DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and scny

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_729092.1	Gene:	scny / 38648	FlyBaseID:	FBgn0260936	Length:	1038	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	119/572 - (20%)
Similarity:	205/572 - (35%)	Gaps:	178/572 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 MPPQQLLADSSST-------SFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRL----- 119
            ||....:.::::.       |.|...:.|    |..||.:|....:.:::|.:...::|:
  Fly     1 MPVSMAVCETANVVNAALRESLGGNSSAG----SSTDQAKSGEDTNGSLQNHIVANAKRILMAKI 61

  Fly   120 ---SPPVY----VRMLPWRIMVIP--NDRAL---------GFFLQCNGENDS--------PTWSC 158
               ..|.|    :..|..:.:||.  |..|:         |..:..||.:::        |.
  Fly    62 EYEEVPNYHESVLENLKSKYIVIKPGNPGAINGFSGKNNTGKLVGANGHDNNGARKQAEHPN--- 123

  Fly   159 NAIAELRLKCHK-PDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHV 222
            |....:....|: |.:.|....:.|.:.|.:||..     |.|   |.||:
  Fly   124 NQSHHINHHNHQHPTSNPNELPKPKRVLYPRENIR-----IGW---KQSER-------------- 166

  Fly   223 VADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSL---------------------- 265
                        |...| .|:.|.|.|||:||.||.|....:|
  Fly   167 ------------KWQVG-TGMINVGNTCYLNSTLQALLHIPALANWLVSEQAHLADCNVAEPGSG 218

  Fly   266 ----RLSVYRIPTEADDSSKSVGL---SLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDV 323
                .::...:.|:::.|:....|   .|:::...:..|                     .|.|.
  Fly   219 CIICAMTKTLLATQSNQSAVRPFLIYSKLKQICKHMVVG---------------------RQEDA 262

  Fly   324 QEFLRVLLDKLES---------KMKGTILEGTIP--GLFEGKMSSYIKCKNVDYNSTRYETFYDI 377
            .||||.|::.:|.         |....:::.|.|  .:|.|.:.|.::|.:.::.|..::.|.|:
  Fly   263 HEFLRFLVEAMERAYLMRFRNYKELDQLVKETTPLGQIFGGYLRSEVRCLSCNHVSITFQHFQDL 327

  Fly   378 QLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVT 442
            .|:|:...::.::|:.:.:.|.||.......|......|:|.......|..|.:.|.||
  Fly   328 LLDIRKADSLEDAFEGHFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRF------ 386

  Fly   443 DSSI--KYNDRFEFYEHINLDRYLAESENTLAD---YVLHAVLVHSG-DNHGGHYVVFINPKADG 501
             |.|  |...:..|...|:|.:|.|.|:...|.   |.|.:::.|.| ..|.|||.. |.....|
  Fly   387 -SMIGNKLTKQISFKSRIDLSKYAARSQAAQAQPLTYRLVSMVTHLGASQHCGHYTA-IGSTDTG 449

  Fly   502 RWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKC-SNAYMLVYIRQSELD 552
            .::.|||..|.                 .|:.|:.| :|||::.:    |||
  Fly   450 SFYNFDDSYVR-----------------PIAMHSVCNTNAYIMFF----ELD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	27/160 (17%)
		COG5077	101..1119	CDD:227409	110/531 (21%)
		peptidase_C19C	239..549	CDD:239124	80/356 (22%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
scny	NP_729092.1	Peptidase_C19E	171..477	CDD:239126	80/352 (23%)
		UCH	172..477	CDD:278850	79/350 (23%)
		Asp-B-Hydro_N	<617..>731	CDD:191249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456882
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940