DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and USP24

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_016856320.1	Gene:	USP24 / 23358	HGNCID:	12623	Length:	2640	Species:	Homo sapiens

Alignment Length:	983	Identity:	210/983 - (21%)
Similarity:	348/983 - (35%)	Gaps:	303/983 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQFG 297
            ||:..:|:|||:|.|||||||::.|.||....|..|:..:..:.|:...||...:|.:|..|...
Human  1701 DSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDSVFYQVQSLFGHLMES 1765

  Fly   298 DR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSY 358
            ..    |....|:.|.:..| |....|.|..||...|:|:::..:|....:......|:|..|..
Human  1766 KLQYYVPENFWKIFKMWNKE-LYVREQQDAYEFFTSLIDQMDEYLKKMGRDQIFKNTFQGIYSDQ 1829

  Fly   359 IKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYDAGVHGLQE---ASKGV 420
            ..||:..:...|.|.|..:.|.:...:::..|...:|..|.|||.|.|..  ...:|   ..|..
Human  1830 KICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYC--EKCKEKRITVKRT 1892

  Fly   421 IFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRY---------------------- 463
            ...|.|.||.:|||||.:|..:..||||:::..|...:|::.|
Human  1893 CIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSGMARQDSSSEVGENGRSVD 1957

  Fly   464 ----------LAESENTLADYVLHAVLVHSGDNHGGHYVVFINPK---ADGRWFKFDDDVVSSC- 514
                      :|.:||    |.|..|:||||..|.|||..||..:   ..|:|:||:|.|:...
Human  1958 QGGGGSPRKKVALTEN----YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFD 2018

  Fly   515 RKQEAIE-QNYGG-----MDDEIS----FHAKCSNAYMLVY-------------------IRQSE 550
            ...|.:| :.:||     :.|:.:    ...:..|||||.|                   :||..
Human  2019 LNDETLEYECFGGEYRPKVYDQTNPYTDVRRRYWNAYMLFYQRVSDQNSPVLPKKSRVSVVRQEA 2083

  Fly   551 LDRVLGDITESEISSDLV--------ERLD-LEKRIEMARRK----ERGEANTYVSVHVILEENF 602
            .|..|...:..|||....        :||. |.|.::...:|    |:..|..|   .::.:||.
Human  2084 EDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIY---QMVRDENL 2145

  Fly   603 EEQHKRRLFDLE------------------KVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRM 649
            :....|.::..:                  ..:|.:.::.....:..|...::|    :::::|:
Human  2146 KFMKNRDVYSSDYFSFVLSLASLNATKLKHPYYPCMAKVSLQLAIQFLFQTYLR----TKKKLRV 2206

  Fly   650 ----WNLCTAQTQKFSHFD--------FVAEGSRTI----------------------------- 673
                | :.|.:......||        |::...|.:
Human  2207 DTEEW-IATIEALLSKSFDACQWLVEYFISSEGRELIKIFLLECNVREVRVAVATILEKTLDSAL 2270

  Fly   674 ---EQISTSQKPWVIWLQLAWTDVPGPLPP-------FNPKTESL------LFLKYYDPRNKRLN 722
               :::.:..:...:.|.|...|||.....       ||...:..      |.|::...|:....
Human  2271 FYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFFLFNTFVQKQGIRAGDLLLRHSALRHMISF 2335

  Fly   723 YIGCTQQ------------------PHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADKKLVNLN 769
            .:|.::|                  .:|..|:.|..||:|:....|.             :....
Human  2336 LLGASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSDVSSQRNVAPG-------------IFKQR 2387

  Fly   770 EPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIE------------IIFSDK 822
            .||..|...|        |:...|.|:|.|.:.....|.|::::.:.            :::...
Human  2388 PPISIAPSSP--------LLPLHEEVEALLFMSEGKPYLLEVMFALRELTGSLLALIEMVVYCCF 2444

  Fly   823 CNPNEPDFTLELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAVPYTFKGT----- 882
            ||.:. .||:                         |.|   |.|..||   |.|:..|.|
Human  2445 CNEHF-SFTM-------------------------LHF---IKNQLET---APPHELKNTFQLLH 2477

  Fly   883 ----IKDLVSYTKQSSTKRIFYQR---LSLSIH--ELDNKKQFKCVWVSSDLKDEKELVLYPNKN 938
                |:|.:...:   .|.:|...   |:|..|  .:|:.:.::||         |.||....|.
Human  2478 EILVIEDPIQVER---VKFVFETENGLLALMHHSNHVDSSRCYQCV---------KFLVTLAQKC 2530

  Fly   939 DTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLKSNESITTAQGAQKTFR 1003
            ...|...:|.:...|:|....:|    |:|.|....            :||.|..|:.|  |||:
Human  2531 PAAKEYFKENSHHWSWAVQWLQK----KMSEHYWTP------------QSNVSNETSTG--KTFQ 2577

  Fly  1004 IEEVPAED 1011
             ..:.|:|
Human  2578 -RTISAQD 2584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	210/983 (21%)
		peptidase_C19C	239..549	CDD:239124	105/381 (28%)
		USP7_ICP0_bdg	647..886	CDD:289221	52/334 (16%)
		USP7_C2	897..1113	CDD:291217	29/120 (24%)
USP24	XP_016856320.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810