Protein Alignment Usp7 and puf

DIOPT Version :9

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_001262923.1
• Gene: puf / 42935
• FlyBaseID: FBgn0039214
• Length: 3930
• Species: Drosophila melanogaster
• Alignment Length: 1141
• Identity: 248/1141 - (21%)
• Similarity: 387/1141 - (33%)
• Gaps: 349/1141 - (30%)

  Fly    43 FKNLIQPQLHAVGAVTQLPSE--NGNMPPQQLLADSSSTSFGDG-------EAMGIDDESKEDQF 98
            ::.|:.|.||.:.|:..|..:  :||...|.||::.....:|..       .|..:|..|.|...
  Fly  1809 YRLLLAPLLHKLIALLPLAEQMSSGNQHTQFLLSEEGKDPYGPACRDYFWLLARLVDTLSPEMVA 1873

  Fly    99 RSETTFSFTVENVVQLKSQRLSPPVY------------VRMLPWRIMVIPND-------RALGFF 144
            ..........|::    ||.:....|            |.:|.....:|..|       :||.|.
  Fly  1874 EEHIDIEMLCESI----SQSILTREYYELRHGYQDDGLVGLLNLMSNLIKYDTTFKYTPKALSFI 1934

  Fly   145 LQCNG---ENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDS 206
            .|..|   :..||.      ...:.||....::......:..|......:|.|.:.....:.|..
  Fly  1935 EQLIGFLFDMPSPA------DRQKPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSG 1993

  Fly   207 EKSYVHNNSITLEVHVVADAPHGVLWD------SKKHTGYVGLKNQGATCYMNSLLQTLYFTNSL 265
            .|.                 |:.  ||      .:...|||||.|.||||||.|.:|.||.....
  Fly  1994 PKQ-----------------PYP--WDYWPRDEGRAECGYVGLTNLGATCYMASCVQHLYMMPQA 2039

  Fly   266 RLSVYRIPTEADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFG-----------WETLDSFM 319
            |.:|.|:|..|........|.|||:|..|...:|        ||:.           .:.|::..
  Fly  2040 RAAVLRVPPNAARKHGPTLLELQRMFAYLLESER--------KSYNPRSFCRVYQMDHQPLNTGE 2096

  Fly   320 QHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDK 384
            |.|:.||...|:.|||.....  |:..:..||.|.:|:.:...:..:.|...|.||.::..:.|.
  Fly  2097 QKDMAEFFIDLVSKLEDMTPD--LKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADM 2159

  Fly   385 KNIYESFQDYVAPETLEGDNKYDAGVHGLQ-EASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKY 448
            :|:.||..:....:||||||.|.....|.: .|.|...|...|.:|..:.||:.::.||....|.
  Fly  2160 RNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKV 2224

  Fly   449 NDRFEFYEHINLDRYL--------------------------------AESENTLAD-------Y 474
            |..|.|...:|:..|:                                .::|.||.|       |
  Fly  2225 NTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEY 2289

  Fly   475 VLHAVLVHSGDNHGGHYVVFINPK------ADGRWFKFDD---------DVVSSCRKQEAIEQNY 524
            .|..|.||:|...||||..||..:      ...|||.|:|         .:.:.|...|...:.|
  Fly  2290 ELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTY 2354

  Fly   525 GGMDD---EISFHAKCSNAYMLVYIRQ---------SEL-----------------DRVLGDITE 560
            ..:.:   :.||. |.::||||.|.|:         |||                 :....:.:.
  Fly  2355 DSVTEKYLDFSFE-KTNSAYMLFYERRLPEHLQRRHSELLVTPTPSPTVEEKSEAEEPTKMETSS 2418

  Fly   561 SEISSDL-----VERLDL------------------------------EKRIEMARR--KERGEA 588
            |||.:|:     ||..|.                              ||:||...|  :|:.|.
  Fly  2419 SEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSET 2483

  Fly   589 N------TYVSVHVILEE--------NFEEQHKRRLFDLEKVHP---------RVFRIKQNQTVD 630
            :      |.||..   ||        |.::.:...........|         ::||...|:.::
  Fly  2484 DEKPTEMTTVSTE---EEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLNKELE 2545

  Fly   631 ELVDLFVRGFGVSRQRMR------MWNLC-------------TAQTQKFSHFDFVAEGSRTIEQI 676
            :.:....|.|...|....      ||.:|             |....|.|...|:    .|.  |
  Fly  2546 DWIWQDNRQFLQDRNIFEHTYFNFMWQICGHIPQSLISETDVTCMAAKLSVSFFI----ETF--I 2604

  Fly   677 STSQKPWVI-WLQLAWTDVPGPLPPFNPKTESL-LFLKY--YDPRNKRLNYIGC----TQQPHTR 733
            ...:||.:: |::|.       ...||...|:. .||.:  .:|.......|.|    .:|...|
  Fly  2605 HAKEKPTMVPWVELL-------TKQFNASQEACEWFLSHMSQEPYWPVQVLIQCPNQMVRQMFQR 2662

  Fly   734 RLIDLVPDV---NSKLGFEPDTELTIYDEYADKKLV-----------NLNEPIESALFIPQDHLQ 784
            .:|.::..:   ::.|..|.:|     || .||:|:           :|...:|........||.
  Fly  2663 LVIHVIQQLRASHAHLYLEVET-----DE-DDKELIGQASCVTRFIGSLISLLEHGARANLRHLS 2721

  Fly   785 ---GHILIFERENVDAKLDLPTVG------DYFL--DLVYRIEIIFSDKCNPNEPDFTLELSNRY 838
               |.:..|.|...:..:.|..:|      |::|  .....|:|...::.|.:|...::|.....
  Fly  2722 EYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDNSSEEALSVEKMRPA 2786

  Fly   839 NYDQLANAVAE----------RLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQS 893
            :.|::....|.          ||...|:.   |..|     ..|...|:.:: .|||.::   ..
  Fly  2787 SLDKMIALCASLVERSRGADFRLRLSPKD---FSAI-----AGGKGFPFLYQ-QIKDGIN---PH 2839

  Fly   894 STKRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEK 929
            .||.:        ||.|       |.|      ||:
  Fly  2840 QTKHL--------IHAL-------CRW------DER 2854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	23/150 (15%)
		COG5077	101..1119	CDD:227409	232/1074 (22%)
		peptidase_C19C	239..549	CDD:239124	108/387 (28%)
		USP7_ICP0_bdg	647..886	CDD:289221	59/300 (20%)
		USP7_C2	897..1113	CDD:291217	7/33 (21%)
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	108/379 (28%)
		UCH	2014..2377	CDD:278850	105/373 (28%)
		DUF3517	2723..>2877	CDD:288853	33/165 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910