DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and DOA1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_012709.1	Gene:	DOA1 / 853667	SGDID:	S000001696	Length:	715	Species:	Saccharomyces cerevisiae

Alignment Length:	345	Identity:	85/345 - (24%)
Similarity:	135/345 - (39%)	Gaps:	82/345 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 WKLSRVISGHLGWVR-CIAVEPGNEWFATGAGDRVIKIWD---------------------LASG 204
            ::||..:.||...|| .:||:...  .|:.:.|..:::|.                     ..|.
Yeast     3 YQLSATLKGHDQDVRDVVAVDDSK--VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSE 65

  Fly   205 KLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTID 269
            |..|...|..:.:.||      |...:.|||..       |..:     ||...|.||:..   |
Yeast    66 KELLLFGGKDTMINGV------PLFATSGEDPL-------YTLI-----GHQGNVCSLSFQ---D 109

  Fly   270 VLATSGR-DSTARIWDMRTKANVHTLTGHTNTV--ASVVAQATNPQIITGSHDSTVRLWDLAAGK 331
            .:..||. |.||::|  :..:.|:.|..|..:|  |.||:.:.| :.:|.|.|.|::||.  ..|
Yeast   110 GVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSEN-KFLTASADKTIKLWQ--NDK 169

  Fly   332 SVCTLTN-HKKSVRSIVL----HPSLYMFASASPDN-IKQWRCPEGKFVQNISGHTSIVNCMAAN 390
            .:.|.:. |...||.:.:    |     |.|.|.|. ||......|..::...||.|.|.|:...
Yeast   170 VIKTFSGIHNDVVRHLAVVDDGH-----FISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLL 229

  Fly   391 SEGVLVSGGDNGTMFFWDWRTGYNFQRFQAP-VQPGSMDSEAGIFAMCFDQSGSRLITAEADKTI 454
            ..|.:||.|::.|:..|....|...|....| :...|:|        |  .|...:|...:|..:
Yeast   230 PNGDIVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVD--------C--MSNGDIIVGSSDNLV 284

  Fly   455 KVYKE-------DDEASEES 467
            :::.:       :||.:|.|
Yeast   285 RIFSQEKSRWASEDEINELS 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	81/327 (25%)
		WD40	164..458	CDD:238121	81/325 (25%)
		WD40 repeat	177..212	CDD:293791	8/55 (15%)
		WD40 repeat	218..254	CDD:293791	7/35 (20%)
		WD40 repeat	259..295	CDD:293791	11/36 (31%)
		WD40 repeat	302..337	CDD:293791	12/34 (35%)
		WD40 repeat	343..378	CDD:293791	10/39 (26%)
		WD40 repeat	386..426	CDD:293791	10/40 (25%)
		WD40 repeat	433..457	CDD:293791	4/23 (17%)
DOA1	NP_012709.1	WD40	5..288	CDD:238121	81/325 (25%)
		WD40 repeat	58..97	CDD:293791	11/56 (20%)
		WD40 repeat	102..134	CDD:293791	11/36 (31%)
		WD40 repeat	142..175	CDD:293791	12/35 (34%)
		WD40 repeat	182..217	CDD:293791	10/39 (26%)
		WD40 repeat	223..260	CDD:293791	10/36 (28%)
		WD40 repeat	267..287	CDD:293791	5/29 (17%)
		PFU	333..443	CDD:401130
		PUL	468..712	CDD:400564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910