Protein Alignment Usp7 and USP18

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: NP_059110.2
• Gene: USP18 / 11274
• HGNCID: 12616
• Length: 372
• Species: Homo sapiens
• Alignment Length: 345
• Identity: 88/345 - (25%)
• Similarity: 153/345 - (44%)
• Gaps: 46/345 - (13%)

  Fly   225 DAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLY----FTNSL-RLSVYRIPTEADDSSKSVG 284
            |.|||:          |||.|.|.||.:|||:|...    ||..| |::|   |..||:..:||.
Human    49 DYPHGL----------VGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITV---PRGADEQRRSVP 100

  Fly   285 LSLQRVFHELQFGDRPVGTKKLTKSFGWE--TLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTI 347
            ..:..:..::| ..|....:.|..::..:  .:..|:|||..:....|.:.::.::....|...:
Human   101 FQMLLLLEKMQ-DSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERL 164

  Fly   348 PGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNI-----KDKKNIYESFQDYVAPETLEGDNKYD 407
            ..|:..::...:.|.:....|:|..:...:.|::     |..|.:.::...:..|..|...:|..
Human   165 QALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCF 229

  Fly   408 AGVHGLQEASKGVI-FTSFPPVLHLHLMRFQYDPVTDS-------SIKYNDRFEFYEHINLDRYL 464
            ....|.:...|.|: .|..|..|.:|||||.   :.:|       |:.:....:|.:.:.:.|..
Human   230 CENCGKKTRGKQVLKLTHLPQTLTIHLMRFS---IRNSQTRKICHSLYFPQSLDFSQILPMKRES 291

  Fly   465 AES-ENTLADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCR-KQEAIEQNYGGM 527
            .:: |.:...|.|.||:.|.|....|||.|:|....||:||.|:|..:  |. ..|.|:..||..
Human   292 CDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNI--CLVSWEDIQCTYGNP 354

  Fly   528 DDEISFHAKCSNAYMLVYIR 547
                ::|.: ..||:|||::
Human   355 ----NYHWQ-ETAYLLVYMK 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	88/345 (26%)
USP18	NP_059110.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..45
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	36..51		1/1 (100%)
		Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510	51..112		25/74 (34%)
		UCH	55..367	CDD:425685	82/325 (25%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510	303..312		4/8 (50%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	313..372		22/64 (34%)