DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AT3G16650

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_566557.1	Gene:	AT3G16650 / 820917	AraportID:	AT3G16650	Length:	479	Species:	Arabidopsis thaliana

Alignment Length:	487	Identity:	228/487 - (46%)
Similarity:	320/487 - (65%)	Gaps:	28/487 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DVQKHSVHTLIFRSLKRTHDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLV--LDKVAKIGEAR 67
            :|:..|:..|..:|::|..::|....|..|:.|...:::|...|.:..:|.|  ..|..:|.:..
plant     9 EVETQSLKKLSLKSVRRAREIFSPVHGQFPQPDPESKRIRLCHKIQVAFGGVEPASKPTRIADHN 73

  Fly    68 KASGA-----QTPGDKTLAITDGSATDAASGAGSLV---KYNAGARPAEKTAPLVTGTHTSLVRA 124
            ....|     ..||.|.......|||:.|...|..:   ..|....|         |..|:::.|
plant    74 SEKTAPLKALALPGPKGSKELRKSATEKALVVGPTLPPRDLNNTGNP---------GKSTAILPA 129

  Fly   125 SLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFAT 189
            ..:.|..::|.    |:.::.:|.:   .|:|:||||||..||:.|||||||.:|.:|.||||.|
plant   130 PGSFSERNLST----AALMERMPSR---WPRPEWHAPWKNYRVLQGHLGWVRSVAFDPSNEWFCT 187

  Fly   190 GAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHG 254
            |:.||.|||||:|:|.|||:||||:..|||:|||.:|.|:||.|:|:||||||||.|||||.|||
plant   188 GSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVSNRHTYMFSAGDDKQVKCWDLEQNKVIRSYHG 252

  Fly   255 HLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHD 319
            ||..||.||||||:||:.|.||||..|:||:|||..:..|. |.:.|.||:|:.|:||:||||||
plant   253 HLHGVYCLALHPTLDVVLTGGRDSVCRVWDIRTKMQIFVLP-HDSDVFSVLARPTDPQVITGSHD 316

  Fly   320 STVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQN-ISGHTSI 383
            ||::.|||..|||:.|:|||||:||::.|||....|.|||.||||::..|:|:|..| :|....|
plant   317 STIKFWDLRYGKSMATITNHKKTVRAMALHPKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDI 381

  Fly   384 VNCMAANSEGVLVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITA 448
            :|.:|.|.:||:|:|||.|.::||||::|:||||.:..|||||::|||||:|.|:||:||||:|.
plant   382 INAVAVNEDGVMVTGGDKGGLWFWDWKSGHNFQRAETIVQPGSLESEAGIYAACYDQTGSRLVTC 446

  Fly   449 EADKTIKVYKEDDEASEESHPINWRPDLLKRR 480
            |.|||||::|||::|:.|:||:|::|....||
plant   447 EGDKTIKMWKEDEDATPETHPLNFKPPKEIRR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	179/297 (60%)
		WD40	164..458	CDD:238121	176/294 (60%)
		WD40 repeat	177..212	CDD:293791	21/34 (62%)
		WD40 repeat	218..254	CDD:293791	25/35 (71%)
		WD40 repeat	259..295	CDD:293791	21/35 (60%)
		WD40 repeat	302..337	CDD:293791	21/34 (62%)
		WD40 repeat	343..378	CDD:293791	17/35 (49%)
		WD40 repeat	386..426	CDD:293791	21/39 (54%)
		WD40 repeat	433..457	CDD:293791	16/23 (70%)
AT3G16650	NP_566557.1	WD40	162..456	CDD:238121	176/294 (60%)
		WD40 repeat	175..210	CDD:293791	21/34 (62%)
		WD40 repeat	216..252	CDD:293791	25/35 (71%)
		WD40 repeat	257..293	CDD:293791	21/35 (60%)
		WD40 repeat	299..334	CDD:293791	21/34 (62%)
		WD40 repeat	340..376	CDD:293791	17/35 (49%)
		WD40 repeat	382..421	CDD:293791	19/38 (50%)
		WD40 repeat	428..455	CDD:293791	19/26 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2004
Inparanoid	1	1.050	472	1.000	Inparanoid score	I352
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1157847at2759
OrthoFinder	1	1.000	-	-		FOG0004264
OrthoInspector	1	1.000	-	-		otm3339
orthoMCL	1	0.900	-	-		OOG6_101928
Panther	1	1.100	-	-	O	PTHR19923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3002
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840