DRSC/TRiP Functional Genomics Resources

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Protein Alignment Usp7 and USP18

DIOPT Version :9

Sequence 1:NP_572779.2 Gene:Usp7 / 32169 FlyBaseID:FBgn0030366 Length:1129 Species:Drosophila melanogaster
Sequence 2:NP_059110.2 Gene:USP18 / 11274 HGNCID:12616 Length:372 Species:Homo sapiens


Alignment Length:345 Identity:88/345 - (25%)
Similarity:153/345 - (44%) Gaps:46/345 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   225 DAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLY----FTNSL-RLSVYRIPTEADDSSKSVG 284
            |.|||:          |||.|.|.||.:|||:|...    ||..| |::|   |..||:..:||.
Human    49 DYPHGL----------VGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITV---PRGADEQRRSVP 100

  Fly   285 LSLQRVFHELQFGDRPVGTKKLTKSFGWE--TLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTI 347
            ..:..:..::| ..|....:.|..::..:  .:..|:|||..:....|.:.::.::....|...:
Human   101 FQMLLLLEKMQ-DSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERL 164

  Fly   348 PGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNI-----KDKKNIYESFQDYVAPETLEGDNKYD 407
            ..|:..::...:.|.:....|:|..:...:.|::     |..|.:.::...:..|..|...:|..
Human   165 QALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCF 229

  Fly   408 AGVHGLQEASKGVI-FTSFPPVLHLHLMRFQYDPVTDS-------SIKYNDRFEFYEHINLDRYL 464
            ....|.:...|.|: .|..|..|.:|||||.   :.:|       |:.:....:|.:.:.:.|..
Human   230 CENCGKKTRGKQVLKLTHLPQTLTIHLMRFS---IRNSQTRKICHSLYFPQSLDFSQILPMKRES 291

  Fly   465 AES-ENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCR-KQEAIEQNYGGM 527
            .:: |.:...|.|.||:.|.|....|||.|:|....||:||.|:|..:  |. ..|.|:..||..
Human   292 CDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNI--CLVSWEDIQCTYGNP 354

  Fly   528 DDEISFHAKCSNAYMLVYIR 547
                ::|.: ..||:|||::
Human   355 ----NYHWQ-ETAYLLVYMK 369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp7NP_572779.2 MATH_HAUSP 100..229 CDD:239741 2/3 (67%)
COG5077 101..1119 CDD:227409 88/345 (26%)
peptidase_C19C 239..549 CDD:239124 84/331 (25%)
USP7_ICP0_bdg 647..886 CDD:289221
USP7_C2 897..1113 CDD:291217
USP18NP_059110.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..45
Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 36..51 1/1 (100%)
Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510 51..112 25/74 (34%)
UCH 55..367 CDD:306860 82/325 (25%)
Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510 303..312 4/8 (50%)
Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 313..372 22/64 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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