DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and usp7

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_009297739.2	Gene:	usp7 / 553758	ZFINID:	ZDB-GENE-030131-3656	Length:	1130	Species:	Danio rerio

Alignment Length:	1128	Identity:	541/1128 - (47%)
Similarity:	746/1128 - (66%)	Gaps:	82/1128 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NSPPQLPKFKNLIQPQLHAVGAVTQLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFR 99
            :.||::|                 |.|..|||:    .:||..:.:..|.|    ||.|    :|
Zfish    52 DDPPRIP-----------------QNPVINGNV----AMADGHNNTEEDME----DDTS----WR 87

  Fly   100 SETTFSFTVENVVQLKSQRLSPPVYVRMLPWRIMVI-------PNDRALGFFLQCNGENDSPTWS 157
            ||.||.|.||...:|....||||.:||.|||:|||:       |:.:::|||||||.|:||.:||
Zfish    88 SEATFPFVVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWS 152

  Fly   158 CNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHV 222
            |:|.|.|::..:|.|.:.|:| ||.|||:.||||:|:|||::|.::.|.|:.:|.::.:|.||:|
Zfish   153 CHAQAMLKIINYKDDEKSFSR-RISHLFFHKENDWGFSNFMSWSDVTDPERGFVEDDKVTFEVYV 216

  Fly   223 VADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSL 287
            .|||||||.||||||||||||||||||||||||||||:|||.||.:||.:|||.|||||||.|:|
Zfish   217 QADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRRAVYMMPTEGDDSSKSVPLAL 281

  Fly   288 QRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFE 352
            ||||:|||..|:||||||||||||||||||||||||||..|||||.:|:|||||.:|||||.||.
Zfish   282 QRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFR 346

  Fly   353 GKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQEAS 417
            |||.|||:||:|||.|.|.|.:|||||:||.||||:|||:||||.|.|:||||||||.||||||.
Zfish   347 GKMVSYIQCKHVDYRSERIEDYYDIQLSIKGKKNIFESFKDYVAVEQLDGDNKYDAGEHGLQEAE 411

  Fly   418 KGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESE-NTLADYVLHAVLV 481
            |||.|.:|||:|||.||||.|||.||.:||.||||||.|.:.||.:|.:.: ...|:|:||||||
Zfish   412 KGVKFLTFPPILHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKPDVKDPANYILHAVLV 476

  Fly   482 HSGDNHGGHYVVFINPKADGR-------WFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSN 539
            ||||||||||||::|||.||:       |.||||||||.|.|:||.|.||||.||::|.. .|:|
Zfish   477 HSGDNHGGHYVVYLNPKGDGKVSVTAPIWCKFDDDVVSRCTKEEATEHNYGGHDDDLSVR-HCTN 540

  Fly   540 AYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEE 604
            ||||||||:|:|..||..:|:.:|...|||||..|||:|..:||||.||:.|:.|.::.|:.|..
Zfish   541 AYMLVYIRESKLSEVLQPVTDMDIPQQLVERLQEEKRVEAQKRKERQEAHLYMQVQMVTEDQFCG 605

  Fly   605 QHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQ--TQKFSHFDFVA 667
            .....::|.|||...||::.::.|:.|.|....:..|..:.:||:|.:....  |::.:..|:.|
Zfish   606 HQGNDMYDEEKVKYTVFKVLKSSTLAEFVQNLSQTMGFPQDQMRLWPMQARSNGTKRPAMLDYEA 670

  Fly   668 EGSRTIEQISTSQKPWVIWLQLAWTDVP---GPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQ 729
            :.::::..:|.::.||.|:|:....::.   ..||.|:...:.:||||.|||:.:.|||.|....
Zfish   671 DCNKSMIDLSDNENPWTIFLETVDPEMAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYT 735

  Fly   730 PHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPI-------ESALFIPQDHLQGHI 787
            |.:.::.||:|.:..:.||:..|.|.:|:|...    ||.|.|       :.||   .:.:.|.|
Zfish   736 PISCKIRDLLPVMCERAGFQQGTSLILYEEVKP----NLTERIQDYDVSLDKAL---DELMDGDI 793

  Fly   788 LIFERENVDAKL-DLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYDQLANAVAERL 851
            ::|::::.:... :|||..|||.||.:|:::||.||...|:|.|.:.||||.||.|:|..||:||
Zfish   794 IVFQKDDPENDTSELPTAKDYFRDLYHRVDVIFCDKTIHNDPGFVVTLSNRMNYFQVAKTVAQRL 858

  Fly   852 NTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDNKKQF 916
            ||||..||||.. ..|::..||.:.:.::||::||:.:.|....|:::||:|.:.|.:.:|::.|
Zfish   859 NTDPMLLQFFKS-QGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSF 922

  Fly   917 KCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIP 981
            |.:|::|..::| |:.|||:|:..|:.||||..|.:..::....|||||:|.::||:.|.::|..
Zfish   923 KAIWLNSMFREE-EITLYPDKHGCVRDLLEECKKAVELSDKGSEKLRLLEIVSYKIIGVHQEDEL 986

  Fly   982 LDTLLKSNESITTAQGAQKTFRIEEVPAEDMQL-AENEFLIPVAHFSKELYNSFGIPFLTKARQG 1045
            |:.|         :..|.:||||||:|.:.:.| .|||.|||||||.||::.:||||||.|.|||
Zfish   987 LECL---------SPAASRTFRIEEIPLDQVDLDKENEMLIPVAHFHKEVFGTFGIPFLLKIRQG 1042

  Fly  1046 EPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDN----TPVDLEVYRSWTSGQLPFFGL 1106
            ||:..:.:|||..|::|:||:|.:||.::.||.:..:|:.    ...|.|......|...|:.||
Zfish  1043 EPFREVMKRIQSMLDIQEKEFEKFKFAIVMMGRHQYINEEDYEVNLKDFEPQPGNMSHPRPWLGL 1107

  Fly  1107 DHINKSRKRSSLNFSEKAIKIYN 1129
            ||.||:.||....:.||||||:|
Zfish  1108 DHFNKAPKRGRYTYLEKAIKIHN 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	66/135 (49%)
		COG5077	101..1119	CDD:227409	517/1050 (49%)
		peptidase_C19C	239..549	CDD:239124	227/317 (72%)
		USP7_ICP0_bdg	647..886	CDD:289221	85/251 (34%)
		USP7_C2	897..1113	CDD:291217	89/220 (40%)
usp7	XP_009297739.2	Peptidase_C19	77..1128	CDD:321984	528/1078 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586689
Domainoid	1	1.000	453	1.000	Domainoid score	I486
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2592
Inparanoid	1	1.050	1026	1.000	Inparanoid score	I273
OMA	1	1.010	-	-		QHG55761
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	1	1.000	-	-		FOG0003101
OrthoInspector	1	1.000	-	-		oto38870
orthoMCL	1	0.900	-	-		OOG6_101317
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2325
SonicParanoid	1	1.000	-	-		X2073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800