Protein Alignment Usp7 and ubp15

DIOPT Version :9

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_595341.1
• Gene: ubp15 / 2541131
• PomBaseID: SPBC713.02c
• Length: 1129
• Species: Schizosaccharomyces pombe
• Alignment Length: 1182
• Identity: 381/1182 - (32%)
• Similarity: 560/1182 - (47%)
• Gaps: 234/1182 - (19%)

  Fly    83 DGEAMGID-----DESKEDQFRSE---------------------TTFSFTVENVVQLKSQRLSP 121
            |.|.:.:|     :||.::..|::                     .::|:.|:|...|:.:..||
pombe     7 DAEEVNMDSSMELEESSQEPLRADNYEEIYNSLVHHEPDLEEAAHASYSWVVKNFSTLEDKTYSP 71

  Fly   122 PVYVRMLPWRIMVIPN--------DRALGFFLQCNGE----------------------NDSPTW 156
            ........|||::.|.        ...|.:..||..|                      ||. |:
pombe    72 LFKAGHTTWRIVLFPKGCNQTEYASVFLEYLPQCKVEAIRKYEAELAAGKTPTIDPEIVNDE-TY 135

  Fly   157 SCNAIAELRLKCHKPDAQPFTRARIK---HLFYSKENDYGYSNFITWQEL----KDSEKSYVHNN 214
            ||.|...|.|.    :.|..|..:|.   |.|.|:..|:|::.|:..:::    .:....::.|:
pombe   136 SCCAQFALSLS----NVQDPTVMQINTSHHRFRSEVKDWGFTRFVDLRKIAVPTPEFPVPFLEND 196

  Fly   215 SITLEVHV-VADAPHGVLW------DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRI 272
            .|.:.|.| |...|.||||      :|||.||||||||||||||||||||:|:|||..|.:||:|
pombe   197 EICISVTVRVLQDPTGVLWHSFVNYNSKKETGYVGLKNQGATCYMNSLLQSLFFTNIFRKTVYKI 261

  Fly   273 PTEADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESK 337
            ||:.|||..||..:|||||:.|:....||.|.:||:||||.:.|||||||:|||.|||.|.||.|
pombe   262 PTDNDDSRDSVAYALQRVFYNLEKQREPVSTTELTRSFGWNSFDSFMQHDIQEFNRVLQDNLEKK 326

  Fly   338 MKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEG 402
            ||||.:|..:..:|.|||.||:||.:|:|.|:|.|.|:|||||:|....:.:||:|.:..|||.|
pombe   327 MKGTEVENALNDIFVGKMKSYVKCIDVNYESSRVEDFWDIQLNVKGMDTLEDSFRDAIQVETLTG 391

  Fly   403 DNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAES 467
            ||||.|..||||:|.||:||.|.|.||.|.|.||.||.:.|..:|.|||.||...|:|:.||:|:
pombe   392 DNKYYAEGHGLQDAHKGIIFESLPNVLQLQLKRFDYDMLRDMMVKINDRHEFPLEIDLEPYLSET 456

  Fly   468 ENTLAD------YVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYGG 526
                ||      ||||.||||.||.|||||...|.|:.|..|||||||.|:....:|.:|.||||
pombe   457 ----ADKSESHVYVLHGVLVHGGDLHGGHYYALIKPEKDSNWFKFDDDRVTRATIKEVLEDNYGG 517

  Fly   527 MDDEISFHAK---------CSNAYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARR 582
               |.:..||         ..|||||||.|:|.||.:|..:|..::...:...||.|.|:...:.
pombe   518 ---EPAGRAKGYNGNPFKRFMNAYMLVYFRKSRLDHILSPVTAEDVPFHVRNTLDEEHRVVERKL 579

  Fly   583 KERGEANTYVSVHVILEENFEEQH---------------------KR--RLFDLEK--------- 615
            .||.|...|..|.|:..:.|::.|                     ||  .::||:|
pombe   580 LEREEQQIYRRVRVLTTDGFKKYHGFDMTDFSASDDDPVLITTKIKRNANIWDLQKHLAGLLNRD 644

