DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and RUP2

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_568435.2	Gene:	RUP2 / 832438	AraportID:	AT5G23730	Length:	368	Species:	Arabidopsis thaliana

Alignment Length:	448	Identity:	89/448 - (19%)
Similarity:	150/448 - (33%)	Gaps:	122/448 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ERLEKLRRSIKAKDGYGLVLDKV--AKIGEARKASGA--QTPGDKTLAITDGSATDAASGAGSLV 98
            ::.|:.::..:|:..:.|.|..|  :....|....||  ..|.|..:|....|......|..||:
plant     9 QQQEQAQQQEEARYEWDLSLSTVVSSSSSSASDVIGAIEFDPTDNIVATAGISRKIRFYGLPSLL 73

  Fly    99 KYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWK 163
            :.||           |:||..|.|..:.|            ..:....|.|..|:   :|
plant    74 RNNA-----------VSGTGVSFVDQATA------------CEYYICTPAKLSSL---RW----- 107

  Fly   164 LSRVISGHLGWVRCIAVEPGNEWFATGAG--DRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKH 226
                             .||:.....|:|  |.|:..:||                      .|.
plant   108 -----------------RPGSGGRVIGSGDYDGVVMEYDL----------------------EKR 133

  Fly   227 PYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMR----T 287
            ..:|...|....:.|.::|.:     ||..|.|.           |:...|.|.::||.|    .
plant   134 TPVFERDEHGGRRVWSVDYTR-----HGGASTVG-----------ASGSDDGTMQVWDPRCPPEE 182

  Fly   288 KANVHTLTGHTNTVASVVA--QATNPQIITGSHDSTVRLWDLAAGKSV---CTLTNHKKSVRSIV 347
            ...|....|...:....|.  .:..|.:..|..|....::|:.  |.|   .||..|.|:|..:.
plant   183 SVGVVRPAGICRSAVCCVEFDPSGGPAVAVGCADRKGYVYDIR--KLVDPALTLQGHTKTVSYVR 245

  Fly   348 LHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAAN--SEGVLVS-GGDNGTMFFWD- 408
            ......:..:.:...:|.|...:|:.::...||.:..|.:..:  ..|.|.. |.:|..:|.:|
plant   246 FLDGGTVVTAGTDGCLKLWSVEDGRVIRTYEGHVNNRNFVGLSVWRNGALFGCGSENNRVFVYDR 310

  Fly   409 ------WRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSG---SRLITAEADKTIKVY 457
                  |..|:.      ||...|...:..:.::|:.|||   ..|:...:|..::||
plant   311 RWGKPVWVDGFE------PVGMNSGSDKRFVSSVCWRQSGVDQCTLVAGGSDGVLQVY 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	62/321 (19%)
		WD40	164..458	CDD:238121	62/318 (19%)
		WD40 repeat	177..212	CDD:293791	8/36 (22%)
		WD40 repeat	218..254	CDD:293791	5/35 (14%)
		WD40 repeat	259..295	CDD:293791	8/39 (21%)
		WD40 repeat	302..337	CDD:293791	8/39 (21%)
		WD40 repeat	343..378	CDD:293791	4/34 (12%)
		WD40 repeat	386..426	CDD:293791	10/49 (20%)
		WD40 repeat	433..457	CDD:293791	6/26 (23%)
RUP2	NP_568435.2	WD40	41..362	CDD:295369	81/414 (20%)
		WD40 repeat	46..82	CDD:293791	11/46 (24%)
		WD40 repeat	96..140	CDD:293791	14/90 (16%)
		WD40 repeat	148..190	CDD:293791	13/57 (23%)
		WD40 repeat	197..235	CDD:293791	8/39 (21%)
		WD40 repeat	241..276	CDD:293791	4/34 (12%)
		WD40 repeat	283..308	CDD:293791	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910