Protein Alignment Usp7 and usp47

DIOPT Version :10

• Sequence 1: NP_572779.2
• Gene: Usp7 / 32169
• FlyBaseID: FBgn0030366
• Length: 1129
• Species: Drosophila melanogaster
• Sequence 2: XP_021333046.1
• Gene: usp47 / 100101645
• ZFINID: ZDB-GENE-070719-7
• Length: 1374
• Species: Danio rerio
• Alignment Length: 1224
• Identity: 274/1224 - (22%)
• Similarity: 458/1224 - (37%)
• Gaps: 375/1224 - (30%)

  Fly    59 QLPSENGNMPPQQLLADSSSTSFGDGEAMGIDDESKEDQFRSETTFSFTVENVVQLKSQRLSPPV 123
            ||..::|..|  |:.:|.|:|:    ::.|:|| |.:|:|                    :.|
Zfish   125 QLTDKDGEQP--QIASDESATA----DSGGLDD-SSQDRF--------------------IGP-- 160

  Fly   124 YVRMLPWRIMVIPNDRALGFFLQCNGENDSPTWSCNAIAELRLKCHKPDAQPFTRARIKHLFYSK 188
                       :|.|..:|    |:.:..||:
Zfish   161 -----------LPRDGTVG----CSSDYSSPS--------------------------------- 177

  Fly   189 ENDYGYSNFITWQELKDSEKSYVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQGATCYMN 253
               |.||:.:                                   :|..||||||.||..|||:|
Zfish   178 ---YSYSSIL-----------------------------------NKSETGYVGLVNQAMTCYLN 204

  Fly   254 SLLQTLYFTNSLRLSVYRIPTEADDSSK----SVGLSLQRVFHELQFG-DRPVGTKKLTKSFGWE 313
            ||||||:.|...|.::|.  .|.:||.:    |:...|||:|..||.. .|.:.|..:|:||||:
Zfish   205 SLLQTLFMTPEFRNALYN--WEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWD 267

  Fly   314 TLDSFMQHDVQEFLRVLLDKLESKMKGTILEGTIPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQ 378
            :.:::.||||||..||:.|.||.|.|.|.....|..|::||:..|::|....|.|.|.:|:.||.
Zfish   268 SSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINQLYQGKLKDYVRCLECGYESWRIDTYLDIP 332

  Fly   379 LNIKD------KKNIYESFQDYVAPETLEGDNKY---------DAGVHGLQEASKGVIFTSFPPV 428
            |.|:.      ..::.|:.|.::.||||:|.|:|         |        |.||:.|..||.:
Zfish   333 LVIRPFGASQAFGSVEEALQAFIQPETLDGPNQYFCERCKKKCD--------ARKGLRFLHFPYL 389

  Fly   429 LHLHLMRFQYDPVTDSSIKYNDRFEFYEHINLDRYL-----------------AESENTL----- 471
            |.|.|.||.:|..|...||.|||..|.|.:::..::                 ||:|.:.
Zfish   390 LTLQLKRFDFDYTTMHRIKLNDRMTFPEELDMSPFIDVEDEKSPQTESCTDSGAENEGSCHSDQM 454

  Fly   472 -------------------------------ADYVLHAVLVHSGDNHGGHYVVFINPKADGRWFK 505
                                           ..:.|.:|:||||...||||...|...:|.:|:.
Zfish   455 SNDFSTDDGVDEGICLDNASSAERVLKPKSSLTFELFSVMVHSGSAAGGHYYACIKSFSDSQWYS 519

  Fly   506 FDDDVVSSCRKQEAIEQNYGGMDDEISFH----AKCSNAYMLVYIRQSELDRVLGDITESEISSD 566
            |:|..||.. .|:.|.:.|||......::    |..:|||||:| |..:..|....:...:....
Zfish   520 FNDQHVSKI-TQDDIRKTYGGSSGSRGYYSSAFASSTNAYMLMY-RLKDPSRNAKFLEVEDFPEH 582

  Fly   567 LVERLDLEKRIEMARRKERG-EANT-------YVSVHVILEENFEEQHK-----------RRLFD 612
            :...:..||..|...:::|. |.||       ...|.:::.||..|.||           .:|.|
Zfish   583 IKRLVQREKESEEQEKRQREIERNTCKIKLFCMHPVKMMMMENKLEVHKDKTLNEATEMAYKLMD 647

