DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp7 and USP28

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001333181.1	Gene:	USP28 / 57646	HGNCID:	12625	Length:	1139	Species:	Homo sapiens

Alignment Length:	1160	Identity:	210/1160 - (18%)
Similarity:	341/1160 - (29%)	Gaps:	495/1160 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DSKKHTGY-VGLKNQGATCYMNSLLQTLYFTNSLRLSV--YRIPTEADDSSKS--------VGLS 286
            |.::..|: |||||.|.||:.::::|:|:.....|..|  |.:|....::.:|        ....
Human   153 DWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQE 217

  Fly   287 LQRVFHELQFGDR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMK-------- 339
            ||.:|..:...:|    |.....|.|  |........|.||.||...|||.||...:
Human   218 LQYLFALMMGSNRKFVDPSAALDLLK--GAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSP 280

  Fly   340 -------------GTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESF 391
                         ||.|   ..|:.|||..    |.|        |||....|.:...:|:.|..
Human   281 RNKSENPMVQLFYGTFL---TEGVREGKPF----CNN--------ETFGQYPLQVNGYRNLDECL 330

  Fly   392 QDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYE 456
            :..:    :|||.:.....|.::...:. .||..||||...|.||:::.......|.:::.||.:
Human   331 EGAM----VEGDVELLPSDHSVKYGQER-WFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQ 390

  Fly   457 HINLDRYL--------------------------------------------------------- 464
            .|.:|||:
Human   391 IIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTK 455

  Fly   465 ----------------------------------------------------------------- 464

Human   456 PASESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSRS 520

  Fly   465 -----------------------------AESENTLAD-------------------------YV 475
                                         :|.|..:.|                         |.
Human   521 SMEMPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYR 585

  Fly   476 LHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNA 540
            |||||||.|..:.|||..:|..:....|.|::|..|:....:|....:|||:        :..:|
Human   586 LHAVLVHEGQANAGHYWAYIYNQPRQSWLKYNDISVTESSWEEVERDSYGGL--------RNVSA 642

  Fly   541 YMLVYIRQSELDRVLGDI--TESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEEN-- 601
            |.|:|| ..:|.....:.  |||:..|: ||.|.:|.:                  |.|.|:|
Human   643 YCLMYI-NDKLPYFNAEAAPTESDQMSE-VEALSVELK------------------HYIQEDNWR 687

  Fly   602 -------FEEQHKRRLFDLE---KVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQ 656
                   :||:...::..:|   ....:.:...|..:|            .|...:|    |.:.
Human   688 FEQEVEEWEEEQSCKIPQMESSTNSSSQDYSTSQEPSV------------ASSHGVR----CLSS 736

  Fly   657 TQKFSHFDFVAEGSRTIEQISTSQKPWV---IWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRN 718
                .|...|.|  :|.:.|:.:.:.:.   :...|:......|..|...:|.    |.....:.
Human   737 ----EHAVIVKE--QTAQAIANTARAYEKSGVEAALSELKEAEPKKPMPQETN----LAEQSEQP 791

  Fly   719 KRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHL 783
            .:.|....|.||::......:|.|...|   ..::...||              |..:..|.  :
Human   792 PKANDAESTAQPNSEVSEVEIPSVGRIL---VRSDADGYD--------------EEVMLSPA--M 837

  Fly   784 QGHIL-------IFERENVDAKLDLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYD 841
            ||.||       .|:|:..:|.|               |:.            |..|.|..|
Human   838 QGVILAIAKARQTFDRDGSEAGL---------------IKA------------FHEEYSRLY--- 872

  Fly   842 QLANAVAERLNTDPQKLQ-----FFMCINNYKETAGNAVPYTFKGTIKDLVSYT--KQSSTKRIF 899
            |||...... ::|| :||     ||.          |..|       |.:|..|  :|.:.|.:.
Human   873 QLAKETPTS-HSDP-RLQHVLVYFFQ----------NEAP-------KRVVERTLLEQFADKNLS 918

  Fly   900 YQRLSLSIHELDNKKQFKCVWVSSDLKDEKE---------------------LVLYPNKNDTVKG 943
            |...|:||.::   .|.|...:..|..:.:|                     |.||.      ||
Human   919 YDERSISIMKV---AQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQ------KG 974

  Fly   944 LLEEAAKKISFAENS---------RRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQ 999
            ..:||...:.:|..|         ||.::...|:.::...:.:.:....:|.::|:..:..:|..
Human   975 KYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAASLFETNDDHSVTEGIN 1039

  Fly  1000 KTFRIEEVPAEDMQLAENEFLIPVAH------FSKELYNSFGIPFLTKARQGEPYGALKQRIQRR 1058
                           ..||.:||..|      .||:..::
Human  1040 ---------------VMNELIIPCIHLIINNDISKDDLDA------------------------- 1064

  Fly  1059 LNVQDKEW---------ENYKFC--------------VISMGHNADVNDNTPVDL 1090
            :.|....|         ||.:.|              :|.:.....:..|:|.||
Human  1065 IEVMRNHWCSYLGQDIAENLQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDL 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	210/1160 (18%)
		peptidase_C19C	239..549	CDD:239124	98/521 (19%)
		USP7_ICP0_bdg	647..886	CDD:289221	48/253 (19%)
		USP7_C2	897..1113	CDD:291217	40/253 (16%)
USP28	NP_001333181.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900