DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and UBP2

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_014767.3	Gene:	UBP2 / 854291	SGDID:	S000005650	Length:	1272	Species:	Saccharomyces cerevisiae

Alignment Length:	714	Identity:	132/714 - (18%)
Similarity:	224/714 - (31%)	Gaps:	265/714 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 EAMDTQDTQEVEILTSDLQQTQQQRNSPPQLPKFK------NLIQPQLHAV--GAVTQLPSE--- 63
            |.:|.|:..:       |.|..:..:....|..||      |:.:|....:  .|:|::..|
Yeast   655 EKLDYQEALK-------LLQVNENASDETILKIFKQKWFDENVYEPDQFLILRAALTKISIERNS 712

  Fly    64 --------NGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTV----------EN 110
                    .|.:.|..|..::..|        ||::........|...:.|::          :.
Yeast   713 TLITNFLLTGTIDPNSLPPENWPT--------GINNIGNTCYLNSLLQYYFSIAPLRRYVLEYQK 769

  Fly   111 VVQLKSQRLSPPVYVRMLPWR-IMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQ 174
            .|:..:..||...::|.:..| |.....:|::.|..|...       ...|:...|.:|..|..:
Yeast   770 TVENFNDHLSNSGHIRRIGGREISRGEVERSIQFIYQLRN-------LFYAMVHTRERCVTPSKE 827

  Fly   175 PFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHV----VADAPHGVLWDSK 235
                  :.:|.::..|                         :.:|..|    |.|.. |||.|||
Yeast   828 ------LAYLAFAPSN-------------------------VEVEFEVEGNKVVDQT-GVLSDSK 860

  Fly   236 KHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSV----YRIPTEADDSSKS-----VGLSLQRVF 291
            |.|    ..:...|...::.|..|...:.|...|    .|...|::|:..|     .||:
Yeast   861 KET----TDDAFTTKIKDTSLIDLEMEDGLNGDVGTDANRKKNESNDAEVSENEDTTGLT----- 916

  Fly   292 HELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMS 356
                   .|....|::.......|:...|.||.|.:..:|.::||        |:.|..::....
Yeast   917 -------SPTRVAKISSDQLENALEMGRQQDVTECIGNVLFQIES--------GSEPIRYDEDNE 966

  Fly   357 SYIKCKNVDYNS---------------TRYETFYDIQLNIKD-KKNIYESFQDYVAPETLEGDNK 405
            .|...|.:.|.:               |:.|.|..:.:||.| .|:||::|..|...|.|..:..
Yeast   967 QYDLVKQLFYGTTKQSIVPLSATNKVRTKVERFLSLLINIGDHPKDIYDAFDSYFKDEYLTMEEY 1031

  Fly   406 YDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENT 470
            .|        ..:.|..|:||.:|.:.:.|..||.......|..:...|.|.|.:||| |::||.
Yeast  1032 GD--------VIRTVAVTTFPTILQVQIQRVYYDRERLMPFKSIEPLPFKEVIYMDRY-ADTENP 1087

  Fly   471 LA--------------------------------------------------------------- 472
            |.
Yeast  1088 LLLAKKKETEEMKQKLKVMKNRQRELLSRDDSGLTRKDAFLESIKLLESDTIKKTPLKIEAANDV 1152

  Fly   473 ---------------------------------------DYVLHAVLVHSGDNHGGHYVVFINPK 498
                                                   .|.|.:|.:|.|:...|||.::|..:
Yeast  1153 IKTLRNNVQNIDNELMKLYNDINSLEEKISHQFDDFKEYGYSLFSVFIHRGEASYGHYWIYIKDR 1217

  Fly   499 -ADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSE------LDRVL 555
             .:|.|.|::|:.:|..:::|....|.|          ..:..|.|||::|.:      |.|:|
Yeast  1218 NRNGIWRKYNDETISEVQEEEVFNFNEG----------NTATPYFLVYVKQGQEGDIEPLKRIL 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	21/143 (15%)
		COG5077	101..1119	CDD:227409	112/604 (19%)
		peptidase_C19C	239..549	CDD:239124	80/437 (18%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
UBP2	NP_014767.3	RPT	585..641	CDD:404348
		RPT	658..719	CDD:404348	12/67 (18%)
		Peptidase_C19J	735..1256	CDD:239131	111/610 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000