DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and usp9

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_005167793.1	Gene:	usp9 / 568683	ZFINID:	ZDB-GENE-061019-1	Length:	2594	Species:	Danio rerio

Alignment Length:	480	Identity:	126/480 - (26%)
Similarity:	200/480 - (41%)	Gaps:	126/480 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   239 GYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIP------------TEADDSSKSVGLSLQRVF 291
            |:|||||.||||||||::|.||....:|..:..|.            .|..|:..:|....:...
Zfish  1554 GFVGLKNAGATCYMNSVIQQLYMIPPIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDEVFG 1618

  Fly   292 HELQFGDRP------------VGT-KKLTKSFG---------------------W-ETLDSFMQH 321
            ::.||.|:|            :|. ::|...||                     | |.::...||
Zfish  1619 YQHQFDDKPSLSKSEDRKEYNIGVLRQLQVIFGHLASSRLQYYVPRGFWKQFRLWGEPVNLREQH 1683

  Fly   322 DVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKN 386
            |..||...|:|.|:..:|.......:..:..|..:....|:...:.....|:|..:.::|::.:|
Zfish  1684 DALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQN 1748

  Fly   387 IYESFQDYVAPETLEGDNKYDAGVHGLQEASKGV------IFTSFPPVLHLHLMRFQYDPVTDSS 445
            :.:|.:.||..:.|||.|.|..     ::.:|.|      :....||||.:.|.||.||...:.:
Zfish  1749 LLDSMEQYVKGDLLEGANAYHC-----EKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECA 1808

  Fly   446 IKYNDRFEFYEHINLDRY----LAESENT-----------------------LADYVLHAVLVHS 483
            ||:||.|||...::::.|    :|:.|.:                       .:.|.|..|||||
Zfish  1809 IKFNDYFEFPRELDMEPYTVAGVAKLEGSDVHPENQQQVIQQNEPSEPEPPCSSRYRLVGVLVHS 1873

  Fly   484 GDNHGGHYVVFINPK----ADG---RWFKFDDDVVSSCR---KQEAIEQNYGG---------MDD 529
            |...||||..:|..:    .:|   ||:||||..|:.|:   .:|...|.:||         |..
Zfish  1874 GQASGGHYYSYIIQRNGSGGEGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMK 1938

  Fly   530 EISF--HAKCSNAYMLVYIRQSELDR---VLGDITESEISSDLVERLDLEKRIEMARRKERGEAN 589
            .:|:  ..:..|||:|.|.|...||:   ::..|||..:||. ..::.:...||.:.||
Zfish  1939 RMSYRRQKRWWNAYILFYERMDTLDKDSELVKYITELTVSSK-PHQVKMPSAIERSVRK------ 1996

  Fly   590 TYVSVHVILEENFEEQHKRRLFDLE 614
                      :|.:..|.|..:.||
Zfish  1997 ----------QNVQFMHNRMQYSLE 2011

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	126/480 (26%)
		peptidase_C19C	239..549	CDD:239124	110/410 (27%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
usp9	XP_005167793.1	peptidase_C19C	1554..1961	CDD:239124	110/411 (27%)
usp9	XP_005167793.1	UCH	1556..1956	CDD:278850	107/404 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910