Protein Alignment Usp7 and usp24

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_002931653.2
• Gene: usp24 / 100497137
• XenbaseID: XB-GENE-6035156
• Length: 2577
• Species: Xenopus tropicalis
• Alignment Length: 1259
• Identity: 267/1259 - (21%)
• Similarity: 432/1259 - (34%)
• Gaps: 388/1259 - (30%)

  Fly     6 DQSIEAMDTQDTQEVEILTSDLQQT--QQQRNSPPQLPKFKNLIQPQLHAVGAV--TQLP--SEN 64
            |.:|:.:....:.|:..:..|...|  |...:|.|::.|      |.|..:..:  .|||  |..
 Frog  1398 DFTIDILLGSPSAEIRRVACDQLYTLSQTDTSSYPEVQK------PNLFLLTVILSAQLPLWSPT 1456

  Fly    65 GNMP--PQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPVYVR- 126
            ..|.  .|:|||  ..|.:.|.....:||              .|...:.||   .:||...:.
 Frog  1457 SIMRGINQRLLA--QCTEYFDLRCQLLDD--------------LTCSEMEQL---NVSPATMLED 1502

  Fly   127 MLPWRIMVIPNDRALGFFLQCNGENDSPTW-------------SCNAIAELR------------- 165
            .:.|.....||..|     :|........|             .|.|..|:.
 Frog  1503 EITWLDNFEPNRTA-----ECETSEADNVWLAGHLRLIKTLLSLCGAEKEMLGPSLIKQLLDDFL 1562

  Fly   166 -------LKCHKPDAQPFTRARIKHLFYSKENDYGYSNFITWQEL-KDSEKSYVHNNSITLEVHV 222
                   |..|.|........:..|...|..|    |....::.| ..:|.|..:...||.|:..
 Frog  1563 FRASRIILNSHSPAGSAAISQQDFHPKCSTMN----SRLAAYEVLVMLAESSLANLQLITKELLS 1623

  Fly   223 VADAPHGVLW---------DSKKHTGYVGLKNQGATCYMNSLLQTLYFTNSLRLSVYRIPTEADD 278
            :...|...:.         ||:.::|:|||||.|||||||::.|.||....|..::..:..:.|:
 Frog  1624 MHHQPDPAVTKEFDYLPPVDSRSNSGFVGLKNGGATCYMNAVFQQLYMQPGLPEALLSMEGDTDN 1688

  Fly   279 SSKSVGLSLQRVFHELQFGDR----PVGTKKLTKSFGWETLDSFMQHDVQEFLRVLLDKLESKMK 339
            ..:||...:|.:|..|.....    |....|:.|.:..| |....|.|..||...|:|:::..:|
 Frog  1689 PDESVFYQVQSLFGHLMESKLQYYIPENFWKIFKMWNKE-LYVREQQDAYEFFTSLIDQMDEYLK 1752

  Fly   340 GTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYESFQDYVAPETLEGDN 404
            ....|......|:|..|....||:..:...|.|.|..:.|.:...:::..|...:|..|.|||.|
 Frog  1753 KMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEILEGSN 1817

  Fly   405 KY------DAGVHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRY 463
            .|      |.     :...|.....|.|.||.:|||||.:|..:..||||:::.:|...:|::.|
 Frog  1818 AYYCEKCKDK-----RTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIKFPWMLNMEPY 1877

  Fly   464 -------------------------------LAESENTLADYVLHAVLVHSGDNHGGHYVVFINP 497
                                           :|.:||    |.|..|:||||..|.|||..||..
 Frog  1878 TVAGMARQDSSCEAGENGRHIDPGGGSPRKKVAPTEN----YELVGVIVHSGQAHAGHYYSFIKD 1938

  Fly   498 K---ADGRWFKFDDDVVSSC-RKQEAIE-QNYGG-----MDDEIS----FHAKCSNAYMLVY--- 545
            :   ..|:|:||:|.||... ...|.|| :.:||     :.|:.:    ...:..|||||.|
 Frog  1939 RRGSGKGKWYKFNDTVVEEFDLNDETIEYECFGGEYRPKVYDQSNPYPDVRRRYWNAYMLFYQRV 2003

