DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango4 and THOC3

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_115737.1 Gene:THOC3 / 84321 HGNCID:19072 Length:351 Species:Homo sapiens


Alignment Length:321 Identity:78/321 - (24%)
Similarity:124/321 - (38%) Gaps:49/321 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   182 PGN--EWFATGAGDR--VIKIWDLASGKLKL-SLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCW 241
            ||:  .|.:..:|..  |:.:.:|..|..|. ....|.:.|..||.|.....|.|...|:....:
Human    18 PGSMAPWCSVSSGPSRYVLGMQELFRGHSKTREFLAHSAKVHSVAWSCDGRRLASGSFDKTASVF 82

  Fly   242 DLEYNKVIR--HYHGHLSAVYSLALHPT-IDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVAS 303
            .||.:::::  :|.||..:|..|..||: .|:..|:..|.|.||||:||...:.|:    ||...
Human    83 LLEKDRLVKENNYRGHGDSVDQLCWHPSNPDLFVTASGDKTIRIWDVRTTKCIATV----NTKGE 143

  Fly   304 VVAQATNPQ---IITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPD---N 362
            .:....:|.   |..|:.|..|...|....:|... ...|..|..|..:....||...:.:   |
Human   144 NINICWSPDGQTIAVGNKDDVVTFIDAKTHRSKAE-EQFKFEVNEISWNNDNNMFFLTNGNGCIN 207

  Fly   363 IKQWRCPEGKFVQNISGHTSIVNCMAANSEG-VLVSGGDNGTMFFWD------WRTGYNFQRFQA 420
            |..:  ||.|.||:|:.|.|...|:..:..| ...:|..:..:..||      .|.   |.|...
Human   208 ILSY--PELKPVQSINAHPSNCICIKFDPMGKYFATGSADALVSLWDVDELVCVRC---FSRLDW 267

  Fly   421 PVQPGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVYKEDD-------EASEESHPINWRP 474
            ||:           .:.|...|..|.:|..|..|.:.:.:.       :....:..:.|.|
Human   268 PVR-----------TLSFSHDGKMLASASEDHFIDIAEVETGDKLWEVQCESPTFTVAWHP 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 76/296 (26%)
WD40 164..458 CDD:238121 76/296 (26%)
WD40 repeat 177..212 CDD:293791 8/34 (24%)
WD40 repeat 218..254 CDD:293791 9/37 (24%)
WD40 repeat 259..295 CDD:293791 15/36 (42%)
WD40 repeat 302..337 CDD:293791 7/37 (19%)
WD40 repeat 343..378 CDD:293791 11/37 (30%)
WD40 repeat 386..426 CDD:293791 10/46 (22%)
WD40 repeat 433..457 CDD:293791 6/23 (26%)
THOC3NP_115737.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 1/1 (100%)
WD40 49..290 CDD:238121 67/261 (26%)
WD 1 53..94 10/40 (25%)
WD40 repeat 59..97 CDD:293791 9/37 (24%)
WD 2 97..137 16/39 (41%)
WD40 repeat 102..139 CDD:293791 15/40 (38%)
WD 3 139..178 9/38 (24%)
WD40 repeat 145..180 CDD:293791 7/35 (20%)
WD 4 180..221 12/42 (29%)
WD40 repeat 185..221 CDD:293791 11/37 (30%)
WD 5 222..261 7/38 (18%)
WD40 repeat 227..263 CDD:293791 6/38 (16%)
WD 6 264..303 9/49 (18%)
WD40 repeat 269..295 CDD:293791 7/36 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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