DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp7 and Usp48

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_017175494.1	Gene:	Usp48 / 170707	MGIID:	2158502	Length:	1054	Species:	Mus musculus

Alignment Length:	787	Identity:	193/787 - (24%)
Similarity:	300/787 - (38%)	Gaps:	198/787 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKSVGL------------ 285
            :.:|...:|||.|.|||||:|:.||..:....||.::|..|:...|.:|..|:
Mouse    81 ERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELRQALYLCPSTCSDYTKGDGIHGGKDYEPQTIC 145

  Fly   286 -SLQRVFHELQFGDR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLE---SKMKGTI 342
             .||.:|..||..:|    |.|   ..|:.|   ||:..|.|.|||.::.:..||   ||.|...
Mouse   146 EHLQYLFALLQNSNRRYIDPSG---FVKALG---LDTGQQQDAQEFSKLFMSLLEDTLSKQKNPD 204

  Fly   343 LEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDNKYD 407
            :...:...|.|:.:....|......|.....||:::|||:..|.:.:...:::..|.|||||:|.
Mouse   205 VRNVVQQQFCGEYAYVTVCNQCGRESKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYF 269

  Fly   408 A-GVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYLAESENTL 471
            . .....|.|::.:...|.|..|:|.||||.:|..|....|.|....|.|.::::.|:.....:.
Mouse   270 CENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNAYIGFSESLDMEPYVEHKGGSF 334

  Fly   472 ADYVLHAVLVHSG-DNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQNYG-----GMDDE 530
            . |.|.|||:|.| ..:.|||:..:.....|.|:||:|         |.||:..|     |::::
Mouse   335 V-YELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFND---------EDIEKMEGKKLQLGIEED 389

  Fly   531 ISFHAK-------------CS-NAYMLVYIRQSE-----------LDRVLGDITESEISSDLVER 570
            ::..:|             || |||||||..|::           ..:.|.|...|:.....||.
Mouse   390 LAEPSKSQTRKPKCGKGTHCSRNAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEEWCVEM 454

  Fly   571 LDLEKRI------------EMARRKERG-EANTYVSVHVI---LEENFEEQ---HKRRLFDLEKV 616
            .::.|:.            |:.:|...| |...:||:..:   |:|:...:   :...|...:|:
Mouse   455 AEMRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDNNACLCSHDKL 519

  Fly   617 HPRVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTI---EQIST 678
            ||....| ..:..:...::|...:| ...|:.:..||.         |.|.|..|.:   .|::.
Mouse   520 HPDKISI-MKRISEYAANIFYSRYG-GGPRLTVKALCK---------DCVVERCRVLRLKNQLNE 573

  Fly   679 SQKP---------------WV------IWLQLAWTDV---PGPLPPFNPKTESLLFLKYYDPRNK 719
            ..|.               ||      .|.|||...:   .|.....|.|.....|.|......|
Mouse   574 DYKAVNNLLKSTMKGSDGFWVGKSSLRSWRQLALEQLDEQDGEAEQSNGKINGSTFNKDESKEEK 638

  Fly   720 R-----LNY---IGCTQQPH--------TRRLIDLVPDVNSKLG--FEPDTELTIYDEYADK-KL 765
            :     ||:   |.|   ||        .|||:.  .:..|||.  |....|...|.|...: |:
Mouse   639 KEEEEELNFNEDILC---PHGELSISENERRLVS--QEAWSKLQQYFPKAPEFPSYRECCSQCKI 698

  Fly   766 VNLNEPIESALFIPQDHLQGHILIFERENVDAKLDLPTVGDYFLDLVYRIEIIFSDK---CNPNE 827
            :........||         |.:|...:    |..||.              :|.||   |..|.
Mouse   699 LEREGEENEAL---------HKMIANEQ----KTSLPN--------------LFQDKNRPCLSNW 736

  Fly   828 PDFT--LELSNRYNYDQLANAVAERLNTDPQKLQFFMCINNYKETAGNAV---PYTFKGTIKDLV 887
            |:.|  |.:.:.:..|:....|.:...:.|            ..:.|||.   |:  .|.:....
Mouse   737 PEDTDALYIVSHFFLDEWRKFVRKPARSAP------------VSSIGNAALLCPH--GGLMFTFP 787

  Fly   888 SYTKQSS 894
            |.||:.|
Mouse   788 SLTKEDS 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741
		COG5077	101..1119	CDD:227409	193/787 (25%)
		peptidase_C19C	239..549	CDD:239124	105/350 (30%)
		USP7_ICP0_bdg	647..886	CDD:289221	60/292 (21%)
		USP7_C2	897..1113	CDD:291217
Usp48	XP_017175494.1	Peptidase_C19L	90..419	CDD:239133	103/344 (30%)
		DUSP	484..554	CDD:368848	13/71 (18%)
		Ubl_USP48	958..1053	CDD:340493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810