DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp48

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_006239296.1	Gene:	Usp48 / 362636	RGDID:	735213	Length:	1064	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	217/919 - (23%)
Similarity:	346/919 - (37%)	Gaps:	236/919 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 WQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNS 264
            |  |.:.:::..||          .|.|:   .:.:|...:|||.|.|||||:|:.||..:....
  Rat    91 W--LGEIDENSFHN----------IDDPN---CERRKKNSFVGLTNLGATCYVNTFLQVWFLNLE 140

  Fly   265 LRLSVYRIPTEADDSSKSVGL-------------SLQRVFHELQFGDR----PVGTKKLTKSFGW 312
            ||.::|..|:...|.:|..|:             .||.:|..||..:|    |.|   ..|:.|
  Rat   141 LRQALYLCPSTCSDYTKGDGIRGGKDYEPQTICEHLQYLFALLQNSNRRYIDPSG---FVKALG- 201

  Fly   313 ETLDSFMQHDVQEFLRVLLDKLE---SKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETF 374
              ||:..|.|.|||.::.:..||   ||.|...:...:...|.|:.:....|......|.....|
  Rat   202 --LDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDVRNVVQQQFCGEYAYVTVCSQCGRESKLVSKF 264

  Fly   375 YDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDA-GVHGLQEASKGVIFTSFPPVLHLHLMRFQY 438
            |:::|||:..|.:.:...:::..|.|||||:|.. .....|.|::.:...|.|..|:|.||||.:
  Rat   265 YELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVF 329

  Fly   439 DPVTDSSIKYNDRFEFYEHINLDRYLAESENTLADYVLHAVLVHSG-DNHGGHYVVFINPKADGR 502
            |..|....|.|....|.|.::::.|:.....:.. |.|.|||:|.| ..:.|||:..:.....|.
  Rat   330 DRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSFV-YELSAVLIHRGVSAYSGHYIAHVKDPQSGD 393

  Fly   503 WFKFDDDVVSSCRKQEAIEQNYG-----GMDDEISFHAK-------------CS-NAYMLVYIRQ 548
            |:||:|         |.||:..|     |::::::..:|             || |||||||..|
  Rat   394 WYKFND---------EDIEKMEGKKLQLGIEEDLAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQ 449

  Fly   549 SE-----------LDRVLGDITESEISSDLVERLDLEKR-IEMARRKER------------GEAN 589
            ::           ..:.|.|...|:.....||..::.:: ::..|.|..            .|..
  Rat   450 TQEKNHTMVQVPAFLQELVDRDNSKFEEWCVEMAEMRRQSVDKGRAKHEEVKELYQRLPAGAEPY 514

  Fly   590 TYVSVHVI---LEENFEEQ---HKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMR 648
            .:||:..:   |:|:...:   :...|...:|:||....| ..:..:...|:|...:| ...|:.
  Rat   515 EFVSLEWLQKWLDESTPTKPIDNNACLCSHDKLHPDKISI-MKRISEYAADIFYSRYG-GGPRLT 577

  Fly   649 MWNLCTAQTQKFSHFDFVAEGSRTI---EQISTSQKP---------------WV------IWLQL 689
            :..||.         |.|.|..|.:   .|::...|.               ||      .|.||
  Rat   578 VKALCK---------DCVVERCRILRLKNQLNEDYKTVNNLLKATMKGSDGFWVGKSSLRSWRQL 633

  Fly   690 AWTDV---PGPLPPFNPKTESLLFLKYYDPRNKR-----LNY---IGCTQQPH--------TRRL 735
            |...:   .|.....|.|.....|.|......|:     ||:   |.|   ||        .|||
  Rat   634 ALEQLDEQDGEAEQSNGKINGSPFSKDESKEEKKEEEEELNFNEDILC---PHGELSISENERRL 695

  Fly   736 IDLVPDVNSKLG--FEPDTELTIYDEYADK-KLVNLNEPIESALFIPQDHLQGHILIFERENVDA 797
            :.  .:..|||.  |....|...|.|...: |::........||         |.:|...:
  Rat   696 VS--QEAWSKLQQYFPKAPEFPSYKECCSQCKILEREGEENEAL---------HKMIANEQ---- 745

  Fly   798 KLDLPTVGDYFLDLVYRIEIIFSDK---CNPNEPDFT--LELSNRYNYDQLANAVAERLNTDPQK 857
            |..||.              :|.||   |..|.|:.|  |.:.:.:..|:....|.:...:.|
  Rat   746 KTSLPN--------------LFQDKNRPCLSNWPEDTDALYIVSHFFLDEWRKFVRKPARSTP-- 794

  Fly   858 LQFFMCINNYKETAGNA--------VPYTFKGTIKD---LVSYTKQSSTKRIFYQRLSLSIHELD 911
                      ..:.|||        :.:||....|:   |::....|..:.|  |:|.:    :|
  Rat   795 ----------VSSVGNAALLCPHGGLMFTFPSLTKEDSKLIALIWPSEWQMI--QKLFV----VD 843

  Fly   912 NKKQFKCVWVSSDLKDEKELVLYPNK-NDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIV-- 973
            ...:...:.|......:.:.:..||. .|..:|||.:..:.:       |:.....|..||:|
  Rat   844 KVIKITRIEVGDVNPSQTQYISEPNLCPDCREGLLCQQQRDL-------REYTQATIYVHKVVDN 901

  Fly   974 -AVCKDDIP 981
             .|.||..|
  Rat   902 KKVMKDSAP 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	6/28 (21%)
		COG5077	101..1119	CDD:227409	217/919 (24%)
		peptidase_C19C	239..549	CDD:239124	105/350 (30%)
		USP7_ICP0_bdg	647..886	CDD:289221	61/300 (20%)
		USP7_C2	897..1113	CDD:291217	20/89 (22%)
Usp48	XP_006239296.1	UCH	117..446	CDD:278850	103/344 (30%)
		Peptidase_C19L	118..447	CDD:239133	103/344 (30%)
		DUSP	512..582	CDD:283896	14/71 (20%)
		USP48_C	958..1064	CDD:176390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820