DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and USP40

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001369225.1	Gene:	USP40 / 55230	HGNCID:	20069	Length:	1256	Species:	Homo sapiens

Alignment Length:	1175	Identity:	249/1175 - (21%)
Similarity:	390/1175 - (33%)	Gaps:	388/1175 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 ELKDSEKSYVHNNSI---------TLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQ 257
            :|.:.|.|.|.||..         .||    ..||       ::.|...|::|||.|||:|||||
Human     4 DLFEEEYSTVSNNQYGKGKKLKTKALE----PPAP-------REFTNLSGIRNQGGTCYLNSLLQ 57

  Fly   258 TLYFTNSLRLSVYRIPTEA----DDSSKS------VGLSLQRVFHELQFGDR-PVGTKKLTKSFG 311
            ||:||...|.:::.:..|.    :|..|.      :.|.|||:|.:|...|: ...|..||.|||
Human    58 TLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFG 122

  Fly   312 WETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYD 376
            |.:.:...||||||..|:|...||:.:.||.....|..|:.|.:.:.|.||.....|.|.|.|.|
Human   123 WTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLD 187

  Fly   377 IQLNIKDKKNIYESFQD-YVAPETLEGDNKYDAGV-HGLQEASKGVIFTSFPPVLHLHLMRFQYD 439
            :.:.:|:...:.::..: ||..|..:.||.|..|. ..|.:|:|.......||.|.:.|:||.:|
Human   188 LTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFD 252

  Fly   440 PVTDSSIKYNDRFEFYEHINLDRYLAESENTLADYV--LHAVLVHSGDNHGGHYVVFIN------ 496
            .|.....|....:.|...|||..:..:||....:|:  |.:|::|.|..:||||.|:|.
Human   253 FVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLG 317

  Fly   497 ----------------------------------------------------------------- 496

Human   318 NWQFQEEKSKPDVNLKDLQSEEEIDHPLMILKAILLEEENNLIPVDQLGQKLLKKIGISWNKKYR 382

  Fly   497 ----------------------------------------------------PKADG-------- 501
                                                                |::.|
Human   383 KQHGPLRKFLQLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCP 447

  Fly   502 RWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRVLGDITESE---- 562
            .||..:|..|...|::: |||.:.|.:          :||||.| |:|:|.|.    .|:.
Human   448 HWFDINDSKVQPIREKD-IEQQFQGKE----------SAYMLFY-RKSQLQRP----PEARANPR 496

  Fly   563 --ISSDLVERLDLEKRIEMARRKERGEANTYVSVHV----------------------ILEENFE 603
              :...|:..:|........:|.|...||....:|:                      :.:..|:
Human   497 YGVPCHLLNEMDAANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFD 561

  Fly   604 EQH-----KRRLFDL------------EKVHPRVFRIKQNQTVDELV----------DLFV-RGF 640
            ::.     ::.:|.|            .|:.|....|.|:...|||.          |:|| .|.
Human   562 KRKTLGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWNGV 626

  Fly   641 GVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKT 705
            .|....::....|........|.|..::|.:..:.|   :.|.|.              |.|.:.
Human   627 EVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVI---ESPHVF--------------PANAEV 674

  Fly   706 ESLLFLKYYDPRNKRLNYIGC------TQQPHTRRLIDLVPDVNS---KLGFEPDTELTIYDEYA 761
            .::|...........:|..||      |..|.        .|:..   :.|....:.:.|.|.:.
Human   675 GTVLTALAIPAGVIFINSAGCPGGEGWTAIPK--------EDMRKTFREQGLRNGSSILIQDSHD 731

  Fly   762 DKKLVNLNEP-IESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEIIFSDKCNP 825
            |..|:...|. :.|...|...|:: ::...|.|....|:. .||.....|:  ||:.|
Human   732 DNSLLTKEEKWVTSMNEIDWLHVK-NLCQLESEEKQVKIS-ATVNTMVFDI--RIKAI------- 785

  Fly   826 NEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAV--PYTFKGTIKDLV- 887
                                          ::|:..      ||.|.|:.  |....|.:...|
Human   786 ------------------------------KELKLM------KELADNSCLRPIDRNGKLLCPVP 814

  Fly   888 -SYT-KQSSTKRIFYQRLSLSIHELDNKKQ-FKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAA 949
             ||| |::..|  ....|.|.:.:..:..| |....:.||::...|:.:...:..:|:..|:...
Human   815 DSYTLKEAELK--MGSSLGLCLGKAPSSSQLFLFFAMGSDVQPGTEMEIVVEETISVRDCLKLML 877

  Fly   950 KKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQL 1014
            || |..:.....||.:.........:|:::.....|      ||...|    |..:  |.:|..|
Human   878 KK-SGLQGDAWHLRKMDWCYEAGEPLCEENSARSQL------ITLGTG----FSFQ--PCQDATL 929

  Fly  1015 AENEFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRI-QRRLNVQDKEWENYK---FCVIS 1075
                         |||....|...|....|..|.|.||..| ..:|......||:::   .|..|
Human   930 -------------KELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSS 981

  Fly  1076 MGH------NADVNDNTPV--------DLEVYRSWTSGQL--------PF--FGLD---HINK-- 1111
            .|.      :...:.|.|.        |:|:....|..:|        ||  ||:.   |:..
Human   982 WGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWT 1046

  Fly  1112 -SRKR 1115
             .|||
Human  1047 VERKR 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	10/35 (29%)
		COG5077	101..1119	CDD:227409	249/1175 (21%)
		peptidase_C19C	239..549	CDD:239124	111/455 (24%)
		USP7_ICP0_bdg	647..886	CDD:289221	41/250 (16%)
		USP7_C2	897..1113	CDD:291217	51/250 (20%)
USP40	NP_001369225.1	peptidase_C19C	39..344	CDD:239124	94/304 (31%)
USP40	NP_001369225.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D77113at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920