DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and usp-5

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	NP_491765.2	Gene:	usp-5 / 172296	WormBaseID:	WBGene00020839	Length:	789	Species:	Caenorhabditis elegans

Alignment Length:	624	Identity:	114/624 - (18%)
Similarity:	194/624 - (31%)	Gaps:	198/624 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 WDSKKHT------------GYVGLKNQGATCYMNSLLQTLYFTNSLRL--------SVYRIPTEA 276
            |:..|.|            ||.||.|.|::|||||:||.|...:|.:.        ::...|  .
Worm   298 WEWSKCTEDGLLLEPIFGPGYTGLVNTGSSCYMNSVLQALVTVDSFQTRYGEQGLETLVNCP--L 360

  Fly   277 DDSSKSVGLSLQRVFHELQFGD------------RPVGTKKLTKSFGWETLDSFMQHDVQEFLRV 329
            |...........:|...:..||            :|:..|::... ......:..|.||:|::|.
Worm   361 DKLHNDFNAQFSKVVRAMLSGDYSSEMDPTNNHIKPLQFKRVAAG-NHRDFSTSKQQDVEEYIRF 424

  Fly   330 LLDKLESKMKGTILEGT------IPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIY 388
            |.:|:....:..:::.|      ....||.:.:..::..:.:....|.....|:...|.|.:|.|
Worm   425 LFEKIAENSRTEVIDPTDSFKFKAINRFEDRGTRRVRYTDQEEMLIRLPISGDLLRPIPDTENRY 489

  Fly   389 --------------ESFQDYVAPETLEGDNKYDAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYD 439
                          :...||::|.|  |:.|         .|:..:...:||..|...:.:|.|:
Worm   490 SVDMKAAIHAYFDVQKIDDYISPIT--GEPK---------GATNTISMKTFPDYLFFQVSKFAYN 543

  Fly   440 PVTDSSIKYNDRFEFYEHINLDRYLAESENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWF 504
             |..:..|.:...|..|.::|..|..           |..|.|.                    .
Worm   544 -VDGTQKKLDMELEIEEELDLSGYRG-----------HGKLEHE--------------------I 576

  Fly   505 KFDDDVVSSCRKQEAIEQNYGGMDDEISFHAKCSNA-YMLVYIRQSELDRVLGDITESEISSDLV 568
            ...|:..::.|....|..:...:..|:.....|.|| |...|.....::.....:.|....||:.
Worm   577 ALPDEEPTAPRTTPDIPASVRFVAGELMLMGFCENACYRAAYYSNGNVEIASNWLMEHMDDSDIN 641

  Fly   569 ERLDLEKRIEMARRKERGEANTYVSVHVILEENFEEQHKRRLFDLEKVHPRVFRIKQNQTVDELV 633
            :...:......|    |||.:..: |..|:|..|..            |...:.:||..||.|.|
Worm   642 DLFVIPSGTPSA----RGEVDPNL-VASIVEMGFSN------------HQAKYALKQVPTVAEAV 689

  Fly   634 DLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTIEQISTSQKPWVIWLQLAWTDVPGPL 698
            :               |        .|::.|.:...|..:...|.:.:|.|
Worm   690 E---------------W--------LFANMDSIPVESAAVGLSSDAPEPSV-------------- 717

  Fly   699 PPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDLVPDVNSKLGFEPDTELTIYDEYADK 763
                  |||.....:.|...|             .:||.::    |.:|..||
Worm   718 ------TESATQKTFKDGGEK-------------YKLIGMI----SHMGSRPD------------ 747

  Fly   764 KLVNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLP 802
                      |..::.....:|..::|..|.|....|.|
Worm   748 ----------SGHYVAHMLKEGKWVLFNDEKVALSQDPP 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	114/624 (18%)
		peptidase_C19C	239..549	CDD:239124	68/350 (19%)
		USP7_ICP0_bdg	647..886	CDD:289221	25/156 (16%)
		USP7_C2	897..1113	CDD:291217
usp-5	NP_491765.2	UBP14	19..788	CDD:227532	114/624 (18%)
		zf-UBP	185..266	CDD:280334
		Peptidase_C19B	320..786	CDD:239123	109/602 (18%)
		UBA1_scUBP14_like	597..634	CDD:270482	6/36 (17%)
		UBA_atUPL1_2_like	660..695	CDD:270512	13/70 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100