DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp7 and usp18

DIOPT Version :9

Sequence 1:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster
Sequence 2:	XP_005164589.1	Gene:	usp18 / 100334535	ZFINID:	ZDB-GENE-100210-2	Length:	337	Species:	Danio rerio

Alignment Length:	364	Identity:	81/364 - (22%)
Similarity:	146/364 - (40%)	Gaps:	45/364 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 WQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMNSLLQTLYFTNS 264
            |.::. ..:.|:.::|                |.|.:.....||.|.|.:|.:|:|||:...|..
Zfish     5 WSKMA-YHRRYIRSSS----------------WSSNRGYEVRGLFNDGLSCCVNALLQSFSATTE 52

  Fly   265 LRLSVYRIPTEADDSSKS-VGLSLQRVFHELQFGDRPVGTKKLTKSFGWETLDSFMQHDVQEFLR 328
            | |.:......:|...:| :.|.|:.....::........|..........:..:.|.|..|...
Zfish    53 L-LDILNKWNPSDGIEQSNIPLQLRNTLLSVRDPSHSAPHKGFLDCLYRHAICRYTQQDADEIFH 116

  Fly   329 VLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKDKKNIYES-FQ 392
            ::|:....:|....|...|..|:..::.:.:.|.:..:......:::.:.|.|.:.:|..|| .:
Zfish   117 MILNLSLKQMPDHELAQEIRSLYTIEVETQVTCMDCTFIHRLPNSYFSLPLVIHEGENTLESCIK 181

  Fly   393 DYVAPETLEGDNKYDAG-VHGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSI--KYNDRFEF 454
            .:...:.||...|:... ....|..:......|.|.:|.:||.||:    .:..:  |.:.:..|
Zfish   182 SFFKKQKLEVSEKFFCDRCEKKQPCAYEQKLVSLPQILCVHLKRFR----NEHGLIKKLDSKVTF 242

  Fly   455 YEHINLDRYLA-ESENTL-----ADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSS 513
            .|.:.:..:.| :|||..     |||.|.||:||.|....|||..||....|..|:..:|..|:.
Zfish   243 PETLKISVFAAGQSENAASDSPQADYSLFAVIVHIGSAMFGHYTAFIRQTQDQMWYYANDSRVNQ 307

  Fly   514 CRKQEAIEQNYGGMDDEISFHAKCSNAYMLVYIRQSELD 552
            ...:: ::..|.|.:          .||:|:| |:..||
Zfish   308 ATWKD-VQDTYKGRE----------TAYLLLY-RKKSLD 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	3/28 (11%)
		COG5077	101..1119	CDD:227409	81/364 (22%)
		peptidase_C19C	239..549	CDD:239124	74/320 (23%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
usp18	XP_005164589.1	UCH	28..328	CDD:278850	72/315 (23%)
usp18	XP_005164589.1	Peptidase_C19	97..329	CDD:239072	56/247 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810