DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp7

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_006522201.1	Gene:	Usp7 / 252870	MGIID:	2182061	Length:	1143	Species:	Mus musculus

Alignment Length:	1161	Identity:	548/1161 - (47%)
Similarity:	758/1161 - (65%)	Gaps:	85/1161 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ILTSDLQQTQQQ-----------RNSPPQLP------KFKNLIQPQLHAV----------GAVTQ 59
            |||.|.....|.           |.:||::|      ||..:..|....:          ..:||
Mouse    15 ILTQDTIYFPQSNIISELLPWYLRYTPPEVPSTSVITKFILVNCPWNEGIEYQAGDTDDPPRITQ 79

  Fly    60 LPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVY 124
            .|..|||:            :..||.:...:|...:..:|||.||.||||...:|....||||.:
Mouse    80 NPVINGNV------------TLSDGHSNAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCF 132

  Fly   125 VRMLPWRIMVI-------PNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIK 182
            ||.|||:|||:       |:.:::|||||||.|:||.:|||:|.|.|::..::.|.:.|:| ||.
Mouse   133 VRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDDKSFSR-RIS 196

  Fly   183 HLFYSKENDYGYSNFITWQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQG 247
            |||:.||||:|:|||:.|.|:.|.||.::.::.:|.||.|.|||||||.||||||||||||||||
Mouse   197 HLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQG 261

  Fly   248 ATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFGDRPVGTKKLTKSFGW 312
            ||||||||||||:|||.||.:||.:|||.|||||||.|:|||||:|||..|:|||||||||||||
Mouse   262 ATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGW 326

  Fly   313 ETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDI 377
            |||||||||||||..|||||.:|:|||||.:|||||.||.|||.|||:||:|||.|.|.|.:|||
Mouse   327 ETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKDVDYRSDRREDYYDI 391

  Fly   378 QLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVT 442
            ||:||.||||:|||.||||.|.|:||||||||.||||||.|||.|.:.||||||.||||.|||.|
Mouse   392 QLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQT 456

  Fly   443 DSSIKYNDRFEFYEHINLDRYLAESE-NTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKF 506
            |.:||.||||||.|.:.||.:|.::: ...|:|:||||||||||||||||||::|||.||:|.||
Mouse   457 DQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKF 521

  Fly   507 DDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELDRVLGDITESEISSDLVERL 571
            ||||||.|.|:||||.||||.||::|.. .|:|||||||||:|:|..||..:|:.:|...|||||
Mouse   522 DDDVVSRCTKEEAIEHNYGGHDDDLSVR-HCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERL 585

  Fly   572 DLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELVDLF 636
            ..|||||..:||||.||:.|:.|.::.|:.|.......::|.|||...||::.:|.::.|.|...
Mouse   586 QEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSLAEFVQSL 650

  Fly   637 VRGFGVSRQRMRMWNLCTAQ--TQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVP---G 696
            .:..|..:.::|:|.:....  |::.:..|..|:|::|:.::|.::.||.|:|:....::.   .
Mouse   651 SQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGA 715

  Fly   697 PLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYA 761
            .||.|:...:.:||||.|||:.:.|||.|....|.:.::.||:|.:..:.||..||.|.:|:|..
Mouse   716 TLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVK 780

  Fly   762 DKKLVNLNEPI-------ESALFIPQDHLQGHILIFERENVD-AKLDLPTVGDYFLDLVYRIEII 818
            .    ||.|.|       :.||   .:.:.|.|::|::::.: ...:|||..:||.||.:|:::|
Mouse   781 P----NLTERIQDYDVSLDKAL---DELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVI 838

  Fly   819 FSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGTI 883
            |.||..||:|.|.:.||||.||.|:|..||:||||||..||||.. ..|::..||.:.:.::||:
Mouse   839 FCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKS-QGYRDGPGNPLRHNYEGTL 902

  Fly   884 KDLVSYTKQSSTKRIFYQRLSLSIHELDNKKQFKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEA 948
            :||:.:.|....|:::||:|.:.|.:.:|::.|||:|::|..::| |:.|||:|:..|:.||||.
Mouse   903 RDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREE-EITLYPDKHGCVRDLLEEC 966

  Fly   949 AKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFRIEEVPAEDMQ 1013
            .|.:...:.:..:||||:|.::||:.|.::|..|:.|         :....:||||||:|.:.:.
Mouse   967 KKAVELGDKASGRLRLLEIVSYKIIGVHQEDELLECL---------SPATSRTFRIEEIPLDQVD 1022

  Fly  1014 L-AENEFLIPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMG 1077
            : .|||.||.||||.||::.:||||||.:..|||.:..:.:|||..|::|:||:|.:||.::.||
Mouse  1023 IDKENEMLITVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMG 1087

  Fly  1078 HNADVN-DNTPVDLEVYRSW---TSGQLPFFGLDHINKSRKRSSLNFSEKAIKIYN 1129
            .:..:| |...|:|:.:...   .|...|:.||||.||:.|||...:.||||||:|
Mouse  1088 RHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	67/135 (50%)
		COG5077	101..1119	CDD:227409	518/1043 (50%)
		peptidase_C19C	239..549	CDD:239124	228/310 (74%)
		USP7_ICP0_bdg	647..886	CDD:289221	87/251 (35%)
		USP7_C2	897..1113	CDD:291217	84/220 (38%)
Usp7	XP_006522201.1	COG5077	96..1141	CDD:227409	524/1053 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842286
Domainoid	1	1.000	458	1.000	Domainoid score	I489
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2592
Inparanoid	1	1.050	1035	1.000	Inparanoid score	I269
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55761
OrthoDB	1	1.010	-	-		D387934at33208
OrthoFinder	1	1.000	-	-		FOG0003101
OrthoInspector	1	1.000	-	-		oto94266
orthoMCL	1	0.900	-	-		OOG6_101317
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2325
SonicParanoid	1	1.000	-	-		X2073
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800