DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and DUF1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_014554.1	Gene:	DUF1 / 854066	SGDID:	S000005447	Length:	1116	Species:	Saccharomyces cerevisiae

Alignment Length:	334	Identity:	62/334 - (18%)
Similarity:	105/334 - (31%)	Gaps:	131/334 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 TSLVRASLANSNADMSANGAIASH---LQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAV 180
            :.|:..::.||:..........||   :.||...|..       ..|. .::|..|..:::||..
Yeast    83 SDLIHVNMKNSDPSAGDTFISVSHDFSIVLISVNAQL-------TTWD-KKIIGDHDDYIKCIVP 139

  Fly   181 --------------------------------EPGNEWFATGAGDRVIKIWDLASGKLKLSL--- 210
                                            |..|..|.||..||.||:|.|:||..|::.
Yeast   140 IHYEMSNDYELEEQEGGPDNVHDGINNGIVVDEQNNFLFVTGGLDRKIKLWCLSSGPEKMATLLH 204

  Fly   211 ---------TGHVSTVRGVAV-------STKHPYLFSCGE-DRQVKCWDLEYNK-VIRHYHGHLS 257
                     ||.:.::..:..       .|..|:.|..|: :..:..:..:|.| |||..:.|.:
Yeast   205 TFDNAQSNDTGSIYSMSPIIPKYSFDDNQTSRPFDFVAGDCNGDLIFYSCKYRKEVIRIQNAHRT 269

  Fly   258 AVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTV 322
               ::.:..|:|       |||                                ::|:.|.|..:
Yeast   270 ---NIKVVRTLD-------DST--------------------------------RLISTSSDGVI 292

  Fly   323 RLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWR------CPEGKFVQNISGHT 381
            .:|||..        .|.::..::.|           |..|..|.      |.:|..:..:....
Yeast   293 NVWDLNC--------RHDQTTGALQL-----------PKKIGSWSWDSSIWCVQGTSLDKLYFGD 338

  Fly   382 SIVNCMAAN 390
            |..|.|.||
Yeast   339 SQGNVMRAN 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	54/289 (19%)
		WD40	164..458	CDD:238121	53/286 (19%)
		WD40 repeat	177..212	CDD:293791	16/78 (21%)
		WD40 repeat	218..254	CDD:293791	9/44 (20%)
		WD40 repeat	259..295	CDD:293791	5/35 (14%)
		WD40 repeat	302..337	CDD:293791	6/34 (18%)
		WD40 repeat	343..378	CDD:293791	6/40 (15%)
		WD40 repeat	386..426	CDD:293791	3/5 (60%)
		WD40 repeat	433..457	CDD:293791
DUF1	NP_014554.1	WD40	10..296	CDD:421866	47/262 (18%)
		WD40 repeat	165..207	CDD:293791	14/41 (34%)
		WD40 repeat	218..264	CDD:293791	9/45 (20%)
		WD40 repeat	271..309	CDD:293791	12/84 (14%)
		WD40 repeat	337..383	CDD:293791	5/11 (45%)
		WD40 repeat	392..418	CDD:293791
		Ubl_WDR48	1018..1098	CDD:340561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910