DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tango4 and RUP2

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_568435.2 Gene:RUP2 / 832438 AraportID:AT5G23730 Length:368 Species:Arabidopsis thaliana


Alignment Length:448 Identity:89/448 - (19%)
Similarity:150/448 - (33%) Gaps:122/448 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 ERLEKLRRSIKAKDGYGLVLDKV--AKIGEARKASGA--QTPGDKTLAITDGSATDAASGAGSLV 98
            ::.|:.::..:|:..:.|.|..|  :....|....||  ..|.|..:|....|......|..||:
plant     9 QQQEQAQQQEEARYEWDLSLSTVVSSSSSSASDVIGAIEFDPTDNIVATAGISRKIRFYGLPSLL 73

  Fly    99 KYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWK 163
            :.||           |:||..|.|..:.|            ..:....|.|..|:   :|     
plant    74 RNNA-----------VSGTGVSFVDQATA------------CEYYICTPAKLSSL---RW----- 107

  Fly   164 LSRVISGHLGWVRCIAVEPGNEWFATGAG--DRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKH 226
                             .||:.....|:|  |.|:..:||                      .|.
plant   108 -----------------RPGSGGRVIGSGDYDGVVMEYDL----------------------EKR 133

  Fly   227 PYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMR----T 287
            ..:|...|....:.|.::|.:     ||..|.|.           |:...|.|.::||.|    .
plant   134 TPVFERDEHGGRRVWSVDYTR-----HGGASTVG-----------ASGSDDGTMQVWDPRCPPEE 182

  Fly   288 KANVHTLTGHTNTVASVVA--QATNPQIITGSHDSTVRLWDLAAGKSV---CTLTNHKKSVRSIV 347
            ...|....|...:....|.  .:..|.:..|..|....::|:.  |.|   .||..|.|:|..:.
plant   183 SVGVVRPAGICRSAVCCVEFDPSGGPAVAVGCADRKGYVYDIR--KLVDPALTLQGHTKTVSYVR 245

  Fly   348 LHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAAN--SEGVLVS-GGDNGTMFFWD- 408
            ......:..:.:...:|.|...:|:.::...||.:..|.:..:  ..|.|.. |.:|..:|.:| 
plant   246 FLDGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSVWRNGALFGCGSENNRVFVYDR 310

  Fly   409 ------WRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSG---SRLITAEADKTIKVY 457
                  |..|:.      ||...|...:..:.::|:.|||   ..|:...:|..::||
plant   311 RWGKPVWVDGFE------PVGMNSGSDKRFVSSVCWRQSGVDQCTLVAGGSDGVLQVY 362

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 62/321 (19%)
WD40 164..458 CDD:238121 62/318 (19%)
WD40 repeat 177..212 CDD:293791 8/36 (22%)
WD40 repeat 218..254 CDD:293791 5/35 (14%)
WD40 repeat 259..295 CDD:293791 8/39 (21%)
WD40 repeat 302..337 CDD:293791 8/39 (21%)
WD40 repeat 343..378 CDD:293791 4/34 (12%)
WD40 repeat 386..426 CDD:293791 10/49 (20%)
WD40 repeat 433..457 CDD:293791 6/26 (23%)
RUP2NP_568435.2 WD40 41..362 CDD:295369 81/414 (20%)
WD40 repeat 46..82 CDD:293791 11/46 (24%)
WD40 repeat 96..140 CDD:293791 14/90 (16%)
WD40 repeat 148..190 CDD:293791 13/57 (23%)
WD40 repeat 197..235 CDD:293791 8/39 (21%)
WD40 repeat 241..276 CDD:293791 4/34 (12%)
WD40 repeat 283..308 CDD:293791 6/24 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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