Protein Alignment Usp7 and USP9X

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_001397677.1
• Gene: USP9X / 8239
• HGNCID: 12632
• Length: 2575
• Species: Homo sapiens
• Alignment Length: 1072
• Identity: 227/1072 - (21%)
• Similarity: 369/1072 - (34%)
• Gaps: 309/1072 - (28%)

  Fly   239 GYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIP------------TEADDSSKSVGLSLQRVF 291
            |:|||||.||||||||::|.||...|:|..:..|.            .|..|:..:|........
Human  1560 GFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFG 1624

  Fly   292 HELQFGDRPVGTK-------------KLTKSFG---------------------W-ETLDSFMQH 321
            :..||.|:|..:|             .|...||                     | |.::...||
Human  1625 YPQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNLREQH 1689

  Fly   322 DVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKN 386
            |..||...|:|.|:..:|.......:..:..|..:....|:...:.....|:|..:.::|::.:|
Human  1690 DALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQN 1754

  Fly   387 IYESFQDYVAPETLEGDNKYDAGVHGLQEASKGV------IFTSFPPVLHLHLMRFQYDPVTDSS 445
            :.:|.:.||..:.|||.|.|..     ::.:|.|      :....||||.:.|.||.||...:.:
Human  1755 LLDSLEQYVKGDLLEGANAYHC-----EKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECA 1814

  Fly   446 IKYNDRFEFYEHINLDRY-------------------LAESENTLAD------YVLHAVLVHSGD 485
            ||:||.|||...::::.|                   :.:||.:.::      |.|..||||||.
Human  1815 IKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGSTKYRLVGVLVHSGQ 1879

  Fly   486 NHGGHYVVFINPKADG-----RWFKFDDDVVSSCR---KQEAIEQNYGG---------MDDEISF 533
            ..||||..:|..:..|     ||:||||..|:.|:   .:|...|.:||         |...:|:
Human  1880 ASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSY 1944

  Fly   534 --HAKCSNAYMLVYIRQSELDR---VLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVS 593
              ..:..|||:|.|.|...:|:   ::..|:|..|:: ...::.:...||.:.||
Human  1945 RRQKRWWNAYILFYERMDTIDQDDELIRYISELAITT-RPHQIIMPSAIERSVRK---------- 1998

  Fly   594 VHVILEENFEEQHKRRLFDLEKVHPRVFRIK--------------QNQTVDELVD---------- 634
                  :|.:..|.|..:.:|...   |..|              |:..:.|..:
Human  1999 ------QNVQFMHNRMQYSMEYFQ---FMKKLLTCNGVYLNPPPGQDHLLPEAEEITMISIQLAA 2054

  Fly   635 --LFVRGFGVSR--------------------QRMRMW---NLCTAQTQKFSHFDFVAEGSRTIE 674
              ||..||...:                    :.:|.|   |:....:.:||  :::.| ..:.|
Human  2055 RFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRFS--EYLLE-CPSAE 2116

  Fly   675 QISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKR-------LNYIGCTQQPHT 732
            ......|..|.....:..|.|.|.|..:|...|    :.||..:..       ||.:......|.
Human  2117 VRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSS----QAYDNLSLSDHLLRAVLNLLRREVSEHG 2177

  Fly   733 RRL---IDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNE----PIE------SALFIPQDHLQ 784
            |.|   .:|.. :.:.||....|:|......|...||:|:|    ||:      ..|:.....|.
Human  2178 RHLQQYFNLFV-MYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKYQYAELGKLYSVVSQLI 2241

  Fly   785 GHILIFER--ENVDAKLDLP-----------------TVGDYFLDLVYRIEIIFSDKCNPNE--- 827
            ....:..|  .:::....||                 .|.|........::.|..|..|..|
Human  2242 RCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILFVRTSYVKKIIEDCSNSEETVK 2306

  Fly   828 ---------PDFTLELSNR------YNYDQLANAVAERLNTDPQKLQFFMCINNYK----ETAGN 873
                     |.|:..:.:.      |:|........:.|      ||..:..::::    ..|..
Human  2307 LLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLL------LQILLIEDSWQTHRIHNALK 2365

  Fly   874 AVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDN--------------KKQFKCVWVSSD 924
            .:|....| :.|.:..:|....||. ||.:...:....|              |:  |..|....
Human  2366 GIPDDRDG-LFDTIQRSKNHYQKRA-YQCIKCMVALFSNCPVAYQILQGNGDLKR--KWTWAVEW 2426

  Fly   925 LKDEKELVLYP--------------NKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAV 975
            |.||.|...|.              ..|:|..|.         |.|.|..    .:::..|...:
Human  2427 LGDELERRPYTGNPQYTYNNWSPPVQSNETSNGY---------FLERSHS----ARMTLAKACEL 2478

  Fly   976 CKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQLAENEFLIPVAHFSKELYNSFGIPFLT 1040
            |.:::...|.::..|             :||....|.|.|.:|...|....:....:|.|..:..
Human  2479 CPEEVKKATSVQQIE-------------MEESKEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQ 2530

  Fly  1041 KAR-QGEPY-GALKQRIQRRLNVQDKEWENYK 1070
            ... .|:|| |.....:........:..|||:
Human  2531 NNHVHGQPYTGPAAHHMNNPQRTGQRAQENYE 2562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	227/1072 (21%)
USP9X	NP_001397677.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..65
		Ubl1_cv_Nsp3_N-like	<905..969	CDD:475130
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1004
		peptidase_C19C	1560..1963	CDD:239124	111/407 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1626		3/28 (11%)
		DUF3517	2102..2481	CDD:463438	75/409 (18%)