  Fly   613 LEKVHP----RVFRIKQNQTVDELVDLFVRGFGVSRQRMRMWNLCTAQTQKFSHFDFVAEGSRTI 673
            ||.|.|    |:.:      .||..:...|.: ...:.|.| .|.....:....||.:.| .|..
Zfish   648 LEGVVPLDCCRLVK------YDEFHEYLERSY-EGEEDMPM-GLLLGGVKSSYMFDLLLE-IRRP 703

  Fly   674 EQISTSQKPWVIWLQLAWTDVPGPLPPFNPKTESLLFLKYYDPRNKRLNYIGCTQQPHTRRLIDL 738
            ||.....||..:.:::...|:         |:||:.     .|.:.|. |:..|       :.:.
Zfish   704 EQAFQPYKPGEVMVKVHVVDL---------KSESIA-----APVSVRA-YLNQT-------ITEF 746

  Fly   739 VPDVNSKLGFEPDTELTIYDE-YADKKLVNL-NEPIE-------SALFIPQDHLQGHILIFEREN 794
            ...:....|...:|...:.:. |.|.:|:.: |:.::       :.:|:.......|...| .::
Zfish   747 KQLIAQATGLCAETMRVVLERCYNDLRLLYVPNKTLKAEGFFRSNKVFVESSDSTDHQAAF-TDS 810

  Fly   795 VDAKLDLPTVGD---YFLDLVYRIEIIFSDKCN------PNEPDFTLELSNRYNYDQLANAVAER 850
            |..|| |...|:   .|:.|..:....|:::.:      .:|..|....:.|.:.:.:.....|:
Zfish   811 VLWKL-LDRHGNTIRLFVSLPEQSPGSFANRTSCPKASADSEDSFDGAKAGRKSVEAILEESTEK 874

  Fly   851 L-NTDPQKLQFFMCINNYKETAGNAVPYTFKGTIKDLVSYTKQSSTKRIFYQRLSLSIHELDNKK 914
            | |...|:.|      ..::|:..:               ..|.|::...::.:.....|.|...
Zfish   875 LKNLSLQQQQ------QQQQTSSTS---------------DSQKSSEHSDFEHIESPAQEPDASS 918

  Fly   915 Q----FKCVWVSSDLKDEKELVLYPNKNDTVKGLLEEAAKKISFAENSRRKLRL---LKISNHKI 972
            |    ..|...:||..::     :|::.           :..|...|.|....:   :..|:|..
Zfish   919 QPSQTENCTRAASDTDNQ-----FPSEE-----------RSDSDVNNDRSTSSVDSDILSSSHSS 967

  Fly   973 VAVCKDD---IPLDTLLKSNESITTA------QGAQKTF-RIEEVPAEDMQLAEN-------EFL 1020
            ..:|..|   :||...|.|: |||::      :|.::|: ..||....|.:..||       ::|
Zfish   968 DTLCNADSGPLPLANGLDSH-SITSSRRSKAHEGKKETWDTAEEDSGTDSEYDENGKSKADTQYL 1031

  Fly  1021 IPVAHFSKELYNSFGIPFLTKARQGEPYGALKQRIQRRLNVQDKEWENYKFCVISMGHNADVNDN 1085
                :|..|       |:..:...|:...:|...:.:|:.            :.:...|.:....
Zfish  1032 ----YFKAE-------PYSQEDGAGDGQKSLLVHVDKRIT------------LAAFKQNLEPFVG 1073

  Fly  1086 TP-VDLEVYRSWTSGQ----------LPFFGLDHINKSRKRSSLNFSEKAIKIY 1128
            .| ...:|:|.:.:.|          |.||..|:....|...:|...|..:|:|
Zfish  1074 VPSTQFKVFRVYANNQEFESVRLNETLSFFSDDNKITIRLGRALKKGEYRVKVY 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp7	NP_572779.2	Peptidase_C19	101..1119	CDD:470612	256/1171 (22%)
usp47	XP_021333046.1	peptidase_C19C	190..567	CDD:239124	128/388 (33%)
		MSCRAMM_ClfA	<902..>1028	CDD:468110	28/142 (20%)
		USP47_C	1123..1362	CDD:466158	2/5 (40%)