  Fly   616 ---VHPRVFRIKQNQT-------------VDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFD 664
               :...:...:||:|             ||::.|:.:|    ....||:            :.:
pombe   645 TSGIRIWLMTNRQNRTVRVDLPLDKKTILVDQICDMHIR----KDMDMRV------------YVE 693

  Fly   665 FVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQ 729
            |::|.::.:.....             ||        :...::.:|||.:|...::::.:.....
pombe   694 FLSEHNQLLADFGA-------------TD--------DNDFDTYIFLKIFDYETQQISGLADLHV 737

  Fly   730 PHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLNEPIESALFIPQDHLQGHILIFEREN 794
            .....:..|...:...|.:..|..:|.|:| ....:|::.:|  :|.|...:...|.|:.||::.
pombe   738 SKNSPISSLSEWIREHLKWSSDVPITYYEE-IKTGMVDVLDP--NASFEKSEIQVGDIICFEKKL 799

  Fly   795 V-DAKLDLPTVGDYFLDL----VYRIEIIFSDKC--NPNEPDFTLELSNRYNYDQLANAVAERLN 852
            | |:..|........|||    .:|:.|.|..:.  :.|...|.|.|:...||..:|.|||.:||
pombe   800 VHDSSSDTSHPYKSALDLYDFMAHRVVITFEPRYSDDTNNGVFDLVLTTHTNYTDMARAVANKLN 864

  Fly   853 TDPQKLQFFMC-----------INNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLS 906
            .||..|||.|.           .|..|.|..||:|.|:           ..:....:||:.|.::
pombe   865 VDPNYLQFTMAHLPSRTPRSVIRNPSKFTLQNAIPSTY-----------SHNQNVVMFYEVLDIT 918

  Fly   907 IHELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHK 971
            :.||:.|:..:..::|:.:..|.::..|.:|..||:.:|.:..:|:........:|||.::.||:
pombe   919 LSELERKQLIRVHFLSNGISHETQMEFYVDKEGTVEDILRQVTQKVPLNAEDASRLRLYEVYNHR 983

  Fly   972 IVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAED-MQLAENEFL-IPVAHFSKELYNSF 1034
            |:   |..:|.|.:...|| .:||.       :|..|.|: |||..::.: |.|.||.|:|....
pombe   984 IL---KSHLPTDGIYDLNE-FSTAY-------VEVTPKEEQMQLKTDDAVSIVVQHFFKDLSRLH 1037

  Fly  1035 GIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVI---SMGHNADVNDNTPVDLEVYRSW 1096
            .|||.....:||....||:|:|:||...|.::...|..|:   |.|....:.|    |.||....
pombe  1038 DIPFYFVLLRGETLKDLKKRLQKRLGYNDTQFSKVKLAVLQAQSFGKPYYLTD----DDEVLYGE 1098

  Fly  1097 TSGQLPFFGLDH 1108
            ...|....||||
pombe  1099 LEPQSHILGLDH 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	37/187 (20%)
		COG5077	101..1119	CDD:227409	375/1159 (32%)
		peptidase_C19C	239..549	CDD:239124	179/324 (55%)
		USP7_ICP0_bdg	647..886	CDD:289221	58/256 (23%)
		USP7_C2	897..1113	CDD:291217	64/217 (29%)
ubp15	NP_595341.1	COG5077	13..1129	CDD:227409	379/1176 (32%)
		MATH_Ubp21p	52..205	CDD:239744	34/157 (22%)
		peptidase_C19C	228..547	CDD:239124	179/325 (55%)
		USP7_ICP0_bdg	648..888	CDD:289221	58/279 (21%)
		USP7_C2	909..1111	CDD:291217	64/217 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	334	1.000	Domainoid score	I199
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2592
Inparanoid	1	1.050	498	1.000	Inparanoid score	I244
OMA	1	1.010	-	-		QHG55761
OrthoFinder	1	1.000	-	-		FOG0003101
OrthoInspector	1	1.000	-	-		otm47323
orthoMCL	1	0.900	-	-		OOG6_101317
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2325
SonicParanoid	1	1.000	-	-		X2073
TreeFam	1	0.960	-	-
	14	13.860