Protein Alignment Usp7 and UBP15

DIOPT Version :9

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_014033.1
• Gene: UBP15 / 855350
• SGDID: S000004920
• Length: 1230
• Species: Saccharomyces cerevisiae
• Alignment Length: 1284
• Identity: 360/1284 - (28%)
• Similarity: 582/1284 - (45%)
• Gaps: 280/1284 - (21%)

  Fly    48 QPQLHAVGAV---TQLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVE 109
            :.:|.::|.|   :.:....|::.||                   .||..|...  |.:|::.:.
Yeast     4 EDELGSIGTVFPGSPIDKSIGSILPQ-------------------FDEEVETLL--EDSFTWNIP 47

  Fly   110 NVVQLKSQRLSPPVY-VRMLPWRIMVIP---NDRALGFFLQCNGEND-----------SPTWSCN 159
            :..:|.:.:.:.|.: :....|.|::.|   :::.:..:|:.:.|..           .|.|.|
Yeast    48 DWNELTNPKYNSPRFRIGDFEWDILLFPQGNHNKGVAVYLEPHPEEKLDETTGEMVPVDPDWYC- 111

  Fly   160 AIAELRLKCHKPDAQPFTRA--RIKHLFYSKENDYGYSNFITWQELKDSEK----SYVHNN--SI 216
             .|:..:...:|........  :..|.|.:.:.|:|::|.|....||...|    |:::..  :|
Yeast   112 -CAQFAIGISRPGNGDTINLINKSHHRFNALDTDWGFANLIDLNNLKHPSKGRPLSFLNEGTLNI 175

  Fly   217 TLEVHVVADAPHGVLW------DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTE 275
            |..|.::.| |.||||      ||||.|||||.:|||||||:|||||:.:||...|..||.||||
Yeast   176 TAYVRILKD-PTGVLWHNFLNYDSKKVTGYVGFRNQGATCYLNSLLQSYFFTKYFRKLVYEIPTE 239

  Fly   276 ADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKG 340
            .:..:.||.|:|||.|::||..|.|:.|.:||:||||:|.:||.||||||..|:|:|:||:.|||
Yeast   240 HESPNNSVPLALQRAFYQLQVSDIPLDTLELTRSFGWDTAESFTQHDVQELNRILMDRLENNMKG 304

  Fly   341 TILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNK 405
            |.:||.:..:|.|||.|||||.||||.|.|.|.|:|:|||:|:.||:.|||.:|:..|.:.|:|:
Yeast   305 TPVEGKLNEIFVGKMKSYIKCINVDYESARVEDFWDLQLNVKNFKNLQESFDNYIEMELMNGENQ 369

  Fly   406 YDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL------ 464
            |.|..:|||:|.|||||.||||||||.|.||:||...|..:|.||::||.|.|:|..::
Yeast   370 YAAQDYGLQDAQKGVIFESFPPVLHLQLKRFEYDFNYDQMVKVNDKYEFPETIDLSPFVDKDVLK 434

  Fly   465 --AESENTLAD---YVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNY 524
              .:|||...:   |.||.|||||||...|||...|.|..:.:|::|||:.|....|::..::|:
Yeast   435 KTLDSENKDKNPYVYNLHGVLVHSGDISTGHYYTLIKPGVEDQWYRFDDERVWRVTKKQVFQENF 499

  Fly   525 G--GMDDE--------------ISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDL 573
            |  .:.||              |..|   ::|||||||||.:.:.:|..:.||::...::.|:..
Yeast   500 GCDRLPDEKVRTMTRGEYQNYIIQRH---TSAYMLVYIRQEQEEDLLRPVLESDVPKHVITRVRE 561

  Fly   574 EKRIEMARRKERGEANTYVS--VHVILE----ENFE--EQHKRRLF-------DLEKVHPRVFRI 623
            |.:....:.||..||:.||:  :|.|.|    |.|:  .....|||       .|::::.:|.|
Yeast   562 EIKERETKEKEIREAHLYVTLRLHSIKEFIHYEGFDYFAHDGFRLFAEELNDSGLQQINLKVLR- 625

  Fly   624 KQNQTVDELVDLFV---RGFGVSRQR-MRMWNL-----CTAQTQKFSHFDFV---------AEGS 670
                 ..:|.|:|.   ....:.::| ::.|.:     .|.:..:..:|:.|         .|..
Yeast   626 -----TTKLSDIFASIKETMNIPQERDVKYWKMDYRRNSTLRLTQPINFESVNITLQEALKKEKK 685

