DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and TRM82

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_010449.1	Gene:	TRM82 / 851743	SGDID:	S000002572	Length:	444	Species:	Saccharomyces cerevisiae

Alignment Length:	336	Identity:	62/336 - (18%)
Similarity:	113/336 - (33%)	Gaps:	99/336 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 NSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAG 192
            |.|..:.:|..     ..|.:.|..:|.|...||     .|..::..:|..:.|  :...|....
Yeast    71 NENKKLKSNKG-----DSIKRTAAKVPSPGLGAP-----PIYSYIRNLRLTSDE--SRLIACADS 123

  Fly   193 DRVIKIWDL---ASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHG 254
            |:.:.::|:   :...|||         |.....:|.|...|..||        :...:|....|
Yeast   124 DKSLLVFDVDKTSKNVLKL---------RKRFCFSKRPNAISIAED--------DTTVIIADKFG 171

  Fly   255 HLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASV--VAQATNPQ-IITG 316
            .   |||:.::...:                 .|.....:.||.:.:..|  :..:...| |||.
Yeast   172 D---VYSIDINSIPE-----------------EKFTQEPILGHVSMLTDVHLIKDSDGHQFIITS 216

  Fly   317 SHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHT 381
            ..|..:::             :|         :|..::        :.:|          :.||.
Yeast   217 DRDEHIKI-------------SH---------YPQCFI--------VDKW----------LFGHK 241

  Fly   382 SIVNCMAANSEGVLVSGGDNGTMFFWDWRTGYNFQRF--QAPVQPGSMDSEAGIFAMCFDQSGSR 444
            ..|:.:....:.:|:|.|.:..:|.|||:||.|...|  .:.::|...|..  :....|....:.
Yeast   242 HFVSSICCGKDYLLLSAGGDDKIFAWDWKTGKNLSTFDYNSLIKPYLNDQH--LAPPRFQNENND 304

  Fly   445 LITAEADKTIK 455
            :|.....|.||
Yeast   305 IIEFAVSKIIK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	54/303 (18%)
		WD40	164..458	CDD:238121	53/300 (18%)
		WD40 repeat	177..212	CDD:293791	7/37 (19%)
		WD40 repeat	218..254	CDD:293791	7/35 (20%)
		WD40 repeat	259..295	CDD:293791	4/35 (11%)
		WD40 repeat	302..337	CDD:293791	6/37 (16%)
		WD40 repeat	343..378	CDD:293791	2/34 (6%)
		WD40 repeat	386..426	CDD:293791	12/41 (29%)
		WD40 repeat	433..457	CDD:293791	5/23 (22%)
TRM82	NP_010449.1	WD40 repeat	7..46	CDD:293791
		WD40 repeat	106..148	CDD:293791	9/52 (17%)
		WD40	<112..278	CDD:421866	43/244 (18%)
		WD40 repeat	152..192	CDD:293791	10/67 (15%)
		WD40 repeat	199..238	CDD:293791	9/78 (12%)
		WD40 repeat	244..279	CDD:293791	11/34 (32%)
		WD40 repeat	310..352	CDD:293791	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910