DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp34

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_006514628.1	Gene:	Usp34 / 17847	MGIID:	109473	Length:	3583	Species:	Mus musculus

Alignment Length:	554	Identity:	143/554 - (25%)
Similarity:	224/554 - (40%)	Gaps:	140/554 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 LKDSEKSY--VHNNSITLEVHV-VADAPHGVLWDSKKHTG------YVGLKNQGATCYMNSLLQT 258
            :|.|.::|  :||  ..:..|: .|.||:  .||...|..      :|||.|.|||||:.|.:|.
Mouse  1889 VKGSVENYRLIHN--WVMAQHMQSAHAPY--KWDYWPHEDVRAECRFVGLTNLGATCYLASTIQQ 1949

  Fly   259 LYFTNSLRLSVYRIPTEADDSSKSVGLSLQRVFHELQ------FGDRPVGTKKLTKSFGWETLDS 317
            ||.....|.:|:......|...|:..|.||::|..|.      :..||...   |.:...:.|::
Mouse  1950 LYMIPEARQAVFTAKYSEDMKHKTTLLELQKMFTYLMESECKAYNPRPFCK---TYTMDKQPLNT 2011

  Fly   318 FMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIK 382
            ..|.|:.||...|:.|:|.  ....|:.|:..||.|.:::.:...:.::.|...|.||.::..:.
Mouse  2012 GEQKDMTEFFTDLITKVEE--MSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVA 2074

  Fly   383 DKKNIYESFQDYVAPETLEGDNKYDAGVHGLQ-EASKGVIFTSFPPVLHLHLMRFQYDPVTDSSI 446
            |.||||||..:....:||||||.|.....|.: .|.|...|...|.:|..:.||:.::.||....
Mouse  2075 DMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKE 2139

  Fly   447 KYNDRFEFYEHINLDRYLAE------------------SENTLA-DYVLHAVLVHSGDNHGGHYV 492
            |.|..|.|...:::..|..:                  |::|.: :|.|..|.||:|...||||.
Mouse  2140 KVNTHFSFPLRLDMTPYTEDFLMGKSDRKEGFKDVGDRSKDTESYEYDLIGVTVHTGTADGGHYY 2204

  Fly   493 VFI----NPKA--DGRWFKFDD---------DVVSSCRKQEAIEQNYGGMDD---EISFHAKCSN 539
            .||    ||.|  :.:|:.|:|         .:.|.|...|...:.|..:.|   :.||. |..:
Mouse  2205 SFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFE-KTHS 2268

  Fly   540 AYMLVYIRQSELDRVLGDITESEISSDLVERLDLEKRIEMARRKERGEANTYVSVHVILEENFEE 604
            ||||.| ::.|.:...|...:.::||:|:|                          .|..:|.:.
Mouse  2269 AYMLFY-KRMEPEEENGREYKFDVSSELLE--------------------------WIWHDNMQF 2306

  Fly   605 QHKRRLFDLEKVHPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTA-------------Q 656
            ...:.:|:    |..                    ||.      ||.||:.             .
Mouse  2307 LQDKNIFE----HTY--------------------FGF------MWQLCSCIPSTLPDPKAVSLM 2341

  Fly   657 TQKFSHFDFVAEGSRTIEQISTSQKPWVI-WLQL 689
            |.|.| ..||.|     ..|.:.:||.:: |::|
Mouse  2342 TAKLS-TSFVLE-----TFIHSKEKPTMLQWIEL 2369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	9/28 (32%)
		COG5077	101..1119	CDD:227409	143/554 (26%)
		peptidase_C19C	239..549	CDD:239124	104/359 (29%)
		USP7_ICP0_bdg	647..886	CDD:289221	15/57 (26%)
		USP7_C2	897..1113	CDD:291217
Usp34	XP_006514628.1	peptidase_C19C	1930..2279	CDD:239124	104/355 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910