DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and SPA4

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001321533.1	Gene:	SPA4 / 841743	AraportID:	AT1G53090	Length:	794	Species:	Arabidopsis thaliana

Alignment Length:	461	Identity:	92/461 - (19%)
Similarity:	175/461 - (37%)	Gaps:	85/461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 KIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRAS- 125
            :|.:..:.:.|:...|......:....|...  .:|::.:...|..:|...:...|....::|:
plant   349 RIRQGAETTAAEEENDDNSIDEESKLDDTLE--STLLESSRLMRNLKKLESVYFATRYRQIKAAT 411

  Fly   126 -----LANSNADMSANGAIASHLQLI-PKKAP---------------------SIPKPKWHAPWK 163
                 ||...:.:|.||..:....:. |.|.|                     |..|.:..|..|
plant   412 AAEKPLARYYSALSCNGRSSEKSSMSQPSKDPINDSRQGGWIDPFLEGLCKYLSFSKLRVKADLK 476

  Fly   164 LSRVI-SGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLAS----------------GKLKLSLT 211
            ...:: |.:|  |..|..:...|:|||...::.|||::..|                .:.|||..
plant   477 QGDLLNSSNL--VCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSGI 539

  Fly   212 GHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSL---ALHPTIDVLAT 273
            ...|.::....|:..        :..|:.||:..|:::.....|...|:|:   :..||:  ||:
plant   540 CWNSYIKSQVASSNF--------EGVVQVWDVARNQLVTEMKEHEKRVWSIDYSSADPTL--LAS 594

  Fly   274 SGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGK-SVCTLT 337
            ...|.:.::|.:....::.|:....|.........|...:..||.|..|..:||...| .:||:.
plant   595 GSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSETGRSLAFGSADHKVYYYDLRNPKLPLCTMI 659

  Fly   338 NHKKSVRSIVLHPSLYMFASASPDNIKQW----------RCPEGKFVQNISGHTSIVNCMAAN-S 391
            .|.|:|..:....|..:.:|::.:.:|.|          ..|...|:    |||::.|.:..: |
plant   660 GHHKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSISGINETPLHSFM----GHTNVKNFVGLSVS 720

  Fly   392 EGVLVSGGDNGTMFFWDWR-----TGYNFQRFQAPVQPGSMDSEAG-IFAMCFDQSGSRLITAEA 450
            :|.:.:|.:...:|.:...     ..|.|:... ||....:|..:. |.::|:....|.|:.|.:
plant   721 DGYIATGSETNEVFVYHKAFPMPVLSYKFKTID-PVSELEVDDASQFISSVCWRGQSSTLVAANS 784

  Fly   451 DKTIKV 456
            ...||:
plant   785 TGNIKI 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	72/334 (22%)
		WD40	164..458	CDD:238121	71/331 (21%)
		WD40 repeat	177..212	CDD:293791	12/50 (24%)
		WD40 repeat	218..254	CDD:293791	5/35 (14%)
		WD40 repeat	259..295	CDD:293791	9/38 (24%)
		WD40 repeat	302..337	CDD:293791	10/35 (29%)
		WD40 repeat	343..378	CDD:293791	7/44 (16%)
		WD40 repeat	386..426	CDD:293791	8/45 (18%)
		WD40 repeat	433..457	CDD:293791	7/24 (29%)
SPA4	NP_001321533.1	PLN00181	1..794	CDD:177776	92/461 (20%)
		WD40 repeat	487..529	CDD:293791	10/41 (24%)
		WD40 repeat	537..574	CDD:293791	7/44 (16%)
		WD40 repeat	579..615	CDD:293791	8/37 (22%)
		WD40 repeat	622..659	CDD:293791	10/36 (28%)
		WD40 repeat	665..706	CDD:293791	6/40 (15%)
		WD40 repeat	713..759	CDD:293791	9/46 (20%)
		WD40 repeat	767..790	CDD:293791	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910