DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and usp28

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_001920096.1	Gene:	usp28 / 567050	ZFINID:	ZDB-GENE-041008-142	Length:	1163	Species:	Danio rerio

Alignment Length:	1385	Identity:	251/1385 - (18%)
Similarity:	418/1385 - (30%)	Gaps:	561/1385 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IETDQSIEAMDTQDTQEVEILTSDLQQTQQQRNSPPQLPKFKNLIQPQL-HAVGAVTQLPSENGN 66
            :..:|..|..:|.:.....:|....:.|..|  .|..|....|..|..: ||:|.:|..|.|..:
Zfish     1 MRVEQEFEHGETSENSSQMLLNQLREITGIQ--DPQVLQSALNAGQGDISHAIGLLTTQPPEEEH 63

  Fly    67 MPPQQLLA--DSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVYVRMLP 129
            ||.|...|  :.:::|..:|.|       |:|   .:|....:::...|.:::|
Zfish    64 MPEQTTTANNEKNTSSAQNGPA-------KDD---LQTAIELSLQESQQAEAER----------- 107

  Fly   130 WRIMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGY 194
                     |.|...|:.:.|.::                         ||||.
Zfish   108 ---------RELHRALEVSAEENA-------------------------ARIKR----------- 127

  Fly   195 SNFITWQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTL 259
                  :..:.|.:|......|..|     |.|             ||::|.|.||:.::::|:|
Zfish   128 ------KRCEGSGESCSPAEWIRQE-----DCP-------------VGIRNVGNTCWFSAVIQSL 168

  Fly   260 YFTNSLRLSVY------RIPTEADDSSKSVGLSLQR---------VFHELQFGDRPVGTKKLTKS 309
            :.....|..|.      |:..:....|:...::..:         |....:|.|.....:.|..:
Zfish   169 FHLPVFRRLVLNYCLSERVLEKCKSHSEKRNIAFMQELRCLFALMVGSNRRFVDPSAAVELLRDA 233

  Fly   310 FGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETF 374
            |    ..|..|.||.||...|||.||...: ....||.|   |.|       :|.......|.||
Zfish   234 F----RTSEAQQDVSEFTHKLLDWLEDAFQ-LAANGTNP---EDK-------QNNPMVQLFYGTF 283

  Fly   375 YDIQLNIKDKKNIYESFQDYVAPETLEGDNKYD------------AGVHGLQEASKGV--IFTSF 425
            ...:|:..:..:..|.|..|  |..:.|.|..|            ..:|..|..|.|.  .|:..
Zfish   284 VAERLHEGEIVSNIEQFGQY--PLQVNGFNNLDECLEGAMVEGEIESLHSDQTLSSGQERWFSKL 346

  Fly   426 PPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL-------------------------- 464
            ||||...|.||:::.......|.:.:.||.:.|.:||||
Zfish   347 PPVLTFELSRFEFNQSLGRPEKIHKKLEFPQVIYMDRYLHKNVNQTHGRRGEVKRLKDQLTLLQQ 411

  Fly   465 ----------------------------------------------------------------- 464

Zfish   412 KLEGYKNYGSGPAKYPLADMLQYVLEFATTKPTNPGSPVPTNPPISTDPSSGDSSQTEADDAGSS 476

  Fly   465 -----------------------------------------------------AESENTLAD--- 473
                                                                 ||.|||:::
Zfish   477 DGSGCPPTATQRTPIHKPFTQCRPPMEVPVQPAPHSVSEEELHFIRSCLQRWRAEVENTISELKA 541

  Fly   474 ----------------------YVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRK 516
                                  |.|||||||.|....|||..:|...|..||.|::|.:|:....
Zfish   542 SIDKVSQALEGMYSDNSLCQVPYRLHAVLVHEGQASAGHYWAYIYDHAQRRWLKYNDVLVAESTW 606

  Fly   517 QEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMAR 581
            :|.:..:||||.:        ::||.|:||..: |..::.:.|:.| :..:::.:|
Zfish   607 EELVRDSYGGMTN--------ASAYCLMYINDN-LPYLIAEDTDVE-TGQVLKGMD--------- 652