  Fly   671 RTIEQ-------ISTSQKPWVI--------------WLQLAW----------------------- 691
            ||::.       .||.:....:              :|:|.:
Yeast   686 RTMQTQYGEEGVASTEEDDKALLETVSFLDLFIEEPYLELQFLNKLKEASLISKAQLDDELISTI 750

  Fly   692 -TDVP-----GPLPPFNPKTES-LLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFE 749
             |::|     |..|.|....:| |||:|.|||..::|...|.......::|.|:...:...:  .
Yeast   751 RTNLPELTKGGIEPVFATDNKSNLLFVKSYDPHTQKLLGFGHFAVNQLQQLSDISAIIEDSI--S 813

  Fly   750 PDTELTIYDEYADKKL--VNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLP---TVGDYFL 809
            .:.:||.|:|.....:  :.:.|.|..|     |...|.|:.||..........|   |:.|::.
Yeast   814 SNEKLTFYEEVQPGTINEIYMKETIYDA-----DIDTGDIVSFEVPGAVLPDTFPVYATIKDFYS 873

  Fly   810 DLVYRIEIIFSDKCNPNE--------PD-FTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCIN 865
            .|.||:::.||.....:|        |: |...:|....||.||..|::..:..|:.|:.....:
Yeast   874 YLRYRVKLKFSKFDGSSEEYGVSNEIPESFEFWISAYAPYDDLARMVSKYAHVKPEYLKIIALYS 938

  Fly   866 NYKETAGNAVPYTFKGT--IKDLVSYTKQSSTKRI---FYQRLSLSIHELDNKKQFKCVWVSSDL 925
            |.:        :..|.|  :.|.:  .|..:..:|   .::.||:.:.||:..:..|..|:.:..
Yeast   939 NGR--------FVLKSTSLLNDYL--LKDFNCDQIPPFAFEVLSVPLKELERLRPIKLYWLKNSY 993

  Fly   926 KD----EKELVLYPNKND-TVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKD-----DI 980
            ..    |.|:.     || |....||:...||.|.:..:..:.|...:|.:...:..|     |:
Yeast   994 IHYQCFEFEVA-----NDYTESQFLEKVQHKIGFTDEEKENILLWTNTNFQFQGLLSDQNTFKDV 1053

  Fly   981 PLDTLL---------KSNESITTAQGAQKTFRIEEV---------PAED-----MQLAENE---- 1018
            ...:||         |..:.:...:..| |..:|:.         |.:|     |.:..:|
Yeast  1054 SKHSLLFGRILPEESKLFKELNRLENVQ-TSSLEDFMDDENATDRPMDDEQDLGMAIEHSEDMKG 1117

  Fly  1019 FLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVN 1083
            .::.|..:.|:|.|..||.||......|.:...|.|:..:..:..||:...|   :|:|::.:
Yeast  1118 RIVVVQQYFKDLENRHGISFLFNLIPDETFPKTKDRLHAKFGLGQKEFSKIK---LSIGYSTE-- 1177

  Fly  1084 DNTPVDLEVYRSWTS---------------GQLPFFGLDHINKSRKRSS 1117
            :.|     |:||...               ..|.:..:||.::.|..||
Yeast  1178 EGT-----VFRSLQGFSDEELDKVILYDIMSNLDYIYMDHPDRLRSHSS 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	29/151 (19%)
		COG5077	101..1119	CDD:227409	351/1228 (29%)
		peptidase_C19C	239..549	CDD:239124	165/336 (49%)
		USP7_ICP0_bdg	647..886	CDD:289221	62/319 (19%)
		USP7_C2	897..1113	CDD:291217	54/270 (20%)
UBP15	NP_014033.1	COG5077	1..1229	CDD:227409	360/1284 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I211
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2592
Inparanoid	1	1.050	421	1.000	Inparanoid score	I287
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55761
OrthoFinder	1	1.000	-	-		FOG0003101
OrthoInspector	1	1.000	-	-		oto99919
orthoMCL	1	0.900	-	-		OOG6_101317
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2325
SonicParanoid	1	1.000	-	-		X2073
TreeFam	1	0.960	-	-
	14	13.860