Sequence 1: | NP_572779.2 | Gene: | Usp7 / 32169 | FlyBaseID: | FBgn0030366 | Length: | 1129 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_059110.2 | Gene: | USP18 / 11274 | HGNCID: | 12616 | Length: | 372 | Species: | Homo sapiens |
Alignment Length: | 345 | Identity: | 88/345 - (25%) |
---|---|---|---|
Similarity: | 153/345 - (44%) | Gaps: | 46/345 - (13%) |
- Green bases have known domain annotations that are detailed below.
Fly 225 DAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLY----FTNSL-RLSVYRIPTEADDSSKSVG 284
Fly 285 LSLQRVFHELQFGDRPVGTKKLTKSFGWE--TLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTI 347
Fly 348 PGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNI-----KDKKNIYESFQDYVAPETLEGDNKYD 407
Fly 408 AGVHGLQEASKGVI-FTSFPPVLHLHLMRFQYDPVTDS-------SIKYNDRFEFYEHINLDRYL 464
Fly 465 AES-ENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCR-KQEAIEQNYGGM 527
Fly 528 DDEISFHAKCSNAYMLVYIR 547 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Usp7 | NP_572779.2 | MATH_HAUSP | 100..229 | CDD:239741 | 2/3 (67%) |
COG5077 | 101..1119 | CDD:227409 | 88/345 (26%) | ||
peptidase_C19C | 239..549 | CDD:239124 | 84/331 (25%) | ||
USP7_ICP0_bdg | 647..886 | CDD:289221 | |||
USP7_C2 | 897..1113 | CDD:291217 | |||
USP18 | NP_059110.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 19..45 | ||
Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 | 36..51 | 1/1 (100%) | |||
Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510 | 51..112 | 25/74 (34%) | |||
UCH | 55..367 | CDD:306860 | 82/325 (25%) | ||
Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510 | 303..312 | 4/8 (50%) | |||
Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510 | 313..372 | 22/64 (34%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG5077 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |