Protein Alignment Usp7 and Usp47

DIOPT Version :9

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_006230106.1
• Gene: Usp47 / 308896
• RGDID: 1310411
• Length: 1395
• Species: Rattus norvegicus
• Alignment Length: 1258
• Identity: 279/1258 - (22%)
• Similarity: 454/1258 - (36%)
• Gaps: 387/1258 - (30%)

  Fly   130 WRIMVIPNDRALGFFLQCNGENDSPTWSC-------NAIAELRLKCHKPDAQPFTRARIKHLFYS 187
            ||......|.....|||.....:.|...|       :.....|:..:.|.:.|     ::.||..
  Rat    17 WRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITVNLPASTP-----VRKLFED 76

  Fly   188 KENDYGYSN---FITW-----------------QELKDS-----EKSYVH--------------- 212
            ..|..||.|   .:||                 :.|.|:     :|:::|
  Rat    77 VANKVGYINGTFDLTWGNGINTADLAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQMLLDD 141

  Fly   213 NNSITLEVH--VVADAPH------------------GVLWDSKKHTGYVGLKNQGATCYMNSLLQ 257
            ::.:...||  .:...|.                  .:|  :|..||||||.||..|||:|||||
  Rat   142 SSHVDDSVHDRFIGPLPREGSVASTSDYVSQSYSYSSIL--NKSETGYVGLVNQAMTCYLNSLLQ 204

  Fly   258 TLYFTNSLRLSVYRIPTE--ADDSSKSVGLSLQRVFHELQFG-DRPVGTKKLTKSFGWETLDSFM 319
            ||:.|...|.::|:...|  .:|...|:...|||:|..||.. .|.:.|..:|:||||::.:::.
  Rat   205 TLFMTPEFRNALYKWEFEESEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQ 269

  Fly   320 QHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDK 384
            ||||||..||:.|.||.|.|.|.....|..|::||:..|::|....|...|.:|:.||.|.|:..
  Rat   270 QHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPY 334

  Fly   385 ------KNIYESFQDYVAPETLEGDNKY---------DAGVHGLQEASKGVIFTSFPPVLHLHLM 434
                  .::.|:...::.||.|:|.|:|         |        |.||:.|..||.:|.|.|.
  Rat   335 GSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCD--------ARKGLRFLHFPYLLTLQLK 391

  Fly   435 RFQYDPVTDSSIKYNDRFEFYEHINLDRYL-----------------AESE-------------- 468
            ||.:|..|...||.|||..|.|.:::..::                 ||:|
  Rat   392 RFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFST 456

  Fly   469 ----------------------------------------------NTLADYVLHAVLVHSGDNH 487
                                                          |:|. |.|.:|:||||...
  Rat   457 DDAVDEGICLESSTGSEKISKPGLEKVEMAETDQRKDSIQFQLGEPNSLM-YELFSVMVHSGSAA 520

  Fly   488 GGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFH----AKCSNAYMLVYIRQ 548
            ||||...|...:|.:|:.|:|..||.. .||.|::.:||......::    |..:|||||:| |.
  Rat   521 GGHYYACIKSFSDDQWYSFNDQHVSRI-TQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIY-RL 583

  Fly   549 SELDRVLGDITESEISSDLVERLDLEKRIEMARRKERG-EANT-------YVSVHVILEENFEEQ 605
            .:..|....:...|....:...:..|:.:|...:::|. |.||       ...|..::.||..|.
  Rat   584 KDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEV 648

  Fly   606 HK-----------RRLFDLEKVHP----RVFRIKQNQTVDELVDLFVRGF-GVSRQRMRMWNLCT 654
            ||           .::.|||.|.|    |:.:      .||..|...|.: |.....|   .|..
  Rat   649 HKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVK------YDEFHDYLERSYEGEEDTPM---GLLL 704

  Fly   655 AQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNK 719
            ...:....||.:.| :|..:||..|.||..:.:::...|:         |.|::
  Rat   705 GGVKSTYMFDLLLE-TRKPDQIFQSYKPGEVMVKVHVVDL---------KAETV----------- 748

  Fly   720 RLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQ 784
                    ..|.|.|                        .|.::.::...:.|..|..:|.:.::
  Rat   749 --------AAPVTVR------------------------AYLNQTVLEFKQLISKATHLPAEPMR 781

  Fly   785 GHILIFERENVDAKL------DLPTVGDYFLDLVYRIEIIFSDKCNPNEPDFT----LELSNRYN 839
               ::.||...|.:|      .|...|.:..:.|:    :.|.:...::..||    .:|.:|:
  Rat   782 ---IVLERCYNDLRLLSMPSKTLKAEGFFRSNKVF----VESSETVDHQAAFTDSHLWKLLDRH- 838

  Fly   840 YDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTK------------- 891
                ||.:...:....|....:.....|::..|::      |.:.|.....|
  Rat   839 ----ANTIRLFVLLPEQSPGSYSKRTAYQKAGGDS------GNVDDDCERAKGPAGSLKSVDAIL 893

  Fly   892 QSSTKRIFYQRLSLSIHEL---DNKKQFKCVWV--------------SSDLKDEKELVLYPNKND 939
            :.||:::    .|||:.:.   ||....|....              ||...|.:||..:...:|
  Rat   894 EESTEKL----KSLSLQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSD 954

  Fly   940 TVKGLLEEAAKKISFAENSRRKLRL---LKISNHKIVAVCKDD---IPLDTLLKSNESITTA--- 995
            ......||  :..|...|.|....:   :..|:|....:|..|   |||...|.|: |||::
  Rat   955 PENFQSEE--RSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSH-SITSSRRT 1016

  Fly   996 ---QGAQKTF-RIEEVPAEDMQLAEN-------EFLIPVAHFSKELYNSFGIPFLTKARQGEPYG 1049
               :|.::|: ..||....|.:..|:       :::    :|..:       |:......||.:.
  Rat  1017 KANEGKKETWDTAEEDSGTDSEYDESGKSRGEMQYM----YFKAD-------PYTADEGSGEGHK 1070

  Fly  1050 ALKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDNTPVDLEVYRSWTSGQ----------LPFF 1104
            .|...:.:|:.:...:.....|..:...|           .:|:|.:||.|          |..|
  Rat  1071 WLMVHVDKRITLAAFKQHLEPFVGVLSSH-----------FKVFRVYTSNQEFETVRLNETLSSF 1124

  Fly  1105 GLDHINKSRKRSSLNFSEKAIKI 1127
            ..|:....|...:|...|..:|:
  Rat  1125 SDDNKITIRLGRALKKGEYRVKV 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	26/165 (16%)
		COG5077	101..1119	CDD:227409	276/1248 (22%)
		peptidase_C19C	239..549	CDD:239124	127/408 (31%)
		USP7_ICP0_bdg	647..886	CDD:289221	39/248 (16%)
		USP7_C2	897..1113	CDD:291217	51/262 (19%)
Usp47	XP_006230106.1	peptidase_C19C	186..586	CDD:239124	127/410 (31%)
		UCH	187..581	CDD:278850	124/403 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820