DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp7 and Usp18

DIOPT Version :10

Sequence 1:NP_572779.2 Gene:Usp7 / 32169 FlyBaseID:FBgn0030366 Length:1129 Species:Drosophila melanogaster
Sequence 2:NP_036039.2 Gene:Usp18 / 24110 MGIID:1344364 Length:368 Species:Mus musculus


Alignment Length:357 Identity:87/357 - (24%)
Similarity:153/357 - (42%) Gaps:31/357 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   205 DSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSV 269
            :.|::......::.::....|:|||:          |||.|.|.||.:|||||........|:.:
Mouse    26 EEERTMKRKRVLSRDLCSAWDSPHGL----------VGLHNIGQTCCLNSLLQVFMMNMDFRMIL 80

  Fly   270 YRI--PTEADDSSKSVGLSLQRVFHELQFG-DRPVGTKKLTKSFGWETLDSFMQHDVQEFLRVLL 331
            .||  |..|::..:||...|..:..::|.. .:.|...:|.:......:..|:|||..:....:.
Mouse    81 KRITVPRSAEERKRSVPFQLLLLLEKMQDSRQKAVLPTELVQCLQKYNVPLFVQHDAAQLYLTIW 145

  Fly   332 DKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDK-----KNIYESF 391
            :..:.::..|.|...:.|||.......:.|......|:|......:.|.:.||     |.:.::.
Mouse   146 NLTKDQITDTDLTERLQGLFTIWTQESLICVGCTAESSRRSKLLTLSLPLFDKDAKPLKTLEDAL 210

  Fly   392 QDYVAPETLEGDNKYDAGVHGLQEASKGVI-FTSFPPVLHLHLMRFQ-YDPVTDS---SIKYNDR 451
            :.:|.|:.|...:...... |.:...|.|: .|..|..|.:|||||. .:..|:.   |:.:...
Mouse   211 RCFVQPKELASSDMCCESC-GEKTPWKQVLKLTHLPQTLTIHLMRFSARNSRTEKICHSVNFPQS 274

  Fly   452 FEFYEHINLDRYLAES-ENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCR 515
            .:|.:.:..:..|.:: |.:...|.|.||:.|.|....|||..:|....||:||.|:|..|....
Mouse   275 LDFSQVLPTEEDLGDTKEQSEIHYELFAVIAHVGMADFGHYCAYIRNPVDGKWFCFNDSHVCWVT 339

  Fly   516 KQEAIEQNYGGMDDEISFHAKCSNAYMLVYIR 547
            .:: ::..||.     ..:.....||:|||.:
Mouse   340 WKD-VQCTYGN-----HRYRWRETAYLLVYTK 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp7NP_572779.2 Peptidase_C19 101..1119 CDD:470612 87/357 (24%)
Usp18NP_036039.2 Mediates interaction with IFNAR2. /evidence=ECO:0000250|UniProtKB:Q9UMW8 31..48 1/16 (6%)
Mediates interaction with STAT2. /evidence=ECO:0000250|UniProtKB:Q9UMW8 48..109 23/70 (33%)
UCH 52..363 CDD:425685 80/317 (25%)
Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000250|UniProtKB:Q9UMW8 299..308 4/8 (50%)
Mediates interaction with IFNAR2. /evidence=ECO:0000250|UniProtKB:Q9UMW8 309..368 18/63 (29%)

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