DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp24

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_006503239.1	Gene:	Usp24 / 329908	MGIID:	1919936	Length:	2637	Species:	Mus musculus

Alignment Length:	978	Identity:	209/978 - (21%)
Similarity:	354/978 - (36%)	Gaps:	293/978 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFG 297
            ||:..:|:|||:|.|||||||::.|.||....|..|:..:..:.|:...||...:|.:|..|...
Mouse  1698 DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMES 1762

  Fly   298 DR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSY 358
            ..    |....|:.|.:..| |....|.|..||...|:|:::..:|....|......|:|..|..
Mouse  1763 KLQYYVPENFWKIFKMWNKE-LYVREQQDAYEFFTSLIDQMDEYLKKMGREQIFKNTFQGIYSDQ 1826

  Fly   359 IKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQE---ASKGV 420
            ..||:..:...|.|.|..:.|.:...:::..|...:|..|.|||.|.|..  ...:|   ..|..
Mouse  1827 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYC--EKCKEKRITVKRT 1889

  Fly   421 IFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRY---------------------- 463
            ...|.|.||.:|||||.:|..:..||||:::..|...:|::.|
Mouse  1890 CIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVAGMARQDSSSEVGENGRNMD 1954

  Fly   464 ----------LAESENTLADYVLHAVLVHSGDNHGGHYVVFINPK---ADGRWFKFDDDVVSSC- 514
                      :|.:||    |.|..|:||||..|.|||..||..:   ..|:|:||:|.|:...
Mouse  1955 QGGGGSPRKKVALTEN----YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFD 2015

  Fly   515 RKQEAIE-QNYGG-----MDDEIS----FHAKCSNAYMLVY-------------------IRQSE 550
            ...|.:| :.:||     :.|:.:    ...:..|||||.|                   :||..
Mouse  2016 LNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEA 2080

  Fly   551 LDRVLGDITESEISSDLV--------ERLD-LEKRIEMARRK----ERGEANTYVSVHVILEENF 602
            .|..|...:..|||....        :||. |.|.::...:|    |:..|..|   .::.:||.
Mouse  2081 EDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIY---QMVRDENL 2142

  Fly   603 EEQHKRRLFDLE------------------KVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRM 649
            :....|.::..:                  ..:|.:.::.....:..|...::|    :::::|:
Mouse  2143 KFMKNRDVYSSDYFSFVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLR----TKKKLRV 2203

  Fly   650 ----WNLCTAQTQKFSHFD--------FVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFN 702
                | :.|.:.......|        |::...|.:.:        |..|:.:..:|...:....
Mouse  2204 DTEEW-IATIEALLSKSLDACQWLVEYFISSEGRELVK--------VFLLECSVREVRVAVATIL 2259

  Fly   703 PKT-ESLLFLKYYDPRNKRLNYI-----------------GCTQQ-------------------- 729
            .|| :|.||   |..:.|.|:.:                 .|.|.
Mouse  2260 EKTLDSALF---YQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFSLFNTFVQKQGIRAGDLLL 2321

  Fly   730 PHT--RRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHIL--IF 790
            .|:  |.:|..:..|:.:     ::::..:.....::..||:..:...:.......|.::.  ||
Mouse  2322 RHSALRHMISFLLGVSRQ-----NSQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPGIF 2381

  Fly   791 ER----------------ENVDAKLDLPTVGDYFLDLVYRIE------------IIFSDKCNPNE 827
            ::                |.|:|.|.|.....|.|::::.:.            :::...||.:.
Mouse  2382 KQRPPISVAPSSPLLPLHEEVEALLFLSEGKPYLLEVMFALRELTGSLLALMEMVVYCCFCNEHF 2446

  Fly   828 PDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGT---------I 883
             .||:                         |.|   |.|..||   |.|:..|.|         |
Mouse  2447 -SFTM-------------------------LHF---IKNQLET---APPHELKNTFQLLHEVLVI 2479

  Fly   884 KDLVSYTKQSSTKRIFYQR---LSLSIH--ELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKG 943
            :|.:...:   .|.:|...   |:|..|  .:|:.:.::||         |.||....|....|.
Mouse  2480 EDPIQVER---VKFVFETENGLLALMHHSNHVDSSRCYQCV---------KFLVTLAQKCPAAKE 2532

  Fly   944 LLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVP 1008
            ..:|.:...|:|....:|    |:|.|....            :||.|..|:.|  |||: ..:.
Mouse  2533 YFKENSHHWSWAVQWLQK----KMSEHYWTP------------QSNVSNETSTG--KTFQ-RTIS 2578

  Fly  1009 AED 1011
            |:|
Mouse  2579 AQD 2581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	209/978 (21%)
		peptidase_C19C	239..549	CDD:239124	106/381 (28%)
		USP7_ICP0_bdg	647..886	CDD:289221	50/329 (15%)
		USP7_C2	897..1113	CDD:291217	29/120 (24%)
Usp24	XP_006503239.1	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	972..1050	CDD:340585
		peptidase_C19C	1704..2061	CDD:239124	105/363 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810