DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and usp24

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_005170208.1	Gene:	usp24 / 325631	ZFINID:	ZDB-GENE-030131-4356	Length:	2621	Species:	Danio rerio

Alignment Length:	983	Identity:	212/983 - (21%)
Similarity:	342/983 - (34%)	Gaps:	305/983 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFG 297
            ||:..:|:|||||.|||||||::.|.||....|...|..|..:.::..:||...:|.:|..|...
Zfish  1685 DSRSISGFVGLKNGGATCYMNAVFQQLYMQPGLPEGVLSIEDDTENPEESVFCQVQSLFGHLMES 1749

  Fly   298 DR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSY 358
            ..    |....|:.|.:..| |....|.|..||...|:|:|:..:|....|......|:|..|..
Zfish  1750 KLQYYVPENFWKIFKMWNKE-LYVREQQDAYEFFTSLVDQLDEHLKKIGREQIFKNTFQGIFSDQ 1813

  Fly   359 IKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDA-GVHGLQEASKGVIF 422
            ..||:..:...|.|||..:.|.:...:::..|...:|..|.|:|.|.|.. .....:...|....
Zfish  1814 KICKDCPHRYEREETFMALNLGVTSCQSLEISLDQFVRGEVLDGSNAYYCEKCKEKRTTVKRTCI 1878

  Fly   423 TSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAES---ENTLAD----------- 473
            .|.|.||.:|||||.:|..:..||||:::..|...:|::.|....   :::.||
Zfish  1879 KSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWVLNMEPYTVSGMARQDSSADHGENGRGGEAG 1943

  Fly   474 --------------YVLHAVLVHSGDNHGGHYVVFINPK---ADGRWFKFDDDVVSSC-RKQEAI 520
                          |.|..|:||||..|.|||..||..:   |.|||:||:|:||... ...|.:
Zfish  1944 SGGSPRKKVTISENYELVGVVVHSGQAHAGHYYSFIKDRRGSARGRWYKFNDNVVEEFDMNDETL 2008

  Fly   521 E-QNYGG-----MDDEIS----FHAKCSNAYMLVY-------------------IRQSELDRVLG 556
            | :.:||     :.|:.:    ...:..|||||.|                   :||...|..|.
Zfish  2009 EYECFGGEYRPKVYDQSNPYPDVRRRYWNAYMLFYQRISDQNSPVLPKKSRVSIMRQEAEDLSLS 2073

  Fly   557 DITESEI---SSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHP 618
            ..:..||   ||....|.:.::...:.|..::||                   |:.|| :||:..
Zfish  2074 APSSPEISPQSSPRPPRANNDRLTLLTRLVKKGE-------------------KKGLF-VEKMPA 2118

  Fly   619 RVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQ--KFSHFDFVAEGS----------- 670
            |:|::.:::.:.     |::...|.......:.|..|...  |..|..:.|...
Zfish  2119 RIFQMVRDENLK-----FMKNRDVYNSDYFSFTLSLASVNATKLKHASYQAMAKTSLQLAVQFLL 2178

  Fly   671 ----RTIEQISTSQKPWVI--------------W------------------------------- 686
                ||.:::....:.|:.              |
Zfish  2179 HTYLRTKKKLRVDTEEWIATVEVLLSKSSEACQWMVQYLVAPEGREIIKICLLECSVREVRVVVA 2243

  Fly   687 -------------------------LQLAWTDVP---------------------GPLPPFNPKT 705
                                     |.|...|||                     ||..
Zfish  2244 TILEKTLESALYFQDAGLDCLLDMLLSLLDKDVPDNCKNCSQYFSLFSNFAQRGCGPCQ------ 2302

  Fly   706 ESLLFLKYYDPRNKRLNYIGCTQQPHTRR------------------LIDLVPDVNSKLGFEPDT 752
               |.||:...|...:..:|..:|.:..|                  |:.|..|:.|:     .|
Zfish  2303 ---LLLKHSAYRRMLVFLLGPNRQNNQHRRWSSAQAREFLHLHNTLALMVLHTDLTSQ-----RT 2359

  Fly   753 ELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEI 817
            |.....:.|...||     ..|::.:|. |...:.|:|:.:.                ..|.:|:
Zfish  2360 EAQGVFKQASSGLV-----APSSVLMPL-HPDINTLLFKADG----------------QAYLMEV 2402

  Fly   818 IFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGT 882
            :|:.:.......|.:|:   ..|....|        :|..|.....:.|:.||   |.|:..|..
Zfish  2403 MFAMRELSGPLSFLIEM---ITYSSFCN--------EPFSLGVLQLLKNHLET---APPHELKNV 2453

  Fly   883 IKDLVSYTK-----QSSTKRIFYQR---LSLSIHE---LDNKKQFKCVWVSSDLKDEKELVLYPN 936
            .:.|:....     ||...:..::.   |...:|:   :|:.:.::||         |.||....
Zfish  2454 FQMLLEILMLEDPLQSQRLKFAFESEKGLLALMHQSNNVDSSRCYQCV---------KFLVTLAQ 2509

  Fly   937 KNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKT 1001
            |....|...:|.:...|:|....:|    |:|.|...       |...:  |||: :||:..|:|
Zfish  2510 KCSPAKDYFKELSGHWSWAVQWLQK----KMSEHYWT-------PQSNV--SNET-STAKTFQRT 2560

  Fly  1002 FRIEEVPA 1009
            ...::..|
Zfish  2561 ISAQDTLA 2568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	212/983 (22%)
		peptidase_C19C	239..549	CDD:239124	109/375 (29%)
		USP7_ICP0_bdg	647..886	CDD:289221	52/364 (14%)
		USP7_C2	897..1113	CDD:291217	26/119 (22%)
usp24	XP_005170208.1	UBA_UBP24	7..43	CDD:270472
		peptidase_C19C	1691..2048	CDD:239124	108/357 (30%)
		UCH	1693..2043	CDD:278850	106/350 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810