DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp311a1 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_598730.1	Gene:	Cyp4v3 / 102294	MGIID:	2142763	Length:	525	Species:	Mus musculus

Alignment Length:	505	Identity:	155/505 - (30%)
Similarity:	250/505 - (49%)	Gaps:	51/505 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALWPLLLITLTIWILVRKWTLLRLGSSLPG-PWAFPLLGNAQMVGKLRPEYI--FLVFTELRDR 62
            ::::|:|:      ...|||..:|   |:|. ..|:||:|:|..:.....|:.  .:.:|| ..|
Mouse    31 ISIFPMLV------SYARKWQQMR---SIPSVARAYPLVGHALYMKPNNAEFFQQLIYYTE-EFR 85

  Fly    63 FGATYRLRLGPQLWVFLHSAEETRQAL-HDPTLRKADTFMQLEPLIGNGLLISHGAHWTRQRRLL 126
            .....:|.:||...|.|:.||.....| ....:.|:..:..|:|.:|.|||.|.|:.|..:|::|
Mouse    86 HLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKML 150

  Fly   127 TPAFQPQLLRSFAPAIGGHVERLVGRL-----GATRGAFLEVTEPLFACLLDAIVDTSMGAQLDT 186
            ||.|...:|.:|...:......||.:|     ......|..:|    .|.||.|.:|:||..:..
Mouse   151 TPTFHFTILENFLDVMNEQANILVNKLEKHVNQEAFNCFFYIT----LCALDIICETAMGKNIGA 211

  Fly   187 QSVDHSPIIQAFHLSSKLLFKRMINPLLSSDWIFQRTQLW-------RDLDEQLQVIHSQMESVI 244
            ||.:.|..::..:..|.::::||..|.|   |.    .||       ||....|:.:|:...:||
Mouse   212 QSNNDSEYVRTVYRMSDMIYRRMKMPWL---WF----DLWYLVFKEGRDHKRGLKCLHTFTNNVI 269

  Fly   245 EKRAKELLDMGEPAGRAHN----------LLDTLL-LAKFEGQSLSRREIRDEINTFVFAGVDTT 298
            .:|.||.....:..|....          .||.|| :...||..||:.:||:|::||:|.|.|||
Mouse   270 AERVKERKAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTT 334

  Fly   299 TAAMSFVLYALAKFPETQTRLRKELQDV--ALDETTDLDALNGLPYLEALIKEVLRLYTIVPTTG 361
            .||:::.||.|...||.|.::.:||.:|  .......|:.|..|.||:.:|||.||::..||...
Mouse   335 AAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVFPSVPLFA 399

  Fly   362 RQTTQSTEIGGRTYCAGVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYIPFSGG 426
            |..::..|:||.....|....|..|.|..|..|:|||..|:|||:.||:.....| ::|:|||.|
Mouse   400 RSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQGRHP-YAYVPFSAG 463

  Fly   427 PHVCIGRRYSLLLMKLLTARLVREFQMELSPEQAPLRLEAQMVLKAQQGI 476
            |..|||::::::..|.:.|.::|:|.:|.:.::..|.|...::|:...||
Mouse   464 PRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILRPNNGI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	148/476 (31%)
Cyp4v3	NP_598730.1	p450	51..517	CDD:278495	148/476 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910