||:|.|..|:|.|||||
Human   120 GAS--AAIAP----------------------KDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLT 160

  Fly   128 PAFQPQLLRSFAPAIGGHVERLVGR---LGATRGAFLEVTEPLFACLLDAIVDT--SMGAQLDTQ 187
            |||...:|:.:........:.:..:   |.......|::.|.:....||::...  |..:....:
Human   161 PAFHFDILKPYMKIFNQSADIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQEK 225

  Fly   188 SVDH-SPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLWRDLDEQLQVIHSQMESVIEKRAKEL 251
            ..|: |.||:...||.:..::  ::..|  |:|:.|:...|...:...::|.....||::|.:.|
Human   226 MSDYISAIIELSALSVRRQYR--LHHYL--DFIYYRSADGRRFRQACDMVHHFTTEVIQERRRAL 286

  Fly   252 LDMGEPA------GRAHNLLDTLLLAKFE-GQSLSRREIRDEINTFVFAGVDTTTAAMSFVLYAL 309
            ...|..|      |:..:.:|.||||:.| |:.||..:||.|.:||:|.|.|||::.:|::|:.|
Human   287 RQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMFEGHDTTSSGISWMLFNL 351

  Fly   310 AKFPETQTRLRKELQDVALD---ETTDLDALNGLPYLEALIKEVLRLYTIVPTTGRQTTQSTEI- 370
            ||:||.|.:.|:|:|:|...   |..:.|.|..||:....|||.||.|..|....||.|:..::
Human   352 AKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLP 416

  Fly   371 GGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGGPHVCIGRRY 435
            .||....|:...:::||..|:...:||...:.|.|:.|::.....| .:|:|||.||..|||:.:
Human   417 DGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPYRFDPDNPQQRSP-LAYVPFSAGPRNCIGQSF 480

  Fly   436 SLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            ::..::::.|..:..|::.:. ....:|.:.:::|:.:.|:
Human   481 AMAELRVVVALTLLRFRLSVD-RTRKVRRKPELILRTENGL 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	cytochrome_P450	64..478	CDD:477761	122/431 (28%)
CYP4F22	NP_775754.2	CYP4F	82..523	CDD:410772	128/479 (27%)