  Fly   546 ----------------IRQSELDRVLGDITESEISSDLV-------ERLD-LEKRIEMARRK--- 583
                            :||...|..|...:..:||....       :||. |.|.:....:|
 Frog  2004 SDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPDISPQSSPRPHRPNDRLSILTKLVRKGEKKGLF 2068

  Fly   584 -ERGEANTYVSVHVILEENFEEQHKRRLFD---------LEKV------HP---RVFRIKQNQTV 629
             |:.....|.:|.   :||.:....|.:::         |..|      ||   .:.::.....:
 Frog  2069 VEKIPLRIYQTVR---DENLKFMKNRDVYNSDYFSFVLSLASVNATKLKHPLYQPMAKVSAQLAI 2130

  Fly   630 DELVDLFVRGFGVSRQRMRM----W---------NLCTAQTQKFSHFDFVAEGSRTIEQISTSQK 681
            ..|...::|    :::::|:    |         ..|.| .|....:...:||...::
 Frog  2131 QFLFHTYLR----TKRKLRVDTEEWIATIDALVSKSCEA-CQWLMEYFVCSEGKELVK------- 2183

  Fly   682 PWVIWLQLAWTDVPGPLPPFNPKT------------------ESLLFLKYYDPRNKRLNYIGCTQ 728
              :..|:.:..:|...:.....||                  |.||.|...|......|   |.|
 Frog  2184 --IFLLESSIREVRAAVATILEKTLDAALFHGDKVNGVHLLIEMLLSLLEKDVPESCKN---CAQ 2243

  Fly   729 ---------QPHTRRLIDLV-------PDVNSKLGFEPDTE------------------------ 753
                     |....|.:||:       ..:|..||  |:.:
 Frog  2244 YFYLFSNFVQKQGSRAVDLLLRYSALKHFINFLLG--PNRQNNQNRRWSSPQAREFGYLHSTIAL 2306

  Fly   754 LTIYDEYADKKLVNLNEPIESALFIPQDHLQ--GHILIFERENVDAKLDLPTVGDYFLDLVYRIE 816
            |.:|.:      |:.:..:...:|.|.....  |..|:...| |:|.:.:|....|.|::::.:.
 Frog  2307 LVLYSD------VSSHRTVAPGVFKPHPSTNTCGSPLLLHAE-VEALMFMPEGKPYLLEVMFALR 2364

  Fly   817 ------------IIFSDKCNPNEPDFTLELSNRYNYDQLANAVAERLNT------------DPQK 857
                        :::...||..   |:|.|.: :..:||..|....|..            ||.:
 Frog  2365 ELPGSLTVLIEMVVYCCFCNER---FSLTLLH-FIKNQLETAPPHELKNVFTLLYEILVIEDPLQ 2425

  Fly   858 LQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDNKKQFKCVWVS 922
            ||              .:.:||:.  ..|::....|              :.:|:.:.::||
 Frog  2426 LQ--------------RLKFTFES--DGLLALMHHS--------------NHVDSSRCYQCV--- 2457

  Fly   923 SDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRLLKISNHKIVAVCKDDIPLDTLLK 987
                  |.||....|....|...::.:...|:|....:|    |:|.|     |.  .|...:
 Frog  2458 ------KFLVTLAQKCPAAKEYFKDNSHHWSWAVQWLQK----KMSEH-----CW--APQSNI-- 2503

  Fly   988 SNESITTAQGAQKTFRIEEVPAED 1011
            |||:.|.     |||: ..|.|:|
 Frog  2504 SNETSTA-----KTFQ-RTVSAQD 2521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	243/1156 (21%)
usp24	XP_002931653.2	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	917..995	CDD:340585
		peptidase_C19C	1649..2005	CDD:239124	107/365 (29%)