DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and TAF5

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_009757.1	Gene:	TAF5 / 852497	SGDID:	S000000402	Length:	798	Species:	Saccharomyces cerevisiae

Alignment Length:	441	Identity:	112/441 - (25%)
Similarity:	170/441 - (38%)	Gaps:	77/441 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KLRRSIKAKDGYG-----LVLDKVAKIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYN 101
            |...:.|.||..|     .:.||:|| .|.:|.|..:..|:|                    |.:
Yeast   368 KAMNNEKFKDNTGDDDKDKIKDKIAK-DEEKKESELKVDGEK--------------------KDS 411

  Fly   102 AGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSR 166
            ..:.||....||...|...|   .|.......|.:.....:|||      ::|....:.....::
Yeast   412 NLSSPARDILPLPPKTALDL---KLEIQKVKESRDAIKLDNLQL------ALPSVCMYTFQNTNK 467

  Fly   167 VISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLK-----------------LSLTGHV 214
            .:|       |:.........|.|..|..||||.|....|.                 .:|.||.
Yeast   468 DMS-------CLDFSDDCRIAAAGFQDSYIKIWSLDGSSLNNPNIALNNNDKDEDPTCKTLVGHS 525

  Fly   215 STVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDST 279
            .||...:.|..:.||.|..||:.|:.|.::.:..:..|.||...|:.::..|.....||:..|.|
Yeast   526 GTVYSTSFSPDNKYLLSGSEDKTVRLWSMDTHTALVSYKGHNHPVWDVSFSPLGHYFATASHDQT 590

  Fly   280 ARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVR 344
            ||:|.......:....||.|.|..|........:.|||.|.|.|:||::.|.||.....|...|.
Yeast   591 ARLWSCDHIYPLRIFAGHLNDVDCVSFHPNGCYVFTGSSDKTCRMWDVSTGDSVRLFLGHTAPVI 655

  Fly   345 SIVLHPSLYMFASASPDN-IKQWRCPEGKFVQNISGH-TSIVNCMAANSEG-VLVSGGDNGTMFF 406
            ||.:.|.....::.|.|. |..|....||.::.:.|| .:.:..::.:.|| ||:|||.:.|:..
Yeast   656 SIAVCPDGRWLSTGSEDGIINVWDIGTGKRLKQMRGHGKNAIYSLSYSKEGNVLISGGADHTVRV 720

  Fly   407 WDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVY 457
            ||.:        :|..:|.:...|..|..:     |.  :||..::.||.|
Yeast   721 WDLK--------KATTEPSAEPDEPFIGYL-----GD--VTASINQDIKEY 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	85/317 (27%)
		WD40	164..458	CDD:238121	85/314 (27%)
		WD40 repeat	177..212	CDD:293791	11/51 (22%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	9/35 (26%)
		WD40 repeat	302..337	CDD:293791	12/34 (35%)
		WD40 repeat	343..378	CDD:293791	10/35 (29%)
		WD40 repeat	386..426	CDD:293791	12/40 (30%)
		WD40 repeat	433..457	CDD:293791	6/23 (26%)
TAF5	NP_009757.1	LisH	55..88	CDD:128913
		TFIID_NTD2	149..275	CDD:398277
		WD40	458..722	CDD:238121	73/270 (27%)
		WD40 repeat	470..523	CDD:293791	12/59 (20%)
		WD40 repeat	529..565	CDD:293791	9/35 (26%)
		WD40 repeat	570..606	CDD:293791	9/35 (26%)
		WD40 repeat	613..648	CDD:293791	12/34 (35%)
		WD40 repeat	654..690	CDD:293791	10/35 (29%)
		WD40 repeat	697..732	CDD:293791	12/42 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910