DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp25

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_006523118.1	Gene:	Usp25 / 30940	MGIID:	1353655	Length:	1134	Species:	Mus musculus

Alignment Length:	970	Identity:	184/970 - (18%)
Similarity:	301/970 - (31%)	Gaps:	422/970 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 VGLKNQGATCYMNSLLQTLYFTNSLRLSV--YRIPTEADDSSKSVGLSLQRVFHELQFGDR---- 299
            |||||.|.||:.::::|:|:.....|..|  |:.|:.|.|..::     |:....|.|...
Mouse   169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRN-----QKEHRNLPFMRELRYL 228

  Fly   300 ---PVGTKK--LTKSFGWETL-DSF-----MQHDVQEFLRVLLDKL-------------ESKMKG 340
               .||||:  :..|...|.| |:|     .|.||.||...|||.|             |.|.|.
Mouse   229 FALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKN 293

  Fly   341 TILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLN-IKDKKNIYESFQDYVAPETLEGDN 404
            .::|     ||.|:..:....:...:.:|.....|.:|:| .||.....|:.......|:|..||
Mouse   294 PMVE-----LFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSDN 353

  Fly   405 KYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL----- 464
            ...:|    ||.    .||..||||...|.||:::.......|.:::.||.:.:.||||:
Mouse   354 SGKSG----QEH----WFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNRE 410

  Fly   465 ----------------------------------------------------------------- 464

Mouse   411 ITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDAS 475

  Fly   465 ----------------------------------------------------------------- 464

Mouse   476 SSASGPLPSQSLPSTTEQQGPCASDLPGSSSPASGAALPLRSVIHKPFTQSRIPPDLPMHPAPRH 540

  Fly   465 -----------------AESENTLAD-------------------------YVLHAVLVHSGDNH 487
                             .|.||...|                         |.|||||||.|..:
Mouse   541 ITEEELCVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQAN 605

  Fly   488 GGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELD 552
            .|||..:|....:.||.|::|..|:....:|.:..::||.        :.::||.|:||
Mouse   606 AGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGY--------RNASAYCLMYI------ 656

  Fly   553 RVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVI---LEENFEEQHKRRLFDLE 614
                        .|..:.|     |:....||.|:|  .|.:..:   |.:..||.::|...:||
Mouse   657 ------------DDKAQFL-----IQEEFNKETGQA--LVGMETLPPDLRDFVEEDNQRFEKELE 702

  Fly   615 KVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQISTS 679
            :...   ::.|....::|:       ...:.|....:..|||          |.|:..:||.|.|
Mouse   703 EWDT---QLAQRSLQEKLL-------AAPKLREAEASATTAQ----------AGGADYLEQPSRS 747

  Fly   680 --QKPW------VIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLI 736
              .|.|      ||.......:..||        |::|..|   |.|.      .:|.|.:::.:
Mouse   748 DLSKHWKEETLRVIAKASHDLEDKGP--------ETVLQSK---PANT------TSQPPSSQQGV 795

  Fly   737 DL-VPD-----VNSKLG--------FEPDTEL-----------------TIYD------------ 758
            :: :|.     :.:|.|        |:|..::                 ::||
Mouse   796 EVEIPHLGKFVIEAKEGGYDDEQASFQPPWQVMMTPSMQGVIMAIGKSRSVYDRCGPEAGFFKAI 860

  Fly   759 --EYADKKLVNL---NEPIESALFIPQDHLQGHILIFEREN-VDAKLDLPTVGDYFLDLVYRIEI 817
              ||:  :||.|   :.|.|:      |:...|:|::..:| ...|:...|:.:.|.|.    .:
Mouse   861 KLEYS--RLVKLAQEDTPPET------DYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDR----NL 913

  Fly   818 IFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQ----------------------- 859
            .|.::|              :|..::|.|..|.:..:...|:
Mouse   914 SFDERC--------------HNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETTMYLITGL 964

  Fly   860 -------------FFMC-INNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSL 905
                         |.:| ..|.||..... ||  :|...:|:|:.::....::..|...|
Mouse   965 ENFQRESYIDSLLFLLCAYQNNKELLSKG-PY--RGHDGELISHYRRECLLKLNEQAAEL 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	184/970 (19%)
		peptidase_C19C	239..549	CDD:239124	104/515 (20%)
		USP7_ICP0_bdg	647..886	CDD:289221	59/332 (18%)
		USP7_C2	897..1113	CDD:291217	2/9 (22%)
Usp25	XP_006523118.1	UBA_UBP25	15..60	CDD:270539
		UBP14	<169..637	CDD:227532	96/485 (20%)
		Peptidase_C19I	170..656	CDD:239130	101/511 (20%)
		USP25_C	847..1127	CDD:380451	36/204 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900