DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and USP47

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001317137.1	Gene:	USP47 / 55031	HGNCID:	20076	Length:	1375	Species:	Homo sapiens

Alignment Length:	1238	Identity:	280/1238 - (22%)
Similarity:	453/1238 - (36%)	Gaps:	365/1238 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 WRIMVIPNDRALGFFLQCNGENDSPTWSC-------NAIAELRLKCHKPDAQPFTRARIKHLFYS 187
            ||......|.....|||.....:.|...|       :.....|:..:.|.:.|     ::.||..
Human    17 WRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTP-----VRKLFED 76

  Fly   188 KENDYGYSN---FITW-----------------QELKDS-----EKSYVH-------NNSITLE- 219
            ..|..||.|   .:.|                 :.|.|:     :|:::|       ...|.||
Human    77 VANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLED 141

  Fly   220 -------VH--VVADAPH----GVLWD------------SKKHTGYVGLKNQGATCYMNSLLQTL 259
                   ||  .:...|.    |...|            :|..||||||.||..|||:|||||||
Human   142 SSAGEDSVHDRFIGPLPREGSGGSTSDYVSQSYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTL 206

  Fly   260 YFTNSLRLSVYRIPTE--ADDSSKSVGLSLQRVFHELQFG-DRPVGTKKLTKSFGWETLDSFMQH 321
            :.|...|.::|:...|  .:|...|:...|||:|..||.. .|.:.|..:|:||||::.:::.||
Human   207 FMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQH 271

  Fly   322 DVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDK-- 384
            ||||..||:.|.||.|.|.|.....|..|::||:..|::|....|...|.:|:.||.|.|:..
Human   272 DVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGS 336

  Fly   385 ----KNIYESFQDYVAPETLEGDNKY---------DAGVHGLQEASKGVIFTSFPPVLHLHLMRF 436
                .::.|:...::.||.|:|.|:|         |        |.||:.|..||.:|.|.|.||
Human   337 SQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCD--------ARKGLRFLHFPYLLTLQLKRF 393

  Fly   437 QYDPVTDSSIKYNDRFEFYEHINLDRYL-----------------AESE---------------- 468
            .:|..|...||.|||..|.|.:::..::                 ||:|
Human   394 DFDYTTMHRIKLNDRMTFPEELDMSTFIDVEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSNDD 458

  Fly   469 ------------------------NTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDD 509
                                    |:|. |.|.:|:||||...||||...|...:|.:|:.|:|.
Human   459 GVDEGICLETNSGTEKISKSGLEKNSLI-YELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQ 522

  Fly   510 VVSSCRKQEAIEQNYGGMDDEISFH----AKCSNAYMLVYIRQSELDRVLGDITESEISSDLVER 570
            .||.. .||.|::.:||......::    |..:|||||:| |..:..|....:...|....:...
Human   523 HVSRI-TQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIY-RLKDPARNAKFLEVDEYPEHIKNL 585

  Fly   571 LDLEKRIEMARRKERG-EANT----YVSVH---VILEENFEEQHK-----------RRLFDLEKV 616
            :..|:.:|...:::|. |.||    ...:|   .::.||..|.||           .::.|||:|
Human   586 VQKERELEEQEKRQREIERNTCKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEEV 650

  Fly   617 HP----RVFRIKQNQTVDELVDLFVRGF-GVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQI 676
            .|    |:.:      .||..|...|.: |.....|   .|.....:....||.:.| :|..:|:
Human   651 IPLDCCRLVK------YDEFHDYLERSYEGEEDTPM---GLLLGGVKSTYMFDLLLE-TRKPDQV 705

  Fly   677 STSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPD 741
            ..|.||..:.:::...|:         |.||:                   ..|.|.|
Human   706 FQSYKPGEVMVKVHVVDL---------KAESV-------------------AAPITVR------- 735

  Fly   742 VNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGD 806
                             .|.::.:....:.|..|:.:|.:.::   ::.||...|.:|...:...
Human   736 -----------------AYLNQTVTEFKQLISKAIHLPAETMR---IVLERCYNDLRLLSVSSKT 780

  Fly   807 YFLDLVYRIEIIFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMC------IN 865
            ...:..:|...:|.      |...||:....:....|...:....||    ::.|:.      ::
Human   781 LKAEGFFRSNKVFV------ESSETLDYQMAFADSHLWKLLDRHANT----IRLFVLLPEQSPVS 835

  Fly   866 NYKETA--------GNAVPYTFK-----GTIKDLVSYTKQS----------------------ST 895
            ..|.||        ||......:     |::|.:.:..::|                      ||
Human   836 YSKRTAYQKAGGDSGNVDDDCERVKGPVGSLKSVEAILEESTEKLKSLSLQQQQDGDNGDSSKST 900

  Fly   896 KRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRR 960
            :...::.:...::|.|          ||...|.:||..:...:|......||  :..|...|.|.
Human   901 ETSDFENIESPLNERD----------SSASVDNRELEQHIQTSDPENFQSEE--RSDSDVNNDRS 953

  Fly   961 KLRL---LKISNHKIVAVCKDD---IPLDTLLKSNESITTA------QGAQKTF-RIEEVPAEDM 1012
            ...:   :..|:|....:|..|   |||...|.|: |||::      :|.::|: ..||....|.
Human   954 TSSVDSDILSSSHSSDTLCNADNAQIPLANGLDSH-SITSSRRTKANEGKKETWDTAEEDSGTDS 1017

  Fly  1013 QLAEN-------EFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYK 1070
            :..|:       :::    :|..|       |:......||.:..|...:.:|:.:...:.....
Human  1018 EYDESGKSRGEMQYM----YFKAE-------PYAADEGSGEGHKWLMVHVDKRITLAAFKQHLEP 1071

  Fly  1071 FCVISMGHNADVNDNTPVDLEVYRSWTSGQ----------LPFFGLDHINKSRKRSSLNFSEKAI 1125
            |..:...|           .:|:|.:.|.|          |..|..|:....|...:|...|..:
Human  1072 FVGVLSSH-----------FKVFRVYASNQEFESVRLNETLSSFSDDNKITIRLGRALKKGEYRV 1125

  Fly  1126 KIY 1128
            |:|
Human  1126 KVY 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	28/151 (19%)
		COG5077	101..1119	CDD:227409	276/1227 (22%)
		peptidase_C19C	239..549	CDD:239124	127/388 (33%)
		USP7_ICP0_bdg	647..886	CDD:289221	41/257 (16%)
		USP7_C2	897..1113	CDD:291217	47/245 (19%)
USP47	NP_001317137.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..452		3/26 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	840..859		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..968		17/99 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	983..1024		11/41 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820