  Fly   582 RKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQR 646
                       |:..:|.....|.:                               |.|   :|.
Zfish   653 -----------SLPSVLRRYVREDN-------------------------------RWF---QQE 672

  Fly   647 MRMW--NLCTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLL 709
            :|.|  ..|.||..:            |..|.:||..          |:.|.|..|.||:.|
Zfish   673 LREWEEQFCQAQRDE------------TPVQTNTSTS----------TEQPVPEEPQNPEPE--- 712

  Fly   710 FLKYYDPRNKRLNY-------------IGCTQQPHTRRLIDLVPDVN--------SKLGFEPDTE 753
                  |..::.|.             :..:::|....|..:.|:.:        |:...:|:.|
Zfish   713 ------PTQEQTNEDTEEPPSDSTPAPVQESEEPTVSPLNPISPEASENEEQINGSQTQDQPEEE 771

  Fly   754 LTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEII 818
            .....:......:.....:|..:..|:...:.        .|||:.|
Zfish   772 KPDQSQSVSAGELETETEVEEQVTNPEGGAEA--------EVDAQTD------------------ 810

  Fly   819 FSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQ------------KLQFFMCINNYKETA 871
                   .|...|.|            :.||..||.|:            |:.....::.|.|..
Zfish   811 -------PEASSTEE------------STAEDTNTQPENEVSEVEIPNVGKILVRSDVDGYNEEM 856

  Fly   872 GNAVPYTFKGTI----KDLVSYTK---QSSTKRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEK 929
              .:....:|.|    |...::.|   ::...:.|::.. |.::||..::    .....|.:.:.
Zfish   857 --MLTPAMQGVIFAIAKAREAFDKDGPEAGLIKAFHEEY-LRLYELSQEE----TTPQQDPRLQH 914

  Fly   930 ELV-LYPNK---NDTVKGLLEEAA--------KKISFAENSRRKLRLLKISNHKIVAVCKDDIPL 982
            .|| |:.||   ....:.|||:..        :.:|....:|.||||::          .:|:.:
Zfish   915 VLVYLFQNKAPERVIERTLLEQFGDRNLSFDDRAVSIMREARSKLRLIR----------PEDMDM 969

  Fly   983 DTLLKSNESITTAQGAQKTFRIEEVPAEDMQLAE-NEFLIPVAHFSKELYNSFGIPFLTKARQGE 1046
            |..|:.::..:.   .:..|.......|..|..: .|.||.:||..::  ||   ..|||   ||
Zfish   970 DEYLQWHDDYSM---FKTVFAYLLTGLEQYQNGKIREALIYLAHAHQD--NS---ALLTK---GE 1023

  Fly  1047 PYGA-------LKQRIQRRLN--------VQDK----EWEN-YKFCVISMGHNADVNDNTPVDLE 1091
            ..|.       .:::..:.||        .||:    |.|: ...|||...|....:..:..||:
Zfish  1024 RKGVDQSLIALYRRKCLKELNEKAATLFKSQDESDVTEGESLMNECVIPCMHLMVRDSVSQEDLD 1088

  Fly  1092 VY----RSWTSGQLPFFGLD 1107
            |.    ..|.|    :.|.|
Zfish  1089 VIELIRNCWCS----YLGQD 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	17/128 (13%)
		COG5077	101..1119	CDD:227409	226/1284 (18%)
		peptidase_C19C	239..549	CDD:239124	99/507 (20%)
		USP7_ICP0_bdg	647..886	CDD:289221	44/277 (16%)
		USP7_C2	897..1113	CDD:291217	55/248 (22%)
usp28	XP_001920096.1	UBA_UBP25_like	19..55	CDD:270462	10/37 (27%)
		UCH	149..>393	CDD:278850	66/273 (24%)
		Peptidase_C19I	151..628	CDD:239130	96/501 (19%)
		Peptidase_C19	151..>254	CDD:271592	25/106 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900