DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and K02C4.3

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_001309441.1	Gene:	K02C4.3 / 174300	WormBaseID:	WBGene00010502	Length:	1261	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	155/838 - (18%)
Similarity:	242/838 - (28%)	Gaps:	365/838 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 RLKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQELKDSEK--------------SY--VHN 213
            |.:| ||..:.|....|..||||.|...|..:......|.|.||              ||  .|.
Worm    55 RSEC-KPTDEQFISDIINELFYSGEPPKGRKSERFIGPLFDPEKASTASGPMDCTDVVSYDSTHP 118

  Fly   214 N------------SITLEVHVVADAPHGV---------LWDSKKHTGY-VGLKNQGATCYMNSLL 256
            |            ...::..:.:.|...:         |.|..::..: .||.|.|.||::|.|.
Worm   119 NISEISKKEEVEMQSAIQQSLASSASQNISRPTMLMSNLEDMVRNPNFSTGLYNSGNTCWLNCLS 183

  Fly   257 QTLYFTNSLRLSVYRIP-----------TEADDSSKSVGLSLQR-VFHELQFGDR---PVG---- 302
            |.||.....|..:|...           .:.::...:..|.|.| :|.||||.:.   .||
Worm   184 QVLYSIPKFRSILYHCAPLSWHEQPITNVKIENQQHAELLMLFRGLFAELQFSEMKYIEVGPLIN 248

  Fly   303 -TKKLTKSF-GWETLDSFMQHDVQEFLRVLLDKLESKMKGTI----------------------- 342
             ..||:||. |..|:.:  |.|..|.|.::.|.|:......:
Worm   249 MVDKLSKSSKGPSTIGT--QQDATEMLTLIFDWLQRAFDAALHAQLNPEFSNVSDEENLVISDST 311

  Fly   343 -------LEGTIPGLFEGKMS---------------SYI---------------KCKNVDYN--- 367
                   :.|..||.....:|               .|:               :.|.::.|
Worm   312 TTAPNSDIIGAPPGYNAANLSLPSSSHVDPKSTLNPMYVNEKEPSSTPTSLFGTRSKTIEVNESM 376

  Fly   368 STRYETFYDIQLN------------IKDKKNIY-----ESFQDYVA----PETLEGD-------- 403
            .|...|..::..|            :.|.|..:     |||.:..:    .|::..|
Worm   377 DTEAATSSNLPGNSVENHPNPAAPEVDDNKKAFCDKLKESFNNIFSSVCYTESVAEDGTVSVKSN 441

  Fly   404 ---------------NKYDA-----GVHGLQEASKGV--IFTSFPPVLHLHLMRFQYDPVTDSSI 446
                           |.:||     ..|||...:..|  ::...|.|:...|.||.::...:|
Worm   442 VRNCPQFFQLQVTYGNLHDALEAATFDHGLGNTASHVRNLYDPLPAVIFFGLSRFSFNSNIES-- 504

  Fly   447 KYNDRFEFYEHINLDRYL----------------------------------------------- 464
            |.:|:|.|.:.|.:||||
Worm   505 KLHDKFTFPKIIFMDRYLKCNKEQLVQLRSHRELCRDSLSEVRAKLSGLRRYPQGNGEVRLEDSF 569

  Fly   465 ----------------------------------------------------------------- 464

Worm   570 QTVWQAVSNFRDREDAHENTAFVGPLTPSTYQSSSDNCSSKFVKDGGKLFPTFTEGFFPGKAAFI 634

  Fly   465 -----------AESENTLAD---------------------YVLHAVLVHSGDNHGGHYVVF-IN 496
                       .|..:.||:                     |.|||::||||:.:.|||..: :.
Worm   635 ETLQNMLEALKTEERDCLAEEARLQEVIDQTYEVPELQQHKYELHAIIVHSGEANRGHYWTYKLK 699

  Fly   497 PKADG--RWFKFDDDVVSSCRKQEAIEQNYG-GMDDEISFHAKCSNAYMLVYIRQSELDRVLGD- 557
            ...||  .|.|.:|.........:....::| |..|       ..:||||:|:|......|..|
Worm   700 KSIDGLEEWEKLNDQNADRVDWPKVESDSFGTGSRD-------APSAYMLMYVRSDAEWLVSADK 757

  Fly   558 ITESE----ISSDLVERLDLEKRIEMARRKERGEAN-----TYVSVHVILEENFEEQ------HK 607
            :|..|    |..||.|:: |:||.|...:.:|...|     ...||.....::.||.      ::
Worm   758 LTALEAFETIPPDLQEKV-LQKRDEFKEKLQRFRENKEFNYQQFSVDSPTVQSTEETPSSFSWYR 821

  Fly   608 RRLFDL----EKVHPRVFRIKQNQTVDELVDLF-------VRGFGVSRQRMRMWNLCT 654
            ..|.|:    |..:|    .|.:..::..:|.:       |....:.|...:|||..|
Worm   822 DELEDIDIGDENANP----TKNDYLLNARLDSYSVPIAPDVETSEMKRMVSQMWNQIT 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	21/91 (23%)
		COG5077	101..1119	CDD:227409	155/838 (18%)
		peptidase_C19C	239..549	CDD:239124	102/593 (17%)
		USP7_ICP0_bdg	647..886	CDD:289221	4/8 (50%)
		USP7_C2	897..1113	CDD:291217
K02C4.3	NP_001309441.1	UCH	168..744	CDD:278850	100/586 (17%)
		Peptidase_C19I	169..745	CDD:239130	100/586 (17%)
		Peptidase_C19	169..>299	CDD:271592	35/131 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900