Protein Alignment Usp7 and Usp47

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_001390423.1
• Gene: Usp47 / 74996
• MGIID: 1922246
• Length: 1396
• Species: Mus musculus
• Alignment Length: 1257
• Identity: 277/1257 - (22%)
• Similarity: 455/1257 - (36%)
• Gaps: 384/1257 - (30%)

  Fly   130 WRIMVIPNDRALGFFLQCNGENDSP--------TWSCNAIAELRLKCHKPDAQPFTRARIKHLFY 186
            ||......|.....|||.....:.|        |.:...::| |:..:.|.:.|     ::.||.
Mouse    17 WRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSE-RITLNLPASTP-----VRKLFE 75

  Fly   187 SKENDYGY---------SNFITWQEL----------------KDSEKSYVH-------------- 212
            ...|..||         .|.:|..::                :..:|:::|
Mouse    76 DVANKVGYINGTFDLTRENGVTTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLE 140

  Fly   213 -NNSITLEVH--VVADAPH------------------GVLWDSKKHTGYVGLKNQGATCYMNSLL 256
             :|::...||  .:...|.                  .:|  :|..||||||.||..|||:||||
Mouse   141 DSNNVDDSVHDRFIGPLPREGSVASTNDYVSQNYSYSSIL--NKSETGYVGLVNQAMTCYLNSLL 203

  Fly   257 QTLYFTNSLRLSVYRIPTEADDSSK----SVGLSLQRVFHELQFG-DRPVGTKKLTKSFGWETLD 316
            |||:.|...|.::|:  .|.:||.:    |:...|||:|..||.. .|.:.|..:|:||||::.:
Mouse   204 QTLFMTPEFRNALYK--WEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSE 266

  Fly   317 SFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNI 381
            ::.||||||..||:.|.||.|.|.|.....|..|::||:..|::|....|...|.:|:.||.|.|
Mouse   267 AWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVI 331

  Fly   382 KDK------KNIYESFQDYVAPETLEGDNKY---------DAGVHGLQEASKGVIFTSFPPVLHL 431
            :..      .::.|:...::.||.|:|.|:|         |        |.||:.|..||.:|.|
Mouse   332 RPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCD--------ARKGLRFLHFPYLLTL 388

  Fly   432 HLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL-----------------AESENT--------- 470
            .|.||.:|..|...||.|||..|.|.:::..::                 ||:|.:
Mouse   389 QLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSND 453

  Fly   471 -------------------------------LAD-------------------YVLHAVLVHSGD 485
                                           :|:                   |.|.:|:||||.
Mouse   454 FSTDDAVDEGICLESSSGSEKISKPGLEKVEMAETDQRKDPIQFQLGEPNSLMYELFSVMVHSGS 518

  Fly   486 NHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFH----AKCSNAYMLVYI 546
            ..||||...|...:|.:|:.|:|..||.. .||.|::.:||......::    |..:|||||:|
Mouse   519 AAGGHYYACIKSFSDDQWYSFNDQHVSRI-TQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIY- 581

  Fly   547 RQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERG-EANT-------YVSVHVILEENFE 603
            |..:..|....:...|....:...:..|:.:|...:::|. |.||       ...|..::.||..
Mouse   582 RLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKL 646

  Fly   604 EQHK-----------RRLFDLEKVHP----RVFRIKQNQTVDELVDLFVRGF-GVSRQRMRMWNL 652
            |.||           .::.|||.|.|    |:.:      .||..|...|.: |.....|   .|
Mouse   647 EVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVK------YDEFHDYLERSYEGEEDTPM---GL 702

  Fly   653 CTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPR 717
            .....:....||.:.| :|..:||..|.||..:.:::...|:         |.|::
Mouse   703 LLGGVKSTYMFDLLLE-TRKPDQIFQSYKPGEVMVKVHVVDL---------KAETV--------- 748

  Fly   718 NKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDH 782
                      ..|.|.|                        .|.::.:....:.|..|..:|.|.
Mouse   749 ----------AAPVTVR------------------------AYLNQTVTEFKQLISKATHLPADS 779

  Fly   783 LQGHILIFERENVDAKL------DLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFT----LELSNR 837
            ::   ::.||...|.:|      .|...|.:..:.|:    :.|.:...::..||    .:|.:|
Mouse   780 MR---IVLERCYNDLRLLSMPSKTLKAEGFFRSNKVF----VESSETVDHQAAFTDSHLWKLLDR 837

  Fly   838 YNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTK----------- 891
            :     ||.:...:....|....:.....|::..|::      |.:.|.....|
Mouse   838 H-----ANTIRLFVLLPEQSPGSYSKRTAYQKAGGDS------GNVDDDCERVKGPAGNLKSVDA 891

  Fly   892 --QSSTKRIFYQRLSLSIHELDNKKQFKCVWV--------------SSDLKDEKELVLYPNKNDT 940
              :.||:::....|.....:.||....|....              ||...|.:||..:...:|.
Mouse   892 ILEESTEKLKSLSLQQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDP 956

  Fly   941 VKGLLEEAAKKISFAENSRRKLRL---LKISNHKIVAVCKDD---IPLDTLLKSNESITTA---- 995
            .....||  :..|...|.|....:   :..|:|....:|..|   |||...|.|: |||::
Mouse   957 ENFQSEE--RSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSH-SITSSRRTK 1018

  Fly   996 --QGAQKTF-RIEEVPAEDMQLAEN-------EFLIPVAHFSKELYNSFGIPFLTKARQGEPYGA 1050
              :|.::|: ..||....|.:..|:       :::    :|..:       |:......||.:..
Mouse  1019 ANEGKKETWDTAEEDSGTDSEYDESGKSRGDMQYM----YFKAD-------PYTADEGSGEGHKW 1072

  Fly  1051 LKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDNTPVDLEVYRSWTSGQ----------LPFFG 1105
            |...:.:|:.:...:.....|..:...|           .:|:|.:||.|          |..|.
Mouse  1073 LMVHVDKRITLAAFKQHLEPFVGVLSSH-----------FKVFRVYTSNQEFETVRLNETLSSFS 1126

  Fly  1106 LDHINKSRKRSSLNFSEKAIKI 1127
            .|:....|...:|...|..:|:
Mouse  1127 DDNKITIRLGRALKKGEYRVKV 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	274/1247 (22%)
Usp47	NP_001390423.1	peptidase_C19C	186..586	CDD:239124	127/411 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	426..452		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..883		5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	900..991		17/92 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1005..1045		11/40 (28%)
		USP47_C	1145..1384	CDD:466158	1/4 (25%)