Protein Alignment Usp7 and UBP15

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_014033.1
• Gene: UBP15 / 855350
• SGDID: S000004920
• Length: 1230
• Species: Saccharomyces cerevisiae
• Alignment Length: 1295
• Identity: 359/1295 - (27%)
• Similarity: 574/1295 - (44%)
• Gaps: 302/1295 - (23%)

  Fly    48 QPQLHAVGAV---TQLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVE 109
            :.:|.::|.|   :.:....|::.||                   .||..|...  |.:|::.:.
Yeast     4 EDELGSIGTVFPGSPIDKSIGSILPQ-------------------FDEEVETLL--EDSFTWNIP 47

  Fly   110 NVVQLKSQRLSPPVY-VRMLPWRIMVIP---NDRALGFFLQCNGEND-----------SPTWSCN 159
            :..:|.:.:.:.|.: :....|.|::.|   :::.:..:|:.:.|..           .|.|.|
Yeast    48 DWNELTNPKYNSPRFRIGDFEWDILLFPQGNHNKGVAVYLEPHPEEKLDETTGEMVPVDPDWYC- 111

  Fly   160 AIAELRLKCHKPDAQPFTRA--RIKHLFYSKENDYGYSNFITWQELKDSEK----SYVHNN--SI 216
             .|:..:...:|........  :..|.|.:.:.|:|::|.|....||...|    |:::..  :|
Yeast   112 -CAQFAIGISRPGNGDTINLINKSHHRFNALDTDWGFANLIDLNNLKHPSKGRPLSFLNEGTLNI 175

  Fly   217 TLEVHVVADAPHGVLW------DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTE 275
            |..|.::.| |.||||      ||||.|||||.:|||||||:|||||:.:||...|..||.||||
Yeast   176 TAYVRILKD-PTGVLWHNFLNYDSKKVTGYVGFRNQGATCYLNSLLQSYFFTKYFRKLVYEIPTE 239

  Fly   276 ADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKG 340
            .:..:.||.|:|||.|::||..|.|:.|.:||:||||:|.:||.||||||..|:|:|:||:.|||
Yeast   240 HESPNNSVPLALQRAFYQLQVSDIPLDTLELTRSFGWDTAESFTQHDVQELNRILMDRLENNMKG 304

  Fly   341 TILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNK 405
            |.:||.:..:|.|||.|||||.||||.|.|.|.|:|:|||:|:.||:.|||.:|:..|.:.|:|:
Yeast   305 TPVEGKLNEIFVGKMKSYIKCINVDYESARVEDFWDLQLNVKNFKNLQESFDNYIEMELMNGENQ 369

  Fly   406 YDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL------ 464
            |.|..:|||:|.|||||.||||||||.|.||:||...|..:|.||::||.|.|:|..::
Yeast   370 YAAQDYGLQDAQKGVIFESFPPVLHLQLKRFEYDFNYDQMVKVNDKYEFPETIDLSPFVDKDVLK 434

  Fly   465 --AESENTLAD---YVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNY 524
              .:|||...:   |.||.|||||||...|||...|.|..:.:|::|||:.|....|::..::|:
Yeast   435 KTLDSENKDKNPYVYNLHGVLVHSGDISTGHYYTLIKPGVEDQWYRFDDERVWRVTKKQVFQENF 499

  Fly   525 G--GMDDE--------------ISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDL 573
            |  .:.||              |..|   ::|||||||||.:.:.:|..:.||::...::.|:..
Yeast   500 GCDRLPDEKVRTMTRGEYQNYIIQRH---TSAYMLVYIRQEQEEDLLRPVLESDVPKHVITRVRE 561

  Fly   574 EKRIEMARRKERGEANTYVS--VHVILE----ENFE--EQHKRRLF-------DLEKVHPRVFRI 623
            |.:....:.||..||:.||:  :|.|.|    |.|:  .....|||       .|::::.:|.|
Yeast   562 EIKERETKEKEIREAHLYVTLRLHSIKEFIHYEGFDYFAHDGFRLFAEELNDSGLQQINLKVLR- 625

