DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp7 and USP25

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001269970.1	Gene:	USP25 / 29761	HGNCID:	12624	Length:	1125	Species:	Homo sapiens

Alignment Length:	1042	Identity:	190/1042 - (18%)
Similarity:	339/1042 - (32%)	Gaps:	423/1042 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 VGLKNQGATCYMNSLLQTLYFTNSLRLSV--YRIPTEADDSSKSVGLSLQRVFHELQFGDR---- 299
            |||||.|.||:.::::|:|:.....|..|  |:.|:.|.|..::     |:....|.|...
Human   169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRN-----QKEHRNLPFMRELRYL 228

  Fly   300 ---PVGTKK--LTKSFGWETL-DSF-----MQHDVQEFLRVLLDKL-------------ESKMKG 340
               .||||:  :..|...|.| |:|     .|.||.||...|||.|             |.|.|.
Human   229 FALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKN 293

  Fly   341 TILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNK 405
            .::|     ||.|:..:....:...:.:|  |.|....|.:...|:::|..:..:....:|..:.
Human   294 PMVE-----LFYGRFLAVGVLEGKKFENT--EMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHS 351

  Fly   406 YDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL------ 464
            .::|..|.:.     .||..||||...|.||:::.......|.:::.||.:.:.||||:
Human   352 ENSGKSGQEH-----WFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREI 411

  Fly   465 ----------------------------------------------------------------- 464

Human   412 TRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASS 476

  Fly   465 ----------------------------------------------------------------- 464

Human   477 PPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHIT 541

  Fly   465 ---------------AESENTLAD-------------------------YVLHAVLVHSGDNHGG 489
                           .|.||...|                         |.|||||||.|..:.|
Human   542 EEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAG 606

  Fly   490 HYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRV 554
            ||..:|....:.||.|::|..|:....:|.:..::||.        :.::||.|:||
Human   607 HYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGY--------RNASAYCLMYI-------- 655

  Fly   555 LGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVI---LEENFEEQHKRRLFDLEKV 616
                      :|..:.|     |:....||.|:  ..|.:..:   |.:..||.::|...:||:.
Human   656 ----------NDKAQFL-----IQEEFNKETGQ--PLVGIETLPPDLRDFVEEDNQRFEKELEEW 703

  Fly   617 HPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSR---------- 671
            ..   ::.|....::|         ::.|::|.........|.....:::.:.||
Human   704 DA---QLAQKALQEKL---------LASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEE 756

  Fly   672 TIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQP-HTRRL 735
            ||:.|:.:.....                 :...|::|..|   |.|       .|.|| ..:|:
Human   757 TIQIITKASHEHE-----------------DKSPETVLQSK---PEN-------TTSQPLSNQRV 794

  Fly   736 IDL-VPDVNSKL------GFEPDTELT---------------IYD--------------EYADKK 764
            ::: :|.|...:      |::.:..:|               :||              |||  :
Human   795 VEVAIPHVGKFMIESKEGGYDDEIMMTPNMQGIIMAIGKSRSVYDRCGPEAGFFKAIKLEYA--R 857

  Fly   765 LVNL---NEPIESALFIPQDHLQGHILIFEREN-VDAKLDLPTVGDYFLDLVYRIEIIFSDKCNP 825
            ||.|   :.|.|:      |:...|::::..:| ...|:...|:.:.|.|.    .:.|.::|
Human   858 LVKLAQEDTPPET------DYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDR----NLSFDERC-- 910

  Fly   826 NEPDFTLELSNRYNYDQLANAVAERLNTDPQKL----QFFMCINNYKETAGNAVPYTFKGTIKDL 886
                        :|..::|.|..|.:..:...|    ::......::||    ..|...|    |
Human   911 ------------HNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRET----TMYLIIG----L 955

  Fly   887 VSYTKQSSTKRIFYQRLSLSIHELDNKKQFKCVWVSSDL--KDEKELVLYPNKNDTVKGLLEEAA 949
            .::.::|     :...|...|....|.|:.    :|..|  ..::||:.:..:...:| |.|:||
Human   956 ENFQRES-----YIDSLLFLICAYQNNKEL----LSKGLYRGHDEELISHYRRECLLK-LNEQAA 1010

  Fly   950 KKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEE---VPAED 1011
            :.....|:  |::      |:.::.:.:..:|...||..:|             :||   :..||
Human  1011 ELFESGED--REV------NNGLIIMNEFIVPFLPLLLVDE-------------MEEKDILAVED 1054

  Fly  1012 MQ 1013
            |:
Human  1055 MR 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	190/1042 (18%)
		peptidase_C19C	239..549	CDD:239124	99/513 (19%)
		USP7_ICP0_bdg	647..886	CDD:289221	48/293 (16%)
		USP7_C2	897..1113	CDD:291217	25/122 (20%)
USP25	NP_001269970.1	UBA_UBP25	15..60	CDD:270539
		SUMO interaction domain (SIM)	77..102
		Required for SUMO paralog-specific binding	89..95
		UCH	168..>405	CDD:278850	68/252 (27%)
		Peptidase_C19I	170..655	CDD:239130	96/509 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..507		0/42 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..749		3/21 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900