  Fly   624 KQNQTVDELVDLFV---RGFGVSRQR-MRMWNL-------------------------------- 652
                 ..:|.|:|.   ....:.::| ::.|.:
Yeast   626 -----TTKLSDIFASIKETMNIPQERDVKYWKMDYRRNSTLRLTQPINFESVNITLQEALKKEKK 685

  Fly   653 CTAQTQ--------------------------------------KFSHFDFVAEGSRTIEQISTS 679
            .|.|||                                      |......:::.....|.|||.
Yeast   686 RTMQTQYGEEGVASTEEDDKALLETVSFLDLFIEEPYLELQFLNKLKEASLISKAQLDDELISTI 750

  Fly   680 QKPWVIWLQLAWTDVP-----GPLPPFNPKTES-LLFLKYYDPRNKRLNYIGCTQQPHTRRLIDL 738
            :           |::|     |..|.|....:| |||:|.|||..::|...|.......::|.|:
Yeast   751 R-----------TNLPELTKGGIEPVFATDNKSNLLFVKSYDPHTQKLLGFGHFAVNQLQQLSDI 804

  Fly   739 VPDVNSKLGFEPDTELTIYDEYADKKL--VNLNEPIESALFIPQDHLQGHILIFERENVDAKLDL 801
            ...:...:  ..:.:||.|:|.....:  :.:.|.|..|     |...|.|:.||..........
Yeast   805 SAIIEDSI--SSNEKLTFYEEVQPGTINEIYMKETIYDA-----DIDTGDIVSFEVPGAVLPDTF 862

  Fly   802 P---TVGDYFLDLVYRIEIIFSDKCNPNE--------PD-FTLELSNRYNYDQLANAVAERLNTD 854
            |   |:.|::..|.||:::.||.....:|        |: |...:|....||.||..|::..:..
Yeast   863 PVYATIKDFYSYLRYRVKLKFSKFDGSSEEYGVSNEIPESFEFWISAYAPYDDLARMVSKYAHVK 927

  Fly   855 PQKLQFFMCINNYKETAGNAVPYTFKGT--IKDLVSYTKQSSTKRI---FYQRLSLSIHELDNKK 914
            |:.|:.....:|.:        :..|.|  :.|.:  .|..:..:|   .::.||:.:.||:..:
Yeast   928 PEYLKIIALYSNGR--------FVLKSTSLLNDYL--LKDFNCDQIPPFAFEVLSVPLKELERLR 982

  Fly   915 QFKCVWVSSDLKD----EKELVLYPNKND-TVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVA 974
            ..|..|:.:....    |.|:.     || |....||:...||.|.:..:..:.|...:|.:...
Yeast   983 PIKLYWLKNSYIHYQCFEFEVA-----NDYTESQFLEKVQHKIGFTDEEKENILLWTNTNFQFQG 1042

  Fly   975 VCKD-----DIPLDTLL---------KSNESITTAQGAQKTFRIEEV---------PAED----- 1011
            :..|     |:...:||         |..:.:...:..| |..:|:.         |.:|
Yeast  1043 LLSDQNTFKDVSKHSLLFGRILPEESKLFKELNRLENVQ-TSSLEDFMDDENATDRPMDDEQDLG 1106

  Fly  1012 MQLAENE----FLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFC 1072
            |.:..:|    .::.|..:.|:|.|..||.||......|.:...|.|:..:..:..||:...|
Yeast  1107 MAIEHSEDMKGRIVVVQQYFKDLENRHGISFLFNLIPDETFPKTKDRLHAKFGLGQKEFSKIK-- 1169

  Fly  1073 VISMGHNADVNDNTPVDLEVYRSWTS---------------GQLPFFGLDHINKSRKRSS 1117
             :|:|::.:  :.|     |:||...               ..|.:..:||.::.|..||
Yeast  1170 -LSIGYSTE--EGT-----VFRSLQGFSDEELDKVILYDIMSNLDYIYMDHPDRLRSHSS 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	350/1239 (28%)
UBP15	NP_014033.1	COG5077	1..1229	CDD:227409	359/1295